A preliminary choroid plexus volumetric study in individuals with psychosis.
cerebrospinal fluid
manual segmentation
neuroinflammation
perivascular space
schizophrenia
ventricle
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 04 2023
15 04 2023
Historique:
revised:
13
12
2022
received:
05
05
2022
accepted:
21
01
2023
pubmed:
7
2
2023
medline:
23
3
2023
entrez:
6
2
2023
Statut:
ppublish
Résumé
The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.
Identifiants
pubmed: 36744628
doi: 10.1002/hbm.26224
pmc: PMC10028672
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2465-2478Subventions
Organisme : NIMH NIH HHS
ID : U01 MH109977
Pays : United States
Organisme : NIMH NIH HHS
ID : K24 MH110807
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH102377
Pays : United States
Informations de copyright
© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
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