Development of a Slow-Degrading Polymerized Curcumin Coating for Intracortical Microelectrodes.

Rats Animals Microelectrodes Curcumin / pharmacology Electrodes, Implanted Neurons Polymers
coating curcumin drug delivery electrode polyethylene glycol polyprodrug

Journal

ACS applied bio materials
ISSN: 2576-6422
Titre abrégé: ACS Appl Bio Mater
Pays: United States
ID NLM: 101729147

Informations de publication

Date de publication:
20 02 2023
Historique:
pubmed: 8 2 2023
medline: 25 2 2023
entrez: 7 2 2023
Statut: ppublish

Résumé

Intracortical microelectrodes are used with brain-computer interfaces to restore lost limb function following nervous system injury. While promising, recording ability of intracortical microelectrodes diminishes over time due, in part, to neuroinflammation. As curcumin has demonstrated neuroprotection through anti-inflammatory activity, we fabricated a 300 nm-thick intracortical microelectrode coating consisting of a polyurethane copolymer of curcumin and polyethylene glycol (PEG), denoted as poly(curcumin-PEG

Identifiants

DOI: 10.1021/acsabm.2c00969 PMID: 36749645
pubmed: 36749645
doi: 10.1021/acsabm.2c00969
doi:

Substances chimiques

Curcumin IT942ZTH98
Polymers 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

806-818

Auteurs

Alexis M Ziemba (AM)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Neuroscience Program, Department of Biological Sciences, Smith College, Northampton 01063, Massachusetts, United States.

Mary Clare Crochiere Woodson (MCC)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.

Jessica L Funnell (JL)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.

Douglas Wich (D)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.

Bailey Balouch (B)

Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.

Deniz Rende (D)

Center for Materials, Devices, and Integrated Systems, Rensselaer Polytechnic Institute, 110 8th Street, Troy 12180-3590, New York, United States.

Dahlia N Amato (DN)

Department of Materials Science and Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.

Jonathan Bao (J)

Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.

Ingrid Oprea (I)

Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.

Dominica Cao (D)

Neuroscience Program, Department of Biological Sciences, Smith College, Northampton 01063, Massachusetts, United States.

Neda Bajalo (N)

Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.

Evon S Ereifej (ES)

Veteran Affairs Ann Arbor Healthcare System, Ann Arbor 48104, Michigan, United States.
Department of Biomedical Engineering, University of Michigan, Ann Arbor 48104, Michigan, United States.
Department of Neurology, University of Michigan, Ann Arbor 48104, Michigan, United States.
United States Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland 44106, Ohio, United States.

Jeffrey R Capadona (JR)

United States Advanced Platform Technology Center, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland 44106, Ohio, United States.
Department of Biomedical Engineering, Case Western Reserve University, Cleveland 44106, Ohio, United States.

Edmund F Palermo (EF)

Department of Materials Science and Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
ORCID: 0000-0003-3656-787X

Ryan J Gilbert (RJ)

Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
Center for Biotechnology and Interdisciplinary Sciences, Rensselaer Polytechnic Institute, Troy 12180-3590, New York, United States.
ORCID: 0000-0002-3501-6753

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Development of a Slow-Degrading Polymerized...
questionsmedicales.fr › Eucaryotes › Animaux › Development of a Slow-Degrading Polymerized...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures électriques › Électrodes › Microélectrodes › Development of a Slow-Degrading Polymerized...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Diarylheptanoïdes › Curcumine › Development of a Slow-Degrading Polymerized...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Électrodes implantées › Development of a Slow-Degrading Polymerized...
questionsmedicales.fr › Cellules › Neurones › Development of a Slow-Degrading Polymerized...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Development of a Slow-Degrading Polymerized...