USP47 deubiquitylates Groucho/TLE to promote Wnt-β-catenin signaling.

Animals Humans beta Catenin / metabolism Drosophila Drosophila melanogaster / metabolism Transcription Factors / metabolism Ubiquitin-Protein Ligases / metabolism Wnt Signaling Pathway Xenopus

Journal

Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400

Informations de publication

Date de publication:
07 02 2023
Historique:
entrez: 7 2 2023
pubmed: 8 2 2023
medline: 10 2 2023
Statut: ppublish

Résumé

The Wnt-β-catenin signal transduction pathway is essential for embryonic development and adult tissue homeostasis. Wnt signaling converts TCF from a transcriptional repressor to an activator in a process facilitated by the E3 ligase XIAP. XIAP-mediated monoubiquitylation of the transcriptional corepressor Groucho (also known as TLE) decreases its affinity for TCF, thereby allowing the transcriptional coactivator β-catenin to displace it on TCF. Through a genome-scale screen in cultured

Identifiants

DOI: 10.1126/scisignal.abn8372 PMID: 36749823 PMC: PMC10038201
pubmed: 36749823
doi: 10.1126/scisignal.abn8372
pmc: PMC10038201
mid: NIHMS1879160
doi:

Substances chimiques

beta Catenin 0
Transcription Factors 0
Ubiquitin-Protein Ligases EC 2.3.2.27
USP47 protein, human 0
TLE3 protein, human 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabn8372

Subventions

Organisme : NIDDK NIH HHS
ID : R00 DK103126
Pays : United States
Organisme : NCI NIH HHS
ID : K12 CA090625
Pays : United States
Organisme : NCI NIH HHS
ID : K08 CA240901
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122516
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009213
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA219189
Pays : United States
Organisme : NIEHS NIH HHS
ID : F30 ES016504
Pays : United States
Organisme : NIDDK NIH HHS
ID : K99 DK103126
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA272875
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008554
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM136233
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM147128
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA244188
Pays : United States

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Auteurs

Sara Kassel (S)

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0002-6612-4167

Alison J Hanson (AJ)

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0002-9498-1238

Hassina Benchabane (H)

Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.
ORCID: 0000-0003-0771-2249

Kenyi Saito-Diaz (K)

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0002-9829-2536

Carly R Cabel (CR)

Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, Tucson, AZ 85724, USA.
ORCID: 0000-0001-9865-1810

Lily Goldsmith (L)

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0002-3323-2428

Muhammad Taha (M)

Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.
ORCID: 0000-0001-7272-1024

Aksheta Kanuganti (A)

Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.
ORCID: 0000-0002-1256-7173

Victoria H Ng (VH)

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
ORCID: 0000-0003-2344-8468

George Xu (G)

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Fei Ye (F)

Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
ORCID: 0000-0001-6472-5076

Julia Picker (J)

Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.
ORCID: 0000-0003-3312-1645

Fillip Port (F)

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.
ORCID: 0000-0002-5157-4835

Michael Boutros (M)

German Cancer Research Center (DKFZ), Division Signaling and Functional Genomics and Department of Cell and Molecular Biology, Medical Faculty Mannheim, Heidelberg University, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.
ORCID: 0000-0002-9458-817X

Vivian L Weiss (VL)

Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
ORCID: 0000-0003-0874-3207

David J Robbins (DJ)

Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.
ORCID: 0000-0003-0190-2973

Curtis A Thorne (CA)

Department of Cellular and Molecular Medicine, University of Arizona Cancer Center, Tucson, AZ 85724, USA.
ORCID: 0000-0002-8711-8292

Yashi Ahmed (Y)

Department of Molecular and Systems Biology and the Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth College, Hanover, NH 03755, USA.
ORCID: 0000-0002-7472-6010

Ethan Lee (E)

Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA.
Vanderbilt Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
ORCID: 0000-0001-8405-6156

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › USP47 deubiquitylates Groucho/TLE to promote...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › USP47 deubiquitylates Groucho/TLE to promote...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › bêta-Caténine › USP47 deubiquitylates Groucho/TLE to promote...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › USP47 deubiquitylates Groucho/TLE to promote...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › USP47 deubiquitylates Groucho/TLE to promote...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › USP47 deubiquitylates Groucho/TLE to promote...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Ligases › Ubiquitin-protein ligase complexes › Ubiquitin-protein ligases › USP47 deubiquitylates Groucho/TLE to promote...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Voie de signalisation Wnt › USP47 deubiquitylates Groucho/TLE to promote...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Amphibiens › Anura › Pipidae › Xenopus › USP47 deubiquitylates Groucho/TLE to promote...