Hypoxia promotes EV secretion by impairing lysosomal homeostasis in HNSCC through negative regulation of ATP6V1A by HIF-1α.

Humans Extracellular Vesicles / metabolism Head and Neck Neoplasms / metabolism Homeostasis Hypoxia / metabolism Hypoxia-Inducible Factor 1, alpha Subunit / metabolism Lysosomes / metabolism Squamous Cell Carcinoma of Head and Neck / metabolism Tumor Microenvironment Vacuolar Proton-Translocating ATPases / metabolism
ATP6V1A HIF-1α extracellular vesicles hypoxia lysosomes multivesicular bodies

Journal

Journal of extracellular vesicles
ISSN: 2001-3078
Titre abrégé: J Extracell Vesicles
Pays: United States
ID NLM: 101610479

Informations de publication

Date de publication:
02 2023
Historique:
revised: 04 01 2023
received: 17 10 2022
accepted: 26 01 2023
entrez: 7 2 2023
pubmed: 8 2 2023
medline: 9 2 2023
Statut: ppublish

Résumé

Tumour cells under hypoxia tend to modulate the number and contents of extracellular vesicles (EVs) to regulate the tumour microenvironment (TME) and thus promote tumour progression. However, the mechanism of how hypoxia influences the secretion of EVs remains to be elucidated. Here, we confirm the increased production of EVs in head and neck squamous cell carcinoma (HNSCC) cells under hypoxia, where endosome-derived EVs are the main subtype affected by insufficient O

Identifiants

DOI: 10.1002/jev2.12310 PMID: 36748335 PMC: PMC9903130
pubmed: 36748335
doi: 10.1002/jev2.12310
pmc: PMC9903130
doi:

Substances chimiques

ATP6V1A protein, human EC 3.6.1.-
Hypoxia-Inducible Factor 1, alpha Subunit 0
Vacuolar Proton-Translocating ATPases EC 3.6.1.-
HIF1A protein, human 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e12310

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2023 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals, LLC on behalf of the International Society for Extracellular Vesicles.

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Auteurs

Xiaoning Wang (X)

Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR, China.
Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR, China.

Ruoyi Wu (R)

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR, China.

Peisong Zhai (P)

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR, China.

Zheqi Liu (Z)

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR, China.

Ronghui Xia (R)

Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR, China.

Zhen Zhang (Z)

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR, China.

Xing Qin (X)

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR, China.

Chuwen Li (C)

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR, China.

Wantao Chen (W)

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR, China.
Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, National Clinical Research Center of Stomatology, Shanghai, PR, China.

Jiang Li (J)

Department of Oral Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR, China.

Jianjun Zhang (J)

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR, China.
ORCID: 0000-0002-8329-2357

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hypoxia promotes EV secretion by impairing...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Vésicules extracellulaires › Hypoxia promotes EV secretion by impairing...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Hypoxia promotes EV secretion by impairing...
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Hypoxia promotes EV secretion by impairing...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes respiratoires › Hypoxie › Hypoxia promotes EV secretion by impairing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Facteur-1 induit par l'hypoxie › Sous-unité alpha du facteur-1 induit par l'hypoxie › Hypoxia promotes EV secretion by impairing...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › Hypoxia promotes EV secretion by impairing...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Hypoxia promotes EV secretion by impairing...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Hypoxia promotes EV secretion by impairing...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Pompes à protons › Proton-Translocating ATPases › Vacuolar Proton-Translocating ATPases › Hypoxia promotes EV secretion by impairing...