Effect of oral Xiao-xian decoction combined with acupoint application therapy on pediatric adenoid hypertrophy: A randomized trial.
Journal
Medicine
ISSN: 1536-5964
Titre abrégé: Medicine (Baltimore)
Pays: United States
ID NLM: 2985248R
Informations de publication
Date de publication:
03 Feb 2023
03 Feb 2023
Historique:
pubmed:
8
2
2023
medline:
10
2
2023
entrez:
7
2
2023
Statut:
ppublish
Résumé
This study aimed to observe the clinical effects of Xiao-xian decoction combined with acupoint application therapy (AAT) for treating pediatric adenoid hypertrophy (AH). We randomly divided 93 AH children into 3 groups: AAT alone; Xiao-xian decoction + AAT; control: Montelukast oral therapy. All participants were treated for a month. We used the traditional Chinese medicine syndrome score to evaluate the clinical efficacy and the obstructive sleep apnea-18 scale to evaluate the quality of life. The major symptoms (nasal congestion, open mouth breathing, snoring, and tongue image) and secondary symptoms of patients treated with Xiao-xian decoction + AAT significantly improved compared to before treatment. The pairwise comparison between groups showed that snoring, tongue, secondary symptoms, and total effective rate of the combined treatment group were better than the control and AAT alone. Additionally, the open-mouth breathing, quality of life, and recurrence rate did not differ after treatment. Oral Xiao-xian decoction combined with AAT significantly improved the symptoms and signs of nasal congestion, open-mouth breathing, snoring, tongue, and quality of life of AH children and may be used as a long-term treatment for AH.
Sections du résumé
BACKGROUND
BACKGROUND
This study aimed to observe the clinical effects of Xiao-xian decoction combined with acupoint application therapy (AAT) for treating pediatric adenoid hypertrophy (AH).
METHODS
METHODS
We randomly divided 93 AH children into 3 groups: AAT alone; Xiao-xian decoction + AAT; control: Montelukast oral therapy. All participants were treated for a month. We used the traditional Chinese medicine syndrome score to evaluate the clinical efficacy and the obstructive sleep apnea-18 scale to evaluate the quality of life.
RESULTS
RESULTS
The major symptoms (nasal congestion, open mouth breathing, snoring, and tongue image) and secondary symptoms of patients treated with Xiao-xian decoction + AAT significantly improved compared to before treatment. The pairwise comparison between groups showed that snoring, tongue, secondary symptoms, and total effective rate of the combined treatment group were better than the control and AAT alone. Additionally, the open-mouth breathing, quality of life, and recurrence rate did not differ after treatment.
CONCLUSION
CONCLUSIONS
Oral Xiao-xian decoction combined with AAT significantly improved the symptoms and signs of nasal congestion, open-mouth breathing, snoring, tongue, and quality of life of AH children and may be used as a long-term treatment for AH.
Identifiants
pubmed: 36749267
doi: 10.1097/MD.0000000000032804
pii: 00005792-202302030-00048
pmc: PMC9901993
doi:
Types de publication
Randomized Controlled Trial
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e32804Informations de copyright
Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.
Déclaration de conflit d'intérêts
The authors have no funding and conflicts of interest to disclose.
Références
Bielicka A, Zielnik-Jurkiewicz B, Podsiadły E, et al. Chlamydia pneumoniae and typical bacteria occurrence in adenoid in children qualified for adenoidectomy. Int J Pediatr Otorhinolaryngol. 2014;78:828–31.
Nosetti L, Zaffanello M, De Bernardi F, et al. Age and upper airway obstruction: a challenge to the clinical approach in pediatric patients. Int J Environ Res Public Health. 2020;17:3531.
Koca CF, Erdem T, Bayindir T. The effect of adenoid hypertrophy on maxillofacial development: an objective photographic analysis. J Otolaryngol Head Neck Surg. 2016;45:48.
Becking BE, Verweij JP, Kalf-Scholte SM, et al. Impact of adenotonsillectomy on the dentofacial development of obstructed children: a systematic review and meta-analysis. Eur J Orthod. 2017;39:509–18.
Niedzielski A, Chmielik LP, Kasprzyk A, et al. Health-related quality of life assessed in children with adenoid hypertrophy. Int J Environ Res Public Health. 2021;18:8935.
Sakarya EU, Bayar Muluk N, Sakalar EG, et al. Use of intranasal corticosteroids in adenotonsillar hypertrophy. J Laryngol Otol. 2017;131:384–90.
Goldbart AD, Goldman JL, Veling MC, et al. Leukotriene modifier therapy for mild sleep-disordered breathing in children. Am J Respir Crit Care Med. 2005;172:364–70.
Wallerstedt SM, Brunlöf G, Sundström A, et al. Montelukast and psychiatric disorders in children. Pharmacoepidemiol Drug Saf. 2009;18:858–64.
Aldea Perona A, García-Sáiz M, Sanz Álvarez E. Psychiatric disorders and montelukast in children: a disproportionality analysis of the VigiBase(®). Drug Saf. 2016;39:69–78.
Sun YL, Zheng HT, Tao JL, et al. Effectiveness and safety of Chinese herbal medicine for pediatric adenoid hypertrophy: a meta-analysis. Int J Pediatr Otorhinolaryngol. 2019;119:79–85.
Liu X, Jiang Z, Xiao Z, et al. Meta-analysis of Chinese medicine in the treatment of adenoidal hypertrophy in children. Eur Arch Otorhinolaryngol. 2019;276:203–08.
Wang P, Kong W, Shan Y. The efficacy and safety of Chinese herbal compound or combined with western medicine for pediatric adenoidal hypertrophy: a protocol for systematic review and meta-analysis. Medicine (Baltim). 2020;99:e22023.
Wang BX, Feng LQ. Effect analysis of self-designed Tongqiao Decoction combined with acupoint application on children with adenoid hypertrophy. Doctor. 2022;7:99–101.
Liu B, Qiu QZ. Investigation on the clinical efficacy of modified Xiaofeng Sanjie decoction in the treatment of pediatric adenoid hypertrophy based on the theory of latent pathogens. J Guangzhou Univ Trad Chin Med. 2022;39:1787–92.
Pereira L, Monyror J, Almeida FT, et al. Prevalence of adenoid hypertrophy: a systematic review and meta-analysis. Sleep Med Rev. 2018;38:101–12.
Xiao L, Su S, Liang J, et al. Analysis of the risk factors associated with obstructive sleep apnea syndrome in chinese children. Front Pediatr. 2022;10:900216.
Calvo-Henriquez C, Branco AM, Lechien JR, et al. Assessing the effect of adenoidectomy on nasal resistance and airflow. a systematic review and meta-analysis. Int J Pediatr Otorhinolaryngol. 2021;151:110969.
Colavita L, Miraglia Del Giudice M, Stroscio G, et al. Allergic rhinitis and adenoid hypertrophy in children: is adenoidectomy always really useful? J Biol Regul Homeost Agents. 2015;29(2 Suppl 1):58–63.
Naqi SA, Ashfaq AH, Umar MA, et al. Clinical outcome of montelukast sodium in children with adenoid hypertrophy. Pak J Med Sci. 2021;37:362–66.
Shokouhi F, Meymaneh Jahromi A, Majidi MR, et al. Montelukast in adenoid hypertrophy: its effect on size and symptoms. Iran J Otorhinolaryngol. 2015;27:443–8.
Brouillette RT, Manoukian JJ, Ducharme FM, et al. Efficacy of fluticasone nasal spray for pediatric obstructive sleep apnea. J Pediatr. 2001;138:838–44.
Zhang L, Mendoza-Sassi RA, César JA, et al. Intranasal corticosteroids for nasal airway obstruction in children with moderate to severe adenoidal hypertrophy. Cochrane Database Syst Rev. 2008;2008:CD006286.
Yang XC, Yin T, Gao Q, et al. The immunomodulatory effect of acupoint application for childhood asthma: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2015;2015:896247.
Shi Y, Wu L, Zhang N, et al. Exploring the mechanism of pericarpium citri reticulatae and fritillaria thunbergii in the treatment of adenoid hypertrophy based on network pharmacology and molecular docking. J Contemporary Med Pract. 2022;4:123–30.
Qi R, Kang Y, Li X, et al. Forsythiasides-rich extract from forsythiae fructus inhibits mast cell degranulation by enhancing mitochondrial Ca2+ uptake. Front Pharmacol. 2021;12:696729.
Wei YY, Hu TJ, Su ZJ, et al. Immunomodulatory and antioxidant effects of carboxymethylpachymaran on the mice infected with PCV2. Int J Biol Macromol. 2012;50:713–9.
Bai J, Qi J, Yang L, et al. A comprehensive review on ethnopharmacological, phytochemical, pharmacological and toxicological evaluation, and quality control of Pinellia ternata (Thunb.) Breit. J Ethnopharmacol. 2022;298:115650.
Tu W, Chen X, Wu Q, et al. Acupoint application inhibits nerve growth factor and attenuates allergic inflammation in allergic rhinitis model rats. J Inflamm (Lond). 2020;17:4.