Inflammatory arthritis in systemic sclerosis is associated with elevated C-reactive protein and requires musculoskeletal ultrasound for reliable detection.
CRP
arthritis
imaging
musculoskeletal ultrasound
systemic sclerosis
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2022
2022
Historique:
received:
01
05
2022
accepted:
21
12
2022
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
7
2
2023
Statut:
epublish
Résumé
About 25% of patients with systemic sclerosis (SSc) have elevated C-reactive protein (CRP) levels. Specific causes of CRP elevation are unknown so far. We aimed to investigate whether inflammatory arthritis is associated with CRP elevation. Furthermore, we evaluated the sensitivity and specificity of clinical examination compared to musculoskeletal ultrasound (MSUS) for detection of arthritis. Sixty-five patients with SSc (51 females) were enrolled and allocated into a CRP-positive (CRP+, Patient with a disease duration <3 years had higher CRP levels ( Arthritis is more frequent in CRP + compared to CRP- SSc patients. Compared to MSUS sensitivity of clinical examination is low for the detection of arthritis; this is likely due to skin fibrosis and soft tissue edema. Therefore, regular monitoring via MSUS should be considered as routine assessment in SSc patients.
Identifiants
pubmed: 36743676
doi: 10.3389/fmed.2022.933809
pmc: PMC9889538
doi:
Types de publication
Journal Article
Langues
eng
Pagination
933809Informations de copyright
Copyright © 2023 Feldmann, Jandova, Heilmeier, Kollert, Voll and Finzel.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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