Impaired Early Insulin Response to Glucose Load Predicts Episodic Memory Decline: A 10-Year Population-Based Cohort Follow-Up of 45-74-Year-Old Men and Women.
Cognitive decline
early insulin response
episodic memory
insulin resistance
insulin secretion
oral glucose tolerance test
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2023
2023
Historique:
pubmed:
7
2
2023
medline:
15
3
2023
entrez:
6
2
2023
Statut:
ppublish
Résumé
Diabetes increases the risk for cognitive decline, but the mechanisms behind this association remain unknown. Impaired early insulin secretion in elderly men and insulin resistance, both of which are pathophysiological features of type 2 diabetes, have previously been linked to Alzheimer's disease. To examine if the early insulin response to oral glucose load predicts cognitive performance after 10 years in men and women aged 45-74 years. This study was based on a subpopulation of the Health 2000 Survey, a Finnish nationwide, population-based health examination study, and its follow-up, the Health 2011 Study. In total, 961 45-74-year-old individuals (mean age at baseline 55.6 years, 55.8% women) were examined. An oral glucose tolerance test was performed in 2001-2002, and early insulin response was defined as the ratio of the 30-min increment in insulin concentration to that of glucose concentration. Cognitive function was evaluated at baseline and follow-up with categorical verbal fluency, word-list learning, and word-list delayed recall. Statistical analyses were performed using multivariable linear models adjusted for age, sex, education, APOE&z.epsi;4 genotype, vascular risk factors including diabetes, and depressive symptoms. A lower early insulin response to glucose load predicted lower performance (β: 0.21, p = 0.03) and greater decline (β: 0.19, p = 0.03) in the word-list delayed recall test. Baseline early insulin response did not predict verbal fluency or word-list learning (all p-values≥0.13). Our results suggest that decreased early insulin secretion predicts episodic memory decline in middle-aged to elderly men and women.
Sections du résumé
BACKGROUND
Diabetes increases the risk for cognitive decline, but the mechanisms behind this association remain unknown. Impaired early insulin secretion in elderly men and insulin resistance, both of which are pathophysiological features of type 2 diabetes, have previously been linked to Alzheimer's disease.
OBJECTIVE
To examine if the early insulin response to oral glucose load predicts cognitive performance after 10 years in men and women aged 45-74 years.
METHODS
This study was based on a subpopulation of the Health 2000 Survey, a Finnish nationwide, population-based health examination study, and its follow-up, the Health 2011 Study. In total, 961 45-74-year-old individuals (mean age at baseline 55.6 years, 55.8% women) were examined. An oral glucose tolerance test was performed in 2001-2002, and early insulin response was defined as the ratio of the 30-min increment in insulin concentration to that of glucose concentration. Cognitive function was evaluated at baseline and follow-up with categorical verbal fluency, word-list learning, and word-list delayed recall. Statistical analyses were performed using multivariable linear models adjusted for age, sex, education, APOE&z.epsi;4 genotype, vascular risk factors including diabetes, and depressive symptoms.
RESULTS
A lower early insulin response to glucose load predicted lower performance (β: 0.21, p = 0.03) and greater decline (β: 0.19, p = 0.03) in the word-list delayed recall test. Baseline early insulin response did not predict verbal fluency or word-list learning (all p-values≥0.13).
CONCLUSION
Our results suggest that decreased early insulin secretion predicts episodic memory decline in middle-aged to elderly men and women.
Identifiants
pubmed: 36744339
pii: JAD220894
doi: 10.3233/JAD-220894
pmc: PMC10041429
doi:
Substances chimiques
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
349-359Références
Lancet Neurol. 2022 Nov;21(11):962-964
pubmed: 36270305
Diabetes. 2006 May;55(5):1430-5
pubmed: 16644701
JAMA Neurol. 2013 Sep 1;70(9):1167-72
pubmed: 23897112
Neurology. 2021 Sep 14;97(11):e1110-e1122
pubmed: 34380754
Diabetes Res Clin Pract. 2017 Feb;124:41-47
pubmed: 28088029
Alzheimers Dement. 2016 Aug;12(8):882-9
pubmed: 26812281
Diabetologia. 1985 Jul;28(7):412-9
pubmed: 3899825
Neurology. 2008 Sep 30;71(14):1065-71
pubmed: 18401020
Neurology. 2010 Aug 31;75(9):764-70
pubmed: 20739649
Int J Obes (Lond). 2020 Jun;44(6):1254-1263
pubmed: 31965072
Intern Med J. 2012 May;42(5):484-91
pubmed: 22372522
Diabetologia. 2009 Aug;52(8):1504-10
pubmed: 19455303
Neurology. 1989 Sep;39(9):1159-65
pubmed: 2771064
Lancet Neurol. 2020 Sep;19(9):758-766
pubmed: 32730766
J Alzheimers Dis. 2019;72(1):215-228
pubmed: 31561373
Diabetes Care. 2004 Jun;27(6):1433-8
pubmed: 15161800
N Engl J Med. 2013 Aug 8;369(6):540-8
pubmed: 23924004
Neurology. 2013 Nov 12;81(20):1746-52
pubmed: 24153444
Stroke. 2008 Feb;39(2):397-402
pubmed: 18096844
BMJ. 1997 Oct 25;315(7115):1045-9
pubmed: 9366728
Neurology. 2010 Nov 30;75(22):1982-7
pubmed: 21115952
Lancet Diabetes Endocrinol. 2020 Jun;8(6):535-545
pubmed: 32445740
Brain. 2023 Jan 5;146(1):337-348
pubmed: 36374264
Diabetes Care. 2001 Jan;24(1):89-94
pubmed: 11194248
Neurology. 2004 Oct 12;63(7):1187-92
pubmed: 15477536
Diabetes Care. 1999 Sep;22(9):1462-70
pubmed: 10480510
Neurology. 2018 Mar 27;90(13):e1150-e1157
pubmed: 29476033
Environ Res. 2013 Jan;120:43-54
pubmed: 23089109
J Lipid Res. 2004 Dec;45(12):2303-9
pubmed: 15342679
J Clin Endocrinol Metab. 2009 Nov;94(11):4575-83
pubmed: 19820020
BMJ. 2010 Jul 26;341:c3666
pubmed: 20660506
Diabetes Care. 2006 Dec;29(12):2688-93
pubmed: 17130206
Hypertension. 1993 Nov;22(5):771-9
pubmed: 8225537
Lancet. 2009 Jun 27;373(9682):2215-21
pubmed: 19515410
Lancet Neurol. 2010 Jan;9(1):119-28
pubmed: 20083042
Alzheimers Dement. 2019 Jan;15(1):25-33
pubmed: 30114414
Diabetes. 2012 Feb;61(2):447-53
pubmed: 22275086
Eur J Pharmacol. 2013 Nov 5;719(1-3):170-179
pubmed: 24070815
Diabetes Care. 2017 Jun;40(6):751-758
pubmed: 28381479
Front Psychol. 2014 Jul 22;5:772
pubmed: 25101034
N Engl J Med. 1993 Dec 30;329(27):1988-92
pubmed: 8247074
Lancet. 2012 Jun 16;379(9833):2279-90
pubmed: 22683128
Lancet Neurol. 2016 Apr;15(5):455-532
pubmed: 26987701
Diabet Med. 1998 Jul;15(7):539-53
pubmed: 9686693
J Alzheimers Dis. 2017;60(3):1035-1043
pubmed: 28984587
Diabetologia. 2011 Jul;54(7):1645-52
pubmed: 21360189
Diabetes Care. 2021 Oct;44(10):2435-2437
pubmed: 34762595
Lancet Diabetes Endocrinol. 2014 Mar;2(3):246-55
pubmed: 24622755
Diabetes Care. 2008 Feb;31(2):347-52
pubmed: 18000184
Lancet Diabetes Endocrinol. 2015 Jan;3(1):75-89
pubmed: 25163604
Neurology. 2008 Sep 30;71(14):1057-64
pubmed: 18367704