The Long Noncoding RNA Gm9866/Nuclear Factor-
Journal
Mediators of inflammation
ISSN: 1466-1861
Titre abrégé: Mediators Inflamm
Pays: United States
ID NLM: 9209001
Informations de publication
Date de publication:
2023
2023
Historique:
received:
29
12
2022
revised:
17
01
2023
accepted:
18
01
2023
entrez:
9
2
2023
pubmed:
10
2
2023
medline:
11
2
2023
Statut:
epublish
Résumé
Macrophages are a type of immune cells with high levels of plasticity and heterogeneity. They can polarize into M1 or M2 functional phenotypes. These two phenotypes exhibit a dynamic balance during polarization-related diseases and play opposing roles. Long noncoding RNAs (lncRNAs) play an important role in biological processes such as cell proliferation, death, and differentiation; however, how long noncoding RNAs affect the cellular functionality of macrophages remains to be studied. Long noncoding RNA Gm9866 was found to be closely related to macrophage polarization through bioinformatics analysis. In this study, by conducting real-time polymerase chain reaction analysis, it was observed that long noncoding RNA Gm9866 expression significantly increased after treatment with interleukin-4 but significantly decreased after treatment with lipopolysaccharide. Fluorescence
Identifiants
pubmed: 36756088
doi: 10.1155/2023/9991916
pmc: PMC9899594
doi:
Substances chimiques
Mannose Receptor
0
NF-kappa B
0
RNA, Long Noncoding
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
9991916Informations de copyright
Copyright © 2023 Xiaomin Liao et al.
Déclaration de conflit d'intérêts
No potential conflict of interest was reported by the authors.
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