The cerebellum is causally involved in episodic memory under aging.
Cerebellum
Episodic memory decline
Neurostimulation
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
Aug 2023
Aug 2023
Historique:
received:
21
10
2022
accepted:
17
01
2023
medline:
27
11
2023
pubmed:
8
2
2023
entrez:
7
2
2023
Statut:
ppublish
Résumé
Episodic memory decline is a major signature of both normal and pathological aging. Many neural regions have been implicated in the processes subserving both episodic memory and typical aging decline. Here, we demonstrate that the cerebellum is causally involved episodic memory under aging. We show that a 12-day neurostimulation program delivered to the right cerebellum led to improvements in episodic memory performance under healthy aging that long outlast the stimulation period - healthy elderly individuals show episodic memory improvement both immediately after the intervention program and in a 4-month follow-up. These results demonstrate the causal relevance of the cerebellum in processes associated with long-term episodic memory, potentially highlighting its role in regulating and maintaining cognitive processing. Moreover, they point to the importance of non-pharmacological interventions that prevent or diminish cognitive decline in healthy aging.
Identifiants
pubmed: 36749471
doi: 10.1007/s11357-023-00738-0
pii: 10.1007/s11357-023-00738-0
pmc: PMC10651631
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2267-2287Subventions
Organisme : Fundação Bial
ID : 495/14
Organisme : H2020 European Research Council
ID : 802553
Organisme : Fundação para a Ciência e a Tecnologia
ID : SFRH/BD/136029/2018
Organisme : Fundação para a Ciência e a Tecnologia
ID : 2020.00524.CEECIND
Organisme : Fundação para a Ciência e a Tecnologia
ID : PTDC/PSI-GER/30757/2017
Informations de copyright
© 2023. The Author(s).
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