Association of polysialic acid serum levels with schizophrenia spectrum and bipolar disorder-related structural brain changes and hospitalization.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
06 02 2023
06 02 2023
Historique:
received:
24
08
2022
accepted:
01
02
2023
entrez:
6
2
2023
pubmed:
7
2
2023
medline:
9
2
2023
Statut:
epublish
Résumé
Expression of polysialic acid (polySia) in the adult brain is enriched in areas of continuous neurogenesis and plasticity such as the hippocampus. Genome-wide association studies identified variants of glycosylation enzyme-encoding genes, required for the generation of polySia, to be associated with the development of schizophrenia and bipolar disorder. Here, we report that serum levels of polySia are increased in patients with schizophrenia spectrum disorder compared to patients with major depressive disorders or demographically matched healthy controls. Furthermore, elevated polySia serum levels are associated with structural hippocampal gray matter decline in schizophrenia spectrum and bipolar disorder. In patients with schizophrenia spectrum disorder, polySia serum levels correlate with the number, duration of disease-related hospitalizations, early retirement and medical leave as estimators of detrimental long-term disease trajectories. Our data show that polySia serum levels are linked to structural hippocampal brain changes in schizophrenia spectrum and bipolar disorders, and suggest a contribution of polySia to the pathophysiology of these diseases.
Identifiants
pubmed: 36747002
doi: 10.1038/s41598-023-29242-3
pii: 10.1038/s41598-023-29242-3
pmc: PMC9902615
doi:
Substances chimiques
polysialic acid
0
Sialic Acids
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2085Informations de copyright
© 2023. The Author(s).
Références
Hum Brain Mapp. 2015 Mar;36(3):1065-76
pubmed: 25366810
Adv Carbohydr Chem Biochem. 1982;40:131-234
pubmed: 6762816
Glia. 2021 Dec;69(12):2845-2862
pubmed: 34406679
Glia. 2020 May;68(5):989-998
pubmed: 31774586
J Neurochem. 2014 Jan;128(2):267-79
pubmed: 24117969
ACS Appl Mater Interfaces. 2016 Dec 28;8(51):35045-35058
pubmed: 27750011
World Psychiatry. 2021 Oct;20(3):417-436
pubmed: 34505386
Am J Psychiatry. 2013 Oct;170(10):1114-33
pubmed: 23982148
Mol Psychiatry. 2021 Dec;26(12):7661-7670
pubmed: 34363013
Nano Lett. 2019 Feb 13;19(2):829-838
pubmed: 30605619
Biochim Biophys Acta. 2016 Aug;1860(8):1739-52
pubmed: 27105834
J Psychiatr Res. 2012 Feb;46(2):189-97
pubmed: 22099865
Front Cell Neurosci. 2013 May 07;7:61
pubmed: 23675315
Nat Med. 2019 Feb;25(2):277-283
pubmed: 30664784
Mol Psychiatry. 2005 May;10(5):486-99
pubmed: 15534619
J Neurochem. 2006 Jul;98(1):78-88
pubmed: 16805798
Hum Brain Mapp. 2022 Jan;43(1):341-351
pubmed: 32198905
Biol Psychiatry. 2006 Apr 1;59(7):652-9
pubmed: 16229822
Front Immunol. 2022 Feb 11;12:823637
pubmed: 35222358
PLoS One. 2016 May 31;11(5):e0155631
pubmed: 27244229
Glia. 2021 Jul;69(7):1619-1636
pubmed: 33340149
PLoS One. 2014 Jul 22;9(7):e102692
pubmed: 25051163
Physiol Rev. 2014 Apr;94(2):461-518
pubmed: 24692354
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Int J Mol Sci. 2017 May 24;18(6):
pubmed: 28538701
Cell Mol Life Sci. 2021 Feb;78(4):1637-1653
pubmed: 32725371
Acta Neuropathol. 2016 Sep;132(3):317-38
pubmed: 27522506
Proc Natl Acad Sci U S A. 2010 Jun 1;107(22):10250-5
pubmed: 20479255
J Biol Chem. 2004 Jul 30;279(31):32603-13
pubmed: 15140899
Curr Psychiatry Rev. 2006 Nov;2(4):431-438
pubmed: 17487285
Nat Neurosci. 2019 Mar;22(3):374-385
pubmed: 30718903
Neurosci Lett. 2012 Nov 14;530(1):97-102
pubmed: 23022470
Neuroimage. 2018 May 15;172:450-460
pubmed: 29410079
Neurology. 2019 Mar 5;92(10):e1007-e1015
pubmed: 30737333
PLoS One. 2012;7(5):e38172
pubmed: 22693595
Neuroimage. 2003 Jul;19(3):1233-9
pubmed: 12880848
Brain Struct Funct. 2015 Jan;220(1):71-83
pubmed: 24057454
Mol Psychiatry. 2020 Dec;25(12):3129-3139
pubmed: 32377000
Nature. 2016 Feb 11;530(7589):177-83
pubmed: 26814963
Psychopharmacology (Berl). 2004 Jun;174(1):151-62
pubmed: 15205886
JAMA Psychiatry. 2014 Nov;71(11):1222-30
pubmed: 25188810
Biol Psychiatry. 2020 Nov 1;88(9):678-686
pubmed: 32646651
Transl Psychiatry. 2015 Oct 13;5:e658
pubmed: 26460482
Neurology. 2017 Feb 28;88(9):826-831
pubmed: 28148632
Int J Neuropsychopharmacol. 2008 Aug;11(5):591-5
pubmed: 18593508
Glia. 2015 Jul;63(7):1240-55
pubmed: 25752299
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2785-9
pubmed: 7708724
Eur Arch Psychiatry Clin Neurosci. 2019 Dec;269(8):949-962
pubmed: 30267149
Eur Neuropsychopharmacol. 2009 Feb;19(2):125-37
pubmed: 19042107
Trends Pharmacol Sci. 2021 Dec;42(12):998-1008
pubmed: 34607695
Schizophr Res. 2020 Mar;217:114-123
pubmed: 31130400
Nat Rev Neurosci. 2008 Jan;9(1):26-35
pubmed: 18059411
JAMA Psychiatry. 2021 Jan 01;78(1):47-63
pubmed: 32857118
Schizophr Bull. 2016 Jul;42 Suppl 1:S90-4
pubmed: 27460622
Glia. 2016 Aug;64(8):1314-30
pubmed: 27159043
Bipolar Disord. 2008 Dec;10(8):916-27
pubmed: 19594507
J Biol Chem. 2007 Oct 19;282(42):30346-56
pubmed: 17699524
Sci Rep. 2022 Apr 6;12(1):5818
pubmed: 35388026
J Biol Chem. 2011 Jun 17;286(24):21535-45
pubmed: 21464126