Development of a novel mathematical model that explains SARS-CoV-2 infection dynamics in Caco-2 cells.

COVID-19 Caco-2 Mathematical model SARS-CoV-2

Journal

PeerJ
ISSN: 2167-8359
Titre abrégé: PeerJ
Pays: United States
ID NLM: 101603425

Informations de publication

Date de publication:
2023
Historique:
received: 18 10 2022
accepted: 09 01 2023
entrez: 7 2 2023
pubmed: 8 2 2023
medline: 9 2 2023
Statut: epublish

Résumé

Mathematical modeling is widely used to study within-host viral dynamics. However, to the best of our knowledge, for the case of SARS-CoV-2 such analyses were mainly conducted with the use of viral load data and for the wild type (WT) variant of the virus. In addition, only few studies analyzed models for

Identifiants

pubmed: 36748087
doi: 10.7717/peerj.14828
pii: 14828
pmc: PMC9899056
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e14828

Informations de copyright

© 2023 Staroverov et al.

Déclaration de conflit d'intérêts

Stepan Nersisyan is an employee of Armenian Bioinformatics Institute (ABI).

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Auteurs

Vladimir Staroverov (V)

Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.
Faculty of Mechanics and Mathematics, Lomonosov Moscow State University, Moscow, Russia.

Stepan Nersisyan (S)

Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.
Institute of Molecular Biology, The National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia.
Armenian Bioinformatics Institute (ABI), Yerevan, Armenia.
Current Affiliation: Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States.

Alexei Galatenko (A)

Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.
Faculty of Mechanics and Mathematics, Lomonosov Moscow State University, Moscow, Russia.

Dmitriy Alekseev (D)

Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.
Faculty of Mechanics and Mathematics, Lomonosov Moscow State University, Moscow, Russia.

Sofya Lukashevich (S)

Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.

Fedor Polyakov (F)

Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Nikita Anisimov (N)

Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.

Alexander Tonevitsky (A)

Faculty of Biology and Biotechnology, HSE University, Moscow, Russia.
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

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Classifications MeSH