Loss of the endocytic tumor suppressor HD-PTP phenocopies LKB1 and promotes RAS-driven oncogenesis.

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
27 Jan 2023
Historique:
pubmed: 8 2 2023
medline: 8 2 2023
entrez: 7 2 2023
Statut: epublish

Résumé

Oncogenic RAS mutations drive aggressive cancers that are difficult to treat in the clinic, and while direct inhibition of the most common KRAS variant in lung adenocarcinoma (G12C) is undergoing clinical evaluation, a wide spectrum of oncogenic RAS variants together make up a large percentage of untargetable lung and GI cancers. Here we report that loss-of-function alterations (mutations and deep deletions) in the gene that encodes HD-PTP (

Identifiants

DOI: 10.1101/2023.01.26.525772 PMID: 36747658 PMC: PMC9900931
pubmed: 36747658
doi: 10.1101/2023.01.26.525772
pmc: PMC9900931
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NCI NIH HHS
ID : P30 CA138292
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA217691
Pays : United States

Auteurs

Chang-Soo Seong (CS)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.

Chunzi Huang (C)

Cancer Animal Models Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Austin C Boese (AC)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.
Cancer Biology Graduate Program, Laney Graduate School, Emory University, Atlanta, GA, USA.

Yuning Hou (Y)

Cancer Animal Models Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Junghui Koo (J)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.

Janna K Mouw (JK)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.

Manali Rupji (M)

Biostatistics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Greg Joseph (G)

Data and Technology Applications Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA.

H Richard Johnston (HR)

Emory Integrated Computational Core, Emory University, Atlanta, GA.

Henry Claussen (H)

Emory Integrated Computational Core, Emory University, Atlanta, GA.

Jeffrey M Switchenko (JM)

Biostatistics Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Madhusmita Behera (M)

Data and Technology Applications Shared Resource, Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Michelle Churchman (M)

M2Gen, Tampa, FL, USA.

Jill M Kolesar (JM)

Markey Cancer Center, University of Kentucky, Lexington, KY, USA.

Susanne M Arnold (SM)

Markey Cancer Center, University of Kentucky, Lexington, KY, USA.

Katie Kerrigan (K)

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Wallace Akerley (W)

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Howard Colman (H)

Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.

Margaret A Johns (MA)

Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Cletus Arciero (C)

Department of Surgery, Emory University School of Medicine, Atlanta, GA USA.

Wei Zhou (W)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.
Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Adam I Marcus (AI)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.
Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Suresh S Ramalingam (SS)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.
Winship Cancer Institute of Emory University, Atlanta, GA, USA.

Haian Fu (H)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.
Department of Pharmacology and Chemical Biology, Emory University School of Medicine, Atlanta, GA, USA.

Melissa Gilbert-Ross (M)

Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, GA USA.
Winship Cancer Institute of Emory University, Atlanta, GA, USA.
ORCID: 0000-0002-1960-8302

Classifications MeSH