Choroidal vascularity index in hereditary optic neuropathies.
Journal
Eye (London, England)
ISSN: 1476-5454
Titre abrégé: Eye (Lond)
Pays: England
ID NLM: 8703986
Informations de publication
Date de publication:
09 2023
09 2023
Historique:
received:
05
05
2022
accepted:
10
01
2023
revised:
04
12
2022
pmc-release:
01
09
2024
medline:
8
9
2023
pubmed:
8
2
2023
entrez:
7
2
2023
Statut:
ppublish
Résumé
To assess the choroidal vascularity index (CVI) in patients affected by Leber hereditary optic neuropathy (LHON) compared to patients affected by dominant optic atrophy (DOA) and healthy subjects. In this retrospective study, we considered three cohorts: LHON eyes (48), DOA eyes (48) and healthy subjects' eyes (48). All patients underwent a complete ophthalmologic examination, including best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) acquisition. OCT parameters as subfoveal choroidal thickness (Sub-F ChT), mean choroidal thickness (ChT), total choroidal area (TCA), luminal choroidal area (LCA) were calculated. CVI was obtained as the ratio of LCA and TCA. Subfoveal ChT in LHON patients did not show statistically significant differences compared to controls, while in DOA a reduction in choroidal thickness was observed (p = 0.344 and p = 0.045, respectively). Mean ChT was reduced in both LHON and DOA subjects, although this difference reached statistical significance only in DOA (p = 0.365 and p = 0.044, respectively). TCA showed no significant differences among the 3 cohorts (p = 0.832). No changes were detected in LCA among the cohorts (p = 0.389), as well as in the stromal choroidal area (SCA, p = 0.279). The CVI showed no differences among groups (p = 0.898): LHON group was characterized by a similar CVI in comparison to controls (p = 0.911) and DOA group (p = 0.818); the DOA group was characterized by a similar CVI in comparison to controls (p = 1.0). CVI is preserved in DOA and LHON patients, suggesting that even in the chronic phase of the neuropathy the choroidal structure is not irreversibly compromised.
Identifiants
pubmed: 36747110
doi: 10.1038/s41433-023-02383-5
pii: 10.1038/s41433-023-02383-5
pmc: PMC10482917
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2679-2684Informations de copyright
© 2023. The Author(s), under exclusive licence to The Royal College of Ophthalmologists.
Références
Theodorou-Kanakari A, Karampitianis S, Karageorgou V, Kampourelli E, Kapasakis E, Theodossiadis P, et al. Current and emerging treatment modalities for Leber’s hereditary optic neuropathy: A review of the literature. Adv Ther. 2018;35:1510–8.
doi: 10.1007/s12325-018-0776-z
pubmed: 30173326
pmcid: 6182630
Yu-Wai-Man P, Griffiths PG, Brown DT, Howell N, Turnbull DM, Chinnery PF. The epidemiology of Leber hereditary optic neuropathy in the North East of England. Am J Hum Genet. 2003;72:333–9. Erratum in: Am J Hum Genet. 2016;98:1271.
doi: 10.1086/346066
pubmed: 12518276
Wallace DC, Singh G, Lott MT, Hodge JA, Schurr TG, Lezza AM, et al. Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy. Science. 1988;242:1427–30.
doi: 10.1126/science.3201231
pubmed: 3201231
Yu-Wai-Man P, Griffiths PG, Burke A, Sellar PW, Clarke MP, Gnanaraj L, et al. The prevalence and natural history of dominant optic atrophy due to OPA1 mutations. Ophthalmology. 2010;117:1538–46.
doi: 10.1016/j.ophtha.2009.12.038
pubmed: 20417570
Moster SJ, Moster ML, Bryan MS, Sergott RC. Retinal ganglion cell and inner plexiform layer loss correlate with visual acuity loss in LHON: A longitudinal, segmentation OCT analysis. Investig Ophthalmol Vis Sci. 2016. https://doi.org/10.1167/iovs.15-17328 .
Asanad S, Tian JJ, Frousiakis S, Jiang JP, Kogachi K, Felix CM, et al. Optical coherence tomography of the retinal ganglion cell complex in Leber’s hereditary optic neuropathy and dominant optic atrophy. Curr Eye Res. 2019;44:638–44.
doi: 10.1080/02713683.2019.1567792
pubmed: 30649972
Barboni P, Carbonelli M, Savini G, Ramos Cdo V, Carta A, Berezovsky A, et al. Natural history of Leber’s hereditary optic neuropathy: Longitudinal analysis of the retinal nerve fiber layer by optical coherence tomography. Ophthalmology. 2010;117:623–7.
doi: 10.1016/j.ophtha.2009.07.026
pubmed: 20031228
Borrelli E, Triolo G, Cascavilla ML, La Morgia C, Rizzo G, Savini G, et al. Changes in Choroidal Thickness follow the RNFL Changes in Leber’s Hereditary Optic Neuropathy. Sci Rep. 2016;6:37332.
doi: 10.1038/srep37332
pubmed: 27853297
pmcid: 5112509
Ikuno Y, Tano Y. Retinal and choroidal biometry in highly myopic eyes with spectral-domain optical coherence tomography. Investig Ophthalmol Vis Sci. 2009. https://doi.org/10.1167/iovs.08-3325 .
Koizumi H, Yamagishi T, Yamazaki T, Kawasaki R, Kinoshita S. Subfoveal choroidal thickness in typical age-related macular degeneration and polypoidal choroidal vasculopathy. Graefe’s Arch Clin Exp Ophthalmol. 2011. https://doi.org/10.1007/s00417-011-1620-1 .
Agrawal R, Gupta P, Tan KA, Cheung CM, Wong TY, Cheng CY. Choroidal vascularity index as a measure of vascular status of the choroid: Measurements in healthy eyes from a population-based study. Sci Rep. 2016;6:21090.
doi: 10.1038/srep21090
pubmed: 26868048
pmcid: 4751574
Branchini LA, Adhi M, Regatieri CV, Nandakumar N, Liu JJ, Laver N, et al. Analysis of choroidal morphologic features and vasculature in healthy eyes using spectral-domain optical coherence tomography. Ophthalmology. 2013;120:1901–8.
doi: 10.1016/j.ophtha.2013.01.066
pubmed: 23664466
Weill Y, Brosh K, Levi Vineberg T, Arieli Y, Caspi A, Potter MJ, et al. Enhanced depth imaging in swept-source optical coherence tomography: Improving visibility of choroid and sclera, a masked study. Eur J Ophthalmol. 2020;30:1295–1300.
doi: 10.1177/1120672119863560
pubmed: 31347398
Park Y, Cho KJ. Choroidal vascular index in patients with open angle glaucoma and preperimetric glaucoma. PLoS One. 2019. https://doi.org/10.1371/journal.pone.0213336 .
Velaga SB, Nittala MG, Vupparaboina KK, Jana S, Chhablani J, Haines J, et al. Choroidal vascularity index and choroidal thickness in eyes with reticular pseudodrusen. Retina. 2020;40:612–7.
doi: 10.1097/IAE.0000000000002667
pubmed: 31634322
Agrawal R, Chhablani J, Tan KA, Shah S, Sarvaiya C, Banker A. Choroidal vascularity index in central serous chorioretinopathy. Retina. 2016;36:1646–51.
doi: 10.1097/IAE.0000000000001040
pubmed: 27124882
Shi F, Liu B, Zhou Y, Yu C, Jiang T. Hippocampal volume and asymmetry in mild cognitive impairment and Alzheimer’s disease: Meta-analyses of MRI studies. Hippocampus. 2009;19:1055–64.
doi: 10.1002/hipo.20573
pubmed: 19309039
Sonoda S, Sakamoto T, Yamashita T, Shirasawa M, Uchino E, Terasaki H, et al. Choroidal structure in normal eyes and after photodynamic therapy determined by binarization of optical coherence tomographic images. Invest Ophthalmol Vis Sci. 2014;55:3893–9.
doi: 10.1167/iovs.14-14447
pubmed: 24894395
Berenberg TL, Metelitsina TI, Madow B, Dai Y, Ying GS, Dupont JC, et al. The association between drusen extent and foveolar choroidal blood flow in age-related macular degeneration. Retina. 2012;32:25–31.
doi: 10.1097/IAE.0b013e3182150483
pubmed: 21878837
pmcid: 3244536
Agrawal R, Ding J, Sen P, Rousselot A, Chan A, Nivison-Smith L, et al. Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index. Prog Retin Eye Res. 2020;77:100829.
doi: 10.1016/j.preteyeres.2020.100829
pubmed: 31927136
Zhao M, Alonso-Caneiro D, Lee R, Cheong AMY, Yu WY, Wong HY, et al. Comparison of choroidal thickness measurements using semiautomated and manual segmentation methods. Optom Vis Sci. 2020;97:121–7.
doi: 10.1097/OPX.0000000000001473
pubmed: 32011585
Agrawal R, Seen S, Vaishnavi S, Vupparaboina KK, Goud A, Rasheed MA, et al. Choroidal vascularity index using swept-source and spectral-domain optical coherence tomography: A comparative study. Ophthalmic Surg Lasers Imaging Retin. 2019;50:e26–e32.
doi: 10.3928/23258160-20190129-15
Giannaccare G, Pellegrini M, Sebastiani S, Bernabei F, Moscardelli F, Iovino C, et al. Choroidal vascularity index quantification in geographic atrophy using binarization of enhanced-depth imaging optical coherence tomographic scans. Retina. 2020;40:960–5.
doi: 10.1097/IAE.0000000000002459
pubmed: 30676528
Sacconi R, Battista M, Borrelli E, Senni C, Tombolini B, Grosso D, et al. Choroidal vascularity index is associated with geographic atrophy progression. Retina. 2022;42:381–7.
doi: 10.1097/IAE.0000000000003305
pubmed: 34561405
Kim M, Ha MJ, Choi SY, Park YH. Choroidal vascularity index in type-2 diabetes analyzed by swept-source optical coherence tomography. Sci Rep. 2018. https://doi.org/10.1038/s41598-017-18511-7 .
Bansal R, Gupta A, Gupta V, Dogra MR, Sharma A, Bambery P. Tubercular serpiginous-like choroiditis presenting as multifocal serpiginoid choroiditis. Ophthalmology. 2012;119:2334–42.
doi: 10.1016/j.ophtha.2012.05.034
pubmed: 22892153
Park JW, Suh MH, Agrawal R, Khandelwal N. Peripapillary choroidal vascularity index in glaucoma—A comparison between spectral-domain OCT and OCT angiography. Investig. Ophthalmol Vis Sci. 2018. https://doi.org/10.1167/iovs.18-24315 .
Pellegrini M, Giannaccare G, Bernabei F, Moscardelli F, Schiavi C, Campos EC. Choroidal vascular changes in arteritic and nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 2019;205:43–49.
doi: 10.1016/j.ajo.2019.03.028
pubmed: 30954470
Darvizeh F, Asanad S, Falavarjani KG, Wu J, Tian JJ, Bandello F, et al. Choroidal thickness and the retinal ganglion cell complex in chronic Leber’s hereditary optic neuropathy: A prospective study using swept-source optical coherence tomography. Eye (Lond) 2020;34:1624–30.
doi: 10.1038/s41433-019-0695-5
pubmed: 31804625
Carelli V, Ross-Cisneros FN, Sadun AA. Mitochondrial dysfunction as a cause of optic neuropathies. Prog Retin Eye Res. 2004. https://doi.org/10.1016/j.preteyeres.2003.10.003 .
Chevrollier A, Guillet V, Loiseau D, Gueguen N, de Crescenzo MA, Verny C, et al. Hereditary optic neuropathies share a common mitochondrial coupling defect. Ann Neurol. 2008;63:794–8.
doi: 10.1002/ana.21385
pubmed: 18496845
Sadun A, Carelli V, La Morgia C, Karanjia R. Leber’s Hereditary Optic Neuropathy (LHON) mtDNA mutations cause cell death by overproduction of reactive oxygen species. Acta Ophthalmol. 2015. https://doi.org/10.1111/j.1755-3768.2015.0131 .
Borrelli E, Balasubramanian S, Triolo G, Barboni P, Sadda SR, Sadun AA. Topographic macular microvascular changes and correlation with visual loss in chronic leber hereditary optic neuropathy. Am J Ophthalmol. 2018;192:217–28.
doi: 10.1016/j.ajo.2018.05.029
pubmed: 29885298