COVID-19 and atrial fibrillation: Intercepting lines.
COVID-19
COVID-19 drugs
atrial fibrillation
atrial remodeling
inflammation
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2023
2023
Historique:
received:
08
11
2022
accepted:
09
01
2023
entrez:
9
2
2023
pubmed:
10
2
2023
medline:
10
2
2023
Statut:
epublish
Résumé
Almost 20% of COVID-19 patients have a history of atrial fibrillation (AF), but also a new-onset AF represents a frequent complication in COVID-19. Clinical evidence demonstrates that COVID-19, by promoting the evolution of a prothrombotic state, increases the susceptibility to arrhythmic events during the infective stages and presumably during post-recovery. AF itself is the most frequent form of arrhythmia and is associated with substantial morbidity and mortality. One of the molecular factors involved in COVID-19-related AF episodes is the angiotensin-converting enzyme (ACE) 2 availability. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses ACE2 to enter and infect multiple cells. Atrial ACE2 internalization after binding to SARS-CoV-2 results in a raise of angiotensin (Ang) II, and in a suppression of cardioprotective Ang(1-7) formation, and thereby promoting cardiac hypertrophy, fibrosis and oxidative stress. Furthermore, several pharmacological agents used in COVID-19 patients may have a higher risk of inducing electrophysiological changes and cardiac dysfunction. Azithromycin, lopinavir/ritonavir, ibrutinib, and remdesivir, used in the treatment of COVID-19, may predispose to an increased risk of cardiac arrhythmia. In this review, putative mechanisms involved in COVID-19-related AF episodes and the cardiovascular safety profile of drugs used for the treatment of COVID-19 are summarized.
Identifiants
pubmed: 36755799
doi: 10.3389/fcvm.2023.1093053
pmc: PMC9899905
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1093053Informations de copyright
Copyright © 2023 Donniacuo, De Angelis, Rafaniello, Cianflone, Paolisso, Torella, Sibilio, Paolisso, Castaldo, Urbanek, Rossi, Berrino and Cappetta.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Kardiol Pol. 2022;80(1):90-92
pubmed: 34845713
Circ Arrhythm Electrophysiol. 2016 May;9(5):
pubmed: 27162031
Front Med. 2020 Apr;14(2):185-192
pubmed: 32170560
JAMA. 2020 Apr 7;323(13):1239-1242
pubmed: 32091533
Cent Eur J Immunol. 2022;47(1):95-101
pubmed: 35600151
Front Pharmacol. 2021 Apr 20;12:667254
pubmed: 33959029
Clin Microbiol Rev. 2020 Oct 14;34(1):
pubmed: 33055231
J Cardiothorac Vasc Anesth. 2021 Dec;35(12):3789-3796
pubmed: 32888796
Cureus. 2020 May 11;12(5):e8054
pubmed: 32537272
Life Sci. 2022 Jun 15;299:120529
pubmed: 35385795
J Interv Card Electrophysiol. 2020 Nov;59(2):329-336
pubmed: 32494896
Int J Mol Sci. 2021 Jul 31;22(15):
pubmed: 34361021
Sci Total Environ. 2022 Feb 20;808:152072
pubmed: 34863742
J Basic Clin Physiol Pharmacol. 2022 May 03;:
pubmed: 35503307
Nutrients. 2022 Mar 09;14(6):
pubmed: 35334812
J Cardiovasc Electrophysiol. 2020 May;31(5):1003-1008
pubmed: 32270559
Minerva Endocrinol (Torino). 2022 Sep;47(3):270-278
pubmed: 35266671
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
Curr Rev Clin Exp Pharmacol. 2021;16(4):306-317
pubmed: 33357185
Cardiol Res Pract. 2020 Apr 13;2020:1358098
pubmed: 32351730
Clin Sci (Lond). 2021 Dec 22;135(24):2667-2689
pubmed: 34807265
Heart Rhythm. 2020 Sep;17(9):1456-1462
pubmed: 32244059
Int J Med Sci. 2022 Oct 24;19(13):1903-1911
pubmed: 36438922
J Am Coll Cardiol. 2019 Oct 1;74(13):1667-1678
pubmed: 31558250
Lancet. 2020 Mar 28;395(10229):1054-1062
pubmed: 32171076
J Med Virol. 2020 Oct;92(10):1875-1883
pubmed: 32441789
Br J Pharmacol. 2022 May;179(10):2128-2148
pubmed: 33960398
Intern Emerg Med. 2022 Sep;17(6):1571-1574
pubmed: 35704169
Sci Rep. 2022 Jan 24;12(1):1212
pubmed: 35075175
Int J Cardiol. 2021 Feb 1;324:255-260
pubmed: 33075384
Int J Cardiol Heart Vasc. 2020 Oct;30:100631
pubmed: 32904969
Blood. 2020 May 21;135(21):1912-1915
pubmed: 32302379
J Exp Med. 2021 Mar 1;218(3):
pubmed: 33231615
Nat Rev Cardiol. 2020 Jun;17(6):378
pubmed: 32332868
Molecules. 2022 Mar 22;27(7):
pubmed: 35408447
Circulation. 2001 Dec 11;104(24):2886-91
pubmed: 11739301
Front Physiol. 2018 Oct 09;9:1383
pubmed: 30356673
JAMA. 1994 Mar 16;271(11):840-4
pubmed: 8114238
J Arrhythm. 2020 Dec 11;37(1):231-237
pubmed: 33664908
Front Cardiovasc Med. 2022 Mar 21;9:862571
pubmed: 35387441
Microorganisms. 2021 Aug 09;9(8):
pubmed: 34442770
Semin Immunol. 2021 Jun;55:101508
pubmed: 34728121
Epidemiol Health. 2020;42:e2020013
pubmed: 32192278
Eur Cardiol. 2020 Nov 09;15:e66
pubmed: 33294034
Cells. 2021 Jun 08;10(6):
pubmed: 34201214
J Infect. 2020 Sep;81(3):e41-e43
pubmed: 32603675
Inflammation. 2021 Feb;44(1):13-34
pubmed: 33029758
Front Cardiovasc Med. 2021 Jul 20;8:662914
pubmed: 34355025
J Virol. 2016 Sep 12;90(19):8924-33
pubmed: 27466418
Int J Mol Sci. 2022 Apr 07;23(8):
pubmed: 35456912
Thromb Res. 2021 Feb;198:19-22
pubmed: 33249247
Eur J Neurol. 2022 Jul;29(7):1963-1971
pubmed: 35344638
J Clin Virol. 2020 Jun;127:104370
pubmed: 32344321
Top Curr Chem. 2015;367:1-28
pubmed: 23873408
Br J Haematol. 2020 Jul;190(2):e73-e76
pubmed: 32433778
Circulation. 2006 Jul 11;114(2):119-25
pubmed: 16818816
Am J Med Sci. 2022 Apr;363(4):281-287
pubmed: 35093394
Inform Med Unlocked. 2021;23:100541
pubmed: 33649734
Cardiovasc Drugs Ther. 2021 Apr;35(2):231-247
pubmed: 33404925
Diagn Pathol. 2020 Aug 14;15(1):103
pubmed: 32799894
Br J Pharmacol. 2020 Nov;177(21):4813-4824
pubmed: 32329520
Circulation. 2004 Jan 27;109(3):363-8
pubmed: 14732752
JACC Clin Electrophysiol. 2021 Sep;7(9):1120-1130
pubmed: 33895107
Transpl Immunol. 2022 Feb;70:101495
pubmed: 34774738
Sci Rep. 2022 Feb 3;12(1):1856
pubmed: 35115644
J Med Virol. 2021 Oct;93(10):5724-5725
pubmed: 34232520
Clin Infect Dis. 2020 Nov 19;71(16):2089-2098
pubmed: 32361738
Aging Dis. 2022 Feb 1;13(1):144-156
pubmed: 35111367
Int J Mol Sci. 2018 Mar 25;19(4):
pubmed: 29587379
N Engl J Med. 2021 Aug 26;385(9):777-789
pubmed: 34351722
Eur Heart J. 2021 Feb 1;42(5):373-498
pubmed: 32860505
JAMA Cardiol. 2020 Jul 1;5(7):802-810
pubmed: 32211816
J Card Fail. 2011 Jan;17(1):82-90
pubmed: 21187267
J Physiol. 2021 Sep;599(18):4269-4285
pubmed: 34174086
Auton Neurosci. 2022 Jan;237:102903
pubmed: 34894589
Atherosclerosis. 2020 Dec;314:58-62
pubmed: 33161318
Biomed Pharmacother. 2022 Jan;145:112420
pubmed: 34801852
Clin Transl Sci. 2021 Jan;14(1):20-28
pubmed: 32888379
Front Cell Infect Microbiol. 2020 Jun 05;10:317
pubmed: 32582574
Eur Heart J. 2020 May 14;41(19):1821-1829
pubmed: 32383763
Sci Rep. 2022 Mar 8;12(1):4058
pubmed: 35260724
Circ Res. 2020 Jun 19;127(1):21-33
pubmed: 32716721
JACC Clin Electrophysiol. 2020 Sep;6(9):1189-1190
pubmed: 32972558
Signal Transduct Target Ther. 2020 Dec 4;5(1):283
pubmed: 33277466
Cardiovasc Res. 2017 Nov 01;113(13):1688-1699
pubmed: 29016724
Heart Rhythm. 2020 Sep;17(9):1439-1444
pubmed: 32585191
Int J Mol Sci. 2022 Mar 13;23(6):
pubmed: 35328506
J Mol Cell Cardiol. 2018 Jan;114:253-263
pubmed: 29191788
J Cardiovasc Pharmacol. 2020 Aug;76(2):138-145
pubmed: 32453074
Nat Genet. 2021 Feb;53(2):205-214
pubmed: 33432184
Heart. 2022 May 25;108(12):902-904
pubmed: 35314451
Am J Transl Res. 2022 Jun 15;14(6):4097-4103
pubmed: 35836904
Europace. 2012 May;14(5):623-30
pubmed: 22237583
J Thromb Haemost. 2020 Sep;18(9):2422-2424
pubmed: 32426897
N Engl J Med. 2020 Jun 11;382(24):2327-2336
pubmed: 32275812
Signal Transduct Target Ther. 2021 Dec 10;6(1):418
pubmed: 34893580
Biomolecules. 2022 Jan 05;12(1):
pubmed: 35053224
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
J Cell Mol Med. 2021 Mar;25(6):2764-2775
pubmed: 33576189
Nature. 2002 Jan 10;415(6868):198-205
pubmed: 11805843
PLoS Pathog. 2020 May 22;16(5):e1008536
pubmed: 32442210
Circulation. 2018 Nov 13;138(20):2227-2242
pubmed: 29802206
Clin Pharmacol Ther. 2021 Dec;110(6):1526-1536
pubmed: 34287842
Pharmaceuticals (Basel). 2021 Jun 25;14(7):
pubmed: 34202350
Curr Drug Metab. 2009 Jun;10(5):470-81
pubmed: 19689244
Cells. 2022 May 23;11(10):
pubmed: 35626754
Circ Arrhythm Electrophysiol. 2021 Feb;14(2):e009375
pubmed: 33591815
Cureus. 2022 Apr 7;14(4):e23912
pubmed: 35530910