Using organ perfusion to optimize donor livers.
Journal
Current opinion in organ transplantation
ISSN: 1531-7013
Titre abrégé: Curr Opin Organ Transplant
Pays: United States
ID NLM: 9717388
Informations de publication
Date de publication:
01 04 2023
01 04 2023
Historique:
pubmed:
9
2
2023
medline:
7
3
2023
entrez:
8
2
2023
Statut:
ppublish
Résumé
The shortage of donor organs has led to the use of marginal extended criteria donor (ECD) livers to increase access to liver transplant. Ex-vivo machine perfusion allows for treatment and assessment of organs during preservation, potentially facilitating safe use of ECD livers at risk for worse clinical outcomes. This article reviews the latest published literature on the application of ex-vivo machine perfusion technologies in liver transplantation. Multiple randomized controlled trials on the use of hypothermic machine perfusion (HMP) and normothermic machine perfusion (NMP) have been published in the past 5 years demonstrating improved graft function and decreased biliary complications after machine perfusion. Novel applications of machine perfusion include pretransplant organ viability testing, expansion to pediatric transplant, and prolonged preservation. There is now a body of evidence that HMP and NMP treatment improves clinical outcomes in ECD livers. There is a wide horizon for future applications of these preservation techniques to further optimize donor livers and to facilitate more liver transplants for those on the waitlist.
Identifiants
pubmed: 36752282
doi: 10.1097/MOT.0000000000001054
pii: 00075200-202304000-00006
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
95-103Informations de copyright
Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.
Références
Organ Procurement and Transplantation Network. National Data [Internet]. Health Resources and Services Administration, US Department of Health and Human Services; 2022 [cited 2022 Dec 30]. Available from: https://optn.transplant.hrsa.gov/data/view-data-reports/national-data/ .
Attia M, Silva MA, Mirza DF. The marginal liver donor--an update. Transpl Int 2008; 21:713–724.
Feng S, Goodrich NP, Bragg-Gresham JL, et al. Characteristics associated with liver graft failure: the concept of a donor risk index. Am J Transplant 2006; 6:783–790.
Olthoff KM, Kulik L, Samstein B, et al. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transpl 2010; 16:943–949.
Jay CL, Lyuksemburg V, Ladner DP, et al. Ischemic cholangiopathy after controlled donation after cardiac death liver transplantation: a meta-analysis. Ann Surg 2011; 253:259–264.
Savoye E, Macher MA, Videcoq M, et al. Evaluation of outcomes in renal transplantation with hypothermic machine perfusion for the preservation of kidneys from expanded criteria donors. Clin Transplant 2019; 33:e13536.
Moers C, Smits JM, Maathuis MH, et al. Machine perfusion or cold storage in deceased-donor kidney transplantation. N Engl J Med 2009; 360:7–19.
Guarrera JV, Henry SD, Samstein B, et al. Hypothermic machine preservation in human liver transplantation: the first clinical series. Am J Transplant 2010; 10:372–381.
Guarrera JV, Henry SD, Samstein B, et al. Hypothermic machine preservation facilitates successful transplantation of “orphan” extended criteria donor livers. Am J Transplant 2015; 15:161–169.
Cotter TG, Odenwald MA, Perez-Gutierrez A, et al. Preservation solutions for static cold storage in donation after circulatory death and donation after brain death liver transplantation in the United States. Liver Transpl 2022; 28:1454–1462.
Schlegel A, Muller X, Mueller M, et al. Hypothermic oxygenated perfusion protects from mitochondrial injury before liver transplantation. EBioMedicine 2020; 60:103014.
Patrono D, Surra A, Catalano G, et al. Hypothermic oxygenated machine perfusion of liver grafts from brain-dead donors. Sci Rep 2019; 9:9337.
Dutkowski P, Polak WG, Muiesan P, et al. First comparison of hypothermic oxygenated perfusion versus static cold storage of human donation after cardiac death liver transplants: an international-matched case analysis. Ann Surg 2015; 262:764–770.
van Rijn R, Schurink IJ, de Vries Y, et al. DHOPE-DCD Trial Investigators. Hypothermic machine perfusion in liver transplantation - a randomized trial. N Engl J Med 2021; 384:1391–1401.
Czigany Z, Pratschke J, Fronek J, et al. Hypothermic oxygenated machine perfusion reduces early allograft injury and improves posttransplant outcomes in extended criteria donation liver transplantation from donation after brain death: results from a multicenter randomized controlled trial (HOPE ECD-DBD). Ann Surg 2021; 274:705–712.
Patrono D, Cussa D, Sciannameo V, et al. Outcome of liver transplantation with grafts from brain-dead donors treated with dual hypothermic oxygenated machine perfusion, with particular reference to elderly donors. Am J Transplant 2022; 22:1382–1395.
Ravaioli M, Maroni L, Angeletti A, et al. Hypothermic oxygenated perfusion versus static cold storage for expanded criteria donors in liver and kidney transplantation: protocol for a single-center randomized controlled trial. JMIR Res Protoc 2020; 9:e13922.
Ravaioli M, Germinario G, Dajti G, et al. Hypothermic oxygenated perfusion in extended criteria donor liver transplantation-a randomized clinical trial. Am J Transplant 2022; 22:2401–2408.
Muller X, Schlegel A, Kron P, et al. Novel real-time prediction of liver graft function during hypothermic oxygenated machine perfusion before liver transplantation. Ann Surg 2019; 270:783–790.
Patrono D, Catalano G, Rizza G, et al. Perfusate analysis during dual hypothermic oxygenated machine perfusion of liver grafts: correlations with donor factors and early outcomes. Transplantation 2020; 104:1929–1942.
Mueller M, Kalisvaart M, O’Rourke J, et al. Hypothermic Oxygenated Liver Perfusion (HOPE) prevents tumor recurrence in liver transplantation from donation after circulatory death. Ann Surg 2020; 272:759–765.
Chen H, Lu D, Yang X, et al. One shoot, two birds: alleviating inflammation caused by ischemia/reperfusion injury to reduce the recurrence of hepatocellular carcinoma. Front Immunol 2022; 13:879552.
Bruggenwirth IMA, Mueller M, Lantinga VA, et al. Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: a European observational cohort study. Am J Transplant 2022; 22:1842–1851.
Cussa D, Patrono D, Catalano G, et al. Use of dual hypothermic oxygenated machine perfusion to recover extended criteria pediatric liver grafts. Liver Transpl 2020; 26:835–839.
Diamond IR, Fecteau A, Millis JM, et al. SPLIT Research Group. Impact of graft type on outcome in pediatric liver transplantation: a report From Studies of Pediatric Liver Transplantation (SPLIT). Ann Surg 2007; 246:301–310.
Spada M, Angelico R, Grimaldi C, et al. The new horizon of split-liver transplantation: ex situ liver splitting during hypothermic oxygenated machine perfusion. Liver Transpl 2020; 26:1363–1367.
Rossignol G, Muller X, Mohkam K, et al. Full left/full right liver graft ex situ split during hypothermic oxygenated perfusion. Pediatr Transplant 2022; 26:e14284.
Rossignol G, Muller X, Hervieu V, et al. Liver transplantation of partial grafts after ex situ splitting during hypothermic oxygenated perfusion-the HOPE-Split pilot study. Liver Transpl 2022; 28:1576–1587.
Ravikumar R, Jassem W, Mergental H, et al. Liver transplantation after ex vivo normothermic machine preservation: a phase 1 (first-in-man) clinical trial. Am J Transplant 2016; 16:1779–1787.
van Beekum CJ, Vilz TO, Glowka TR, et al. Normothermic Machine Perfusion (NMP) of the liver - current status and future perspectives. Ann Transplant 2021; 26:e931664.
Limited O: The OrganOx metra® – robust, fully automated and easy-to-use. 2022.
Nasralla D, Coussios CC, Mergental H, et al. Consortium for Organ Preservation in Europe. A randomized trial of normothermic preservation in liver transplantation. Nature 2018; 557:50–56.
Jayant K, Reccia I, Virdis F, Shapiro AMJ. The role of normothermic perfusion in liver transplantation (TRaNsIT Study): a systematic review of preliminary studies. HPB Surg 2018; 2018:6360423.
Ramirez-Del Val A, Guarrera J, Porte RJ, et al. Eras4Olt.org Working Group: Kyra Fraser LUKBLLUKCNSFCAUSAJ-MP: does machine perfusion improve immediate and short-term outcomes by enhancing graft function and recipient recovery after liver transplantation? A systematic review of the literature, meta-analysis and expert panel recommendations. Clin Transplant 2022; 36:e14638.
Bral M, Gala-Lopez B, Bigam D, et al. Preliminary single-center canadian experience of human normothermic ex vivo liver perfusion: results of a clinical trial. Am J Transplant 2017; 17:1071–1080.
Ceresa CDL, Nasralla D, Watson CJE, et al. Transient cold storage prior to normothermic liver perfusion may facilitate adoption of a novel technology. Liver Transpl 2019; 25:1503–1513.
Bral M, Dajani K, Leon Izquierdo D, et al. A back-to-base experience of human normothermic ex situ liver perfusion: does the chill kill? Liver Transpl 2019; 25:848–858.
Patrono D, De Carlis R, Gambella A, et al. Viability assessment and transplantation of fatty liver grafts using end-ischemic normothermic machine perfusion. Liver Transpl 2022; doi: 10.1002/lt.26574. [Online ahead of print].
doi: 10.1002/lt.26574.
Hann A, Lembach H, Nutu A, et al. Outcomes of normothermic machine perfusion of liver grafts in repeat liver transplantation (NAPLES initiative). Br J Surg 2022; 109:372–380.
Reiling J, Butler N, Simpson A, et al. Assessment and transplantation of orphan donor livers: a back-to-base approach to normothermic machine perfusion. Liver Transpl 2020; 26:1618–1628.
MacConmara M, Hanish SI, Hwang CS, et al. Making every liver count: increased transplant yield of donor livers through normothermic machine perfusion. Ann Surg 2020; 272:397–401.
Dingfelder J, Rauter L, Berlakovich GA, Kollmann D. Biliary viability assessment and treatment options of biliary injury during normothermic liver perfusion-a systematic review. Transpl Int 2022; 35:10398.
Melandro F, De Carlis R, Torri F, et al. Viability criteria during liver ex-situ normothermic and hypothermic perfusion. Medicina (Kaunas) 2022; 58:1434.
Eshmuminov D, Becker D, Bautista Borrego L, et al. An integrated perfusion machine preserves injured human livers for 1 week. Nat Biotechnol 2020; 38:189–198.
Clavien PA, Dutkowski P, Mueller M, et al. Transplantation of a human liver following 3 days of ex situ normothermic preservation. Nat Biotechnol 2022; 40:1610–1616.
Vogel T, Brockmann JG, Quaglia A, et al. The 24-h normothermic machine perfusion of discarded human liver grafts. Liver Transpl 2017; 23:207–220.
Markmann JF, Abouljoud MS, Ghobrial RM, et al. Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant: the OCS Liver PROTECT Randomized Clinical Trial. JAMA Surg 2022; 157:189–198.
Boteon YL, Laing RW, Schlegel A, et al. Combined hypothermic and normothermic machine perfusion improves functional recovery of extended criteria donor livers. Liver Transpl 2018; 24:1699–1715.
van Leeuwen OB, de Vries Y, Fujiyoshi M, et al. Transplantation of high-risk donor livers after ex situ resuscitation and assessment using combined hypo- and normothermic machine perfusion: a prospective clinical trial. Ann Surg 2019; 270:906–914.
de Vries Y, Matton APM, Nijsten MWN, et al. Pretransplant sequential hypo- and normothermic machine perfusion of suboptimal livers donated after circulatory death using a hemoglobin-based oxygen carrier perfusion solution. Am J Transplant 2019; 19:1202–1211.
van Leeuwen OB, Bodewes SB, Lantinga VA, et al. Sequential hypothermic and normothermic machine perfusion enables safe transplantation of high-risk donor livers. Am J Transplant 2022; 22:1658–1670.
Boteon A, Schlegel A, Carvalho MF, Boteon YL. Hypothermic oxygenated machine perfusion as a tool to facilitate liver transplantation in the acute-on-chronic liver failure scenario. Liver Transpl 2022; 28:1678–1680.