Berberine: Pharmacological features in health, disease and aging.
Aging
Alternative therapy
Antimicrobial activity
Berberine
DNA
Gero-suppression
Microbial modulation
Neurodegenerative and Neuropsychological disorders
Obesity
metabolic effects
Journal
Current medicinal chemistry
ISSN: 1875-533X
Titre abrégé: Curr Med Chem
Pays: United Arab Emirates
ID NLM: 9440157
Informations de publication
Date de publication:
07 Feb 2023
07 Feb 2023
Historique:
received:
22
06
2022
revised:
15
12
2022
accepted:
29
12
2022
entrez:
7
2
2023
pubmed:
8
2
2023
medline:
8
2
2023
Statut:
aheadofprint
Résumé
Berberine is the main active compound of different herbs and is defined as an isoquinoline quaternary botanical alkaloid found in barks and roots of numerous plants. It exhibits a wide range of pharmacological effects, such as anti-obesity and antidiabetic effects. Berberine has antibacterial activity against a variety of microbiota, including many bacterial species, protozoa, plasmodia, fungi, and trypanosomes. This review describes the role of berberine and its metabolic effects. It also discussed how it plays a role in glucose metabolism, fat metabolism, weight loss, how it modulates the gut microbiota, and what are its antimicrobial properties along with its potential side effects with maximal tolerable dosage. Representative studies were considered and analyzed from different scientific databases, including PubMed and Web of Science, for the years 1982-2022. Literature analysis shows that berberine affects many biochemical and pharmacological pathways that theoretically yield a positive effect on health and disease. Berberine exhibits neuroprotective properties in various neurodegenerative and neuropsychological ailments. Despite its low bioavailability after oral administration, a plant alkaloid is a promising tool for several disorders. A possible hypothesis would be the modulation of the gut microbiome. While the evidence concerning the aging process in humans is more limited, preliminary studies have shown positive effects in several models. Berberine could serve as a potential candidate for the treatment of several diseases. Previous literature has provided a basis for scientists to establish clinical trials in humans. However, for obesity, the evidence appears to be sufficient for hands-on use.
Sections du résumé
BACKGROUND
BACKGROUND
Berberine is the main active compound of different herbs and is defined as an isoquinoline quaternary botanical alkaloid found in barks and roots of numerous plants. It exhibits a wide range of pharmacological effects, such as anti-obesity and antidiabetic effects. Berberine has antibacterial activity against a variety of microbiota, including many bacterial species, protozoa, plasmodia, fungi, and trypanosomes.
OBJECTIVE
OBJECTIVE
This review describes the role of berberine and its metabolic effects. It also discussed how it plays a role in glucose metabolism, fat metabolism, weight loss, how it modulates the gut microbiota, and what are its antimicrobial properties along with its potential side effects with maximal tolerable dosage.
METHODS
METHODS
Representative studies were considered and analyzed from different scientific databases, including PubMed and Web of Science, for the years 1982-2022.
RESULTS
RESULTS
Literature analysis shows that berberine affects many biochemical and pharmacological pathways that theoretically yield a positive effect on health and disease. Berberine exhibits neuroprotective properties in various neurodegenerative and neuropsychological ailments. Despite its low bioavailability after oral administration, a plant alkaloid is a promising tool for several disorders. A possible hypothesis would be the modulation of the gut microbiome. While the evidence concerning the aging process in humans is more limited, preliminary studies have shown positive effects in several models.
CONCLUSION
CONCLUSIONS
Berberine could serve as a potential candidate for the treatment of several diseases. Previous literature has provided a basis for scientists to establish clinical trials in humans. However, for obesity, the evidence appears to be sufficient for hands-on use.
Identifiants
pubmed: 36748808
pii: CMC-EPUB-129343
doi: 10.2174/0929867330666230207112539
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
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