Thromboelastography demonstrates progressive hypercoagulability in COVID-19 patients admitted to ICU with respiratory failure.
COVID-19
Thromboelastography
Journal
Journal of the Intensive Care Society
ISSN: 1751-1437
Titre abrégé: J Intensive Care Soc
Pays: England
ID NLM: 101538668
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
entrez:
8
2
2023
pubmed:
9
2
2023
medline:
9
2
2023
Statut:
ppublish
Résumé
Thromboembolic complications are associated with COVID-19 owing to the hypercoagulable nature of the disease. Although patients with COVID-19 often have higher levels of fibrinogen and D-dimers, hypercoagulability has been attributed to various other factors too. In this prospective observational study conducted between April 2020 and June 2020, we compared coagulation parameters using thromboelastography in COVID-19 patients to non-COVID-19 patients admitted to ICU with respiratory failure. This study demonstrated a significant difference between the cohorts in functional fibrinogen (CFF) progressively from third day of ICU admission whilst there was no difference in the Clauss fibrinogen levels. COVID-19 patients also demonstarted supranormal R time indicating hypocoagulability. These mixed coagulation changes suggest targeting fibrinogen or platelets may prevent thromboembolic complications in COVID-19.
Identifiants
pubmed: 36751352
doi: 10.1177/17511437211026787
pii: 10.1177_17511437211026787
pmc: PMC9679900
doi:
Types de publication
Journal Article
Langues
eng
Pagination
506-509Informations de copyright
© The Intensive Care Society 2021.
Déclaration de conflit d'intérêts
The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Clin Rheumatol. 2020 Sep;39(9):2529-2543
pubmed: 32654082
J Thromb Thrombolysis. 2020 Aug;50(2):281-286
pubmed: 32394236
J Thromb Haemost. 2020 Aug;18(8):1995-2002
pubmed: 32369666
Crit Care Med. 2020 Sep;48(9):1319-1326
pubmed: 32618696
Transl Res. 2020 Jun;220:1-13
pubmed: 32299776
Clin Chem Lab Med. 2020 Jun 25;58(7):1116-1120
pubmed: 32172226
JAMA Netw Open. 2020 Jun 1;3(6):e2011192
pubmed: 32501489
Circulation. 2020 Jul 14;142(2):184-186
pubmed: 32330083