The Role of Lung Resident Mesenchymal Stromal Cells in the Pathogenesis and Repair of Chronic Lung Disease.
bronchiolitis obliterans
bronchopulmonary dysplasia
chronic lung disease
chronic obstructive pulmonary disease
idiopathic pulmonary fibrosis
mesenchymal stromal cells
Journal
Stem cells (Dayton, Ohio)
ISSN: 1549-4918
Titre abrégé: Stem Cells
Pays: England
ID NLM: 9304532
Informations de publication
Date de publication:
15 05 2023
15 05 2023
Historique:
received:
01
08
2022
accepted:
26
01
2023
medline:
16
5
2023
pubmed:
8
2
2023
entrez:
7
2
2023
Statut:
ppublish
Résumé
Mesenchymal stromal/stem cells are multipotent adult cells that can be extracted from numerous tissues, including the lungs. Lung-resident MSCs (LR-MSCs) are localized to perivascular spaces where they act as important regulators of pulmonary homeostasis, mediating the balance between lung injury/damage and repair processes. LR-MSCs support the integrity of the lung tissue via modulation of the immune response and release of trophic factors. However, in the context of chronic lung diseases, the ability of LR-MSCs to maintain pulmonary homeostasis and facilitate repair is diminished. In this setting, LR-MSC can contribute to the pathogenesis of disease, through their altered secretory and immunomodulatory properties. In addition, they are capable of differentiating into myofibroblasts, thereby contributing to the fibrotic aspects of numerous lung diseases. For example, in idiopathic pulmonary fibrosis, a variety of factors can stimulate their differentiation into myofibroblasts including tumor necrosis factor-α (TNF-(α), transforming growth factor-β1 (TGF-β1), endoplasmic reticulum (ER) stress, Hedgehog (HH), and Wingless/integrated (Wnt) signaling. Here, we review the current literature on the characterization of LR-MSCs and describe their roles in pulmonary homeostasis/repair and in the pathogenesis of chronic lung disease.
Identifiants
pubmed: 36749355
pii: 7030853
doi: 10.1093/stmcls/sxad014
pmc: PMC10183969
doi:
Substances chimiques
Hedgehog Proteins
0
Types de publication
Review
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
431-443Subventions
Organisme : Medical Research Council
ID : MR/S009426/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2023. Published by Oxford University Press.
Références
Cell Death Dis. 2016 Jan 21;7:e2062
pubmed: 26794657
Cell Stem Cell. 2015 Jan 8;16(1):51-66
pubmed: 25465115
BMJ Open Respir Res. 2014 May 17;1(1):e000027
pubmed: 25478178
Am J Respir Crit Care Med. 2013 Oct 1;188(7):820-30
pubmed: 23924232
Stem Cells. 2014 Jun;32(6):1408-19
pubmed: 24578244
Trends Mol Med. 2019 Feb;25(2):149-163
pubmed: 30711482
Stem Cells Transl Med. 2022 Mar 3;11(1):2-13
pubmed: 35641163
Nat Med. 2013 Jan;19(1):35-42
pubmed: 23296015
Gene. 2023 Apr 5;859:147142
pubmed: 36603696
Sci Rep. 2016 Jul 22;6:30122
pubmed: 27444321
J Orthop Res. 2017 Jun;35(6):1151-1159
pubmed: 28294393
Cells. 2021 Dec 09;10(12):
pubmed: 34943975
J Cell Physiol. 2018 Mar;233(3):2409-2419
pubmed: 28731277
J Clin Invest. 2011 Nov;121(11):4409-19
pubmed: 21985786
Cell Transplant. 2012;21(1):175-89
pubmed: 21294955
Stem Cells Dev. 2011 Jan;20(1):53-66
pubmed: 20528146
Commun Biol. 2021 May 20;4(1):601
pubmed: 34017045
Stem Cell Res. 2013 Nov;11(3):1222-33
pubmed: 24029687
Cell Biol Int. 2014 Apr;38(4):405-11
pubmed: 24403246
Stem Cells. 2007 Jul;25(7):1610-7
pubmed: 17395773
Cell Physiol Biochem. 2017;43(6):2155-2169
pubmed: 29069643
Cancers (Basel). 2021 Sep 16;13(18):
pubmed: 34572864
Am J Pathol. 2011 Jun;178(6):2461-9
pubmed: 21641374
Stem Cells Dev. 2018 Aug 15;27(16):1109-1124
pubmed: 29957134
Cytotherapy. 2019 Oct;21(10):1019-1024
pubmed: 31526643
Stem Cells Int. 2016;2016:4285215
pubmed: 26823669
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8639-43
pubmed: 20421459
Stem Cells. 2011 Apr;29(4):725-35
pubmed: 21312316
Cytotherapy. 2013 Jun;15(6):641-8
pubmed: 23570660
Cell Commun Signal. 2022 Jul 14;20(1):104
pubmed: 35836260
Stem Cells. 2010 Dec;28(12):2229-38
pubmed: 20945332
Front Immunol. 2019 Nov 08;10:2474
pubmed: 31781089
Stem Cells. 2022 May 27;40(5):479-492
pubmed: 35445270
Cells. 2021 Oct 23;10(11):
pubmed: 34831082
Cell Stem Cell. 2013 Oct 3;13(4):392-402
pubmed: 24094322
Arthritis Rheumatol. 2016 Apr;68(4):1013-25
pubmed: 26474311
Stem Cell Res Ther. 2018 Sep 26;9(1):257
pubmed: 30257725
Differentiation. 2022 May-Jun;125:35-44
pubmed: 35487030
Sci Rep. 2018 Jul 24;8(1):11167
pubmed: 30042393
Am J Respir Cell Mol Biol. 2019 May;60(5):592-600
pubmed: 30562051
Cytotherapy. 2006;8(4):315-7
pubmed: 16923606
Antioxid Redox Signal. 2021 Jul 20;35(3):204-216
pubmed: 33167666
PLoS One. 2020 Mar 6;15(3):e0229521
pubmed: 32142526
Cell Stem Cell. 2008 Sep 11;3(3):301-13
pubmed: 18786417
Am J Physiol Cell Physiol. 2014 Oct 15;307(8):C684-98
pubmed: 25122876
Signal Transduct Target Ther. 2021 Sep 8;6(1):339
pubmed: 34497264
Dev Cell. 2010 Jan 19;18(1):8-23
pubmed: 20152174
J Immunol. 2007 Aug 1;179(3):1595-604
pubmed: 17641026
Stem Cells Int. 2017;2017:5173732
pubmed: 28286525
Stem Cell Res Ther. 2016 Jul 12;7(1):91
pubmed: 27406134
Stem Cells. 2012 Sep;30(9):2010-9
pubmed: 22782863
Stem Cells Dev. 2016 Dec 15;25(24):1843-1852
pubmed: 27702398
Stem Cells Int. 2018 Mar 14;2018:9492038
pubmed: 29731780
Int J Mol Med. 2017 Apr;39(4):775-782
pubmed: 28290609
Compr Physiol. 2021 Jun 30;11(3):2227-2247
pubmed: 34190345
Blood. 2005 Feb 15;105(4):1815-22
pubmed: 15494428
Sci Rep. 2016 Feb 12;6:21642
pubmed: 26869337
Cell Tissue Kinet. 1970 Oct;3(4):393-403
pubmed: 5523063
Bone Marrow Transplant. 1995 Oct;16(4):557-64
pubmed: 8528172
Stem Cells. 2016 Aug;34(8):2210-23
pubmed: 27059413
Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6503-8
pubmed: 21464310
Respir Res. 2010 Sep 21;11:127
pubmed: 20858250
Am J Respir Crit Care Med. 2012 Jan 1;185(1):77-84
pubmed: 21940790
Inflammation. 2019 Feb;42(1):199-210
pubmed: 30187337
Stem Cells. 2008 Sep;26(9):2287-99
pubmed: 18566331
Stem Cells. 2008 Jan;26(1):212-22
pubmed: 17932417
Cell Stem Cell. 2017 Aug 3;21(2):166-177
pubmed: 28777943
Pediatrics. 2010 Nov;126(5):e1127-33
pubmed: 20937656
Am J Respir Cell Mol Biol. 2011 Oct;45(4):809-16
pubmed: 21378261
Front Genet. 2018 Sep 25;9:418
pubmed: 30319693
J Transl Med. 2018 Jul 27;16(1):212
pubmed: 30053821
Transplantation. 2011 Jul 27;92(2):155-62
pubmed: 21701423
Respir Res. 2014 Oct 03;15:118
pubmed: 25272959
Sci Rep. 2016 Nov 21;6:37445
pubmed: 27869174
Nat Med. 2012 Apr 15;18(5):759-65
pubmed: 22504485
Stem Cells Transl Med. 2017 Dec;6(12):2173-2185
pubmed: 29076267
Thorax. 2012 Jun;67(6):533-9
pubmed: 22250097
Lab Invest. 2005 Aug;85(8):962-71
pubmed: 15924148
Am J Respir Cell Mol Biol. 2019 Nov;61(5):575-583
pubmed: 30978114
Stem Cells Dev. 2011 Oct;20(10):1779-92
pubmed: 21585237
Nat Cell Biol. 2020 Nov;22(11):1295-1306
pubmed: 33046884
Nat Rev Immunol. 2008 Sep;8(9):726-36
pubmed: 19172693
Cytotherapy. 2008;10(2):140-51
pubmed: 18368593
Lab Invest. 2020 Mar;100(3):363-377
pubmed: 31541181
Stem Cell Res Ther. 2020 Jul 16;11(1):292
pubmed: 32678014
Sci Rep. 2020 Jul 7;10(1):11162
pubmed: 32636398
Cell Stem Cell. 2008 Sep 11;3(3):229-30
pubmed: 18786406
Am J Respir Crit Care Med. 2017 Nov 15;196(10):1275-1286
pubmed: 28598224
Stem Cells Transl Med. 2021 Jan;10(1):128-143
pubmed: 32830458
iScience. 2021 May 19;24(6):102551
pubmed: 34151224
Antioxid Redox Signal. 2014 Nov 1;21(13):1849-62
pubmed: 24350665