Systematic review to estimate the prevalence of inflammatory rheumatic diseases in Germany.
Systematisches Review zur Schätzung der Prävalenz entzündlich-rheumatischer Erkrankungen in Deutschland – Englische Version.
Connective tissue diseases
Juvenile idiopathic arthritis
Rheumatoid arthritis
Spondyloarthritis
Vasculitis
Journal
Zeitschrift fur Rheumatologie
ISSN: 1435-1250
Titre abrégé: Z Rheumatol
Pays: Germany
ID NLM: 0414162
Informations de publication
Date de publication:
07 Feb 2023
07 Feb 2023
Historique:
accepted:
18
11
2022
entrez:
7
2
2023
pubmed:
8
2
2023
medline:
8
2
2023
Statut:
aheadofprint
Résumé
This study aimed to update the prevalence estimates of inflammatory rheumatic diseases (IRD) in Germany. A systematic literature search in PubMed and Web of Science (last search 08 November 2022) identified original articles (regional and nationwide surveys and claims data analyses for arthritides, connective tissue diseases, and vasculitides) on prevalences for the period 2014-2022. Data sources, collection period, case definition, and risk of bias are reported. Prevalences were estimated from available national data, with consideration of international data. Screening by two authors yielded 263 hits, of which 18 claims data analyses and 2 surveys met the inclusion criteria. Prevalences ranged from 0.42 to 1.85% (rheumatoid arthritis), 0.32-0.5% (ankylosing spondylitis), 0.11-0.32% (psoriatic arthritis), 0.037-0.14% (systemic lupus erythematosus), 0.07-0.77% (Sjögren's disease/sicca syndrome), 0.14-0.15% (polymyalgia rheumatica, ≥ 40 years), 0.04-0.05% (giant cell arteritis, ≥ 50 years), and 0.015-0.026% (ANCA-associated vasculitis). The risk of bias was moderate in 13 and high in 7 studies. Based on the results, we estimate the prevalence of IRD in Germany to be 2.2-3.0%, which corresponds to approximately 1.5-2.1 million affected individuals. The prevalence of juvenile idiopathic arthritis was reported to be around 0.10% (0.07-0.10%) of 0-18-year-olds, corresponding to about 14,000 children and adolescents in Germany. This systematic review shows an increase in the prevalence of IRD in Germany, which is almost exclusively based on claims data analyses. In the absence of multistage population studies, the available data are, overall, uncertain sources for prevalence estimates, with a moderate to high risk of bias. ZIELSETZUNG: Ziel der Arbeit war eine aktualisierte Schätzung der Prävalenz entzündlich-rheumatischer Erkrankungen (ERE) in Deutschland. Mit einer systematischen Literaturrecherche in den Datenbanken PubMed und Web of Science (letzte Suche am 08.11.2022) wurden Originalartikel (regionale und bundesweite Surveys und Routinedatenanalysen für Arthritiden, Kollagenosen und Vaskulitiden) zur ERE-Prävalenz für den Zeitraum 2014–2022 identifiziert. Datenquellen, Erhebungszeitraum, Diagnosedefinition und das Risiko einer Verzerrung werden mitgeteilt. Die Prävalenzen wurden anhand der verfügbaren nationalen Daten unter Berücksichtigung internationaler Angaben geschätzt. Die Suche durch 2 Autorinnen ergab 263 Treffer, von denen 18 Routinedatenanalysen und 2 Surveys die Einschlusskriterien erfüllten. Die Prävalenzangaben lagen bei 0,42–1,85 % (rheumatoide Arthritis), 0,32–0,5 % (ankylosierende Spondylitis), 0,11–0,32 % (Psoriasisarthritis), 0,037–0,14 % (systemischer Lupus erythematodes), 0,07–0,77 % (Sjögren‑/Sicca-Syndrom), 0,14–0,15 % (Polymyalgia rheumatica, ab 40 Jahre), 0,04–0,05 % (Riesenzellarteriitis, ab 50 Jahre) und 0,015–0,026 % (mit antineutrophilen zytoplasmatischen Antikörpern [ANCA-]assoziierte Vaskulitis). Das Bias-Risiko war in 13 Studien moderat, in 7 Studien hoch. Anhand dieser Ergebnisse schätzen die Autorinnen die Prävalenz von ERE in Deutschland auf 2,2–3,0 %. Dies entspricht in etwa 1,5–2,1 Mio. Betroffenen. Die Prävalenz der juvenilen idiopathischen Arthritis wurde mit etwa 0,10 % (0,07–0,13 %) der 0‑ bis 18-Jährigen angegeben, was etwa 14.000 Kindern und Jugendlichen in Deutschland entspricht. Dieses systematische Review zeigt einen Anstieg der Prävalenzen von ERE in Deutschland, basiert jedoch fast ausschließlich auf Routinedatenanalysen. In Ermangelung mehrstufiger Bevölkerungsstudien sind die vorliegenden Daten bei moderatem bis hohem Verzerrungsrisiko insgesamt unsichere Quellen für Prävalenzschätzungen.
Autres résumés
Type: Publisher
(ger)
ZIELSETZUNG: Ziel der Arbeit war eine aktualisierte Schätzung der Prävalenz entzündlich-rheumatischer Erkrankungen (ERE) in Deutschland.
Identifiants
pubmed: 36749363
doi: 10.1007/s00393-022-01302-5
pii: 10.1007/s00393-022-01302-5
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2023. The Author(s).
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