Is it bad, is it good, or is IgG4 just misunderstood?
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
31 03 2023
31 03 2023
Historique:
medline:
28
3
2023
pubmed:
8
2
2023
entrez:
7
2
2023
Statut:
ppublish
Résumé
Repeated doses of mRNA vaccines for COVID-19 result in increased proportions of anti-spike antibodies of the IgG4 subclass, which are known to neutralize well and to form mixed immune complexes with IgG1 but, in a pure form, might be less effective than IgG1 or IgG3 antibodies in facilitating opsonization by phagocytes, complement fixation, and NK cell-dependent elimination of infected cells (see related Research Article by Irrgang
Identifiants
pubmed: 36749191
doi: 10.1126/sciimmunol.adg7327
doi:
Substances chimiques
Immunoglobulin G
0
COVID-19 Vaccines
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
eadg7327Subventions
Organisme : NIAID NIH HHS
ID : U19 AI110495
Pays : United States
Commentaires et corrections
Type : CommentOn