Genome-wide analysis of genes involved in efflux function and regulation within
Tn-Seq
TraDIS
acrB
functional genomics
marA
ramA
soxS
tolC
Journal
Microbiology (Reading, England)
ISSN: 1465-2080
Titre abrégé: Microbiology (Reading)
Pays: England
ID NLM: 9430468
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
pubmed:
7
2
2023
medline:
9
2
2023
entrez:
6
2
2023
Statut:
ppublish
Résumé
The incidence of multidrug-resistant bacteria is increasing globally, with efflux pumps being a fundamental platform limiting drug access and synergizing with other mechanisms of resistance. Increased expression of efflux pumps is a key feature of most cells that are resistant to multiple antibiotics. Whilst expression of efflux genes can confer benefits, production of complex efflux systems is energetically costly and the expression of efflux is highly regulated, with cells balancing benefits against costs. This study used TraDIS-
Identifiants
pubmed: 36745554
doi: 10.1099/mic.0.001296
pmc: PMC10197877
doi:
Substances chimiques
Bacterial Proteins
0
Anti-Bacterial Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/F/000PR10349
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R012504/1
Pays : United Kingdom
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