α-tocopherol as a selective modulator of toxicogenic damage induced by antineoplastic agents cyclophosphamide and doxorubicin.

Humans alpha-Tocopherol / pharmacology Saccharomyces cerevisiae Leukocytes, Mononuclear Antineoplastic Agents / toxicity Doxorubicin / toxicity Cyclophosphamide / toxicity Vitamin E
Cancer treatment antioxidant activity chemoprotection cytotoxicity vitamin E supplementation

Journal

Journal of toxicology and environmental health. Part A
ISSN: 1528-7394
Titre abrégé: J Toxicol Environ Health A
Pays: England
ID NLM: 100960995

Informations de publication

Date de publication:
16 02 2023
Historique:
pubmed: 10 2 2023
medline: 15 2 2023
entrez: 9 2 2023
Statut: ppublish

Résumé

The aim of this study was to determine the oxidative/antioxidative effects, modulatory and selective potential of α-tocopherol (vitamin E) on antineoplastic drug-induced toxicogenetic damage. The toxicity, cytotoxicity and genotoxicity induced by antineoplastic agents cyclophosphamide (CPA) and doxorubicin (DOX) was examined utilizing as models

Identifiants

DOI: 10.1080/15287394.2023.2168224 PMID: 36756732
pubmed: 36756732
doi: 10.1080/15287394.2023.2168224
doi:

Substances chimiques

alpha-Tocopherol H4N855PNZ1
Antineoplastic Agents 0
Doxorubicin 80168379AG
Cyclophosphamide 8N3DW7272P
Vitamin E 1406-18-4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

87-102

Auteurs

Victor Alves de Oliveira (VA)

Department of Nutrition, Campus Senador Helvídio Nunes de Barros - CSHNB, Federal University of Piauí - UFPI, Picos, Brazil.
ORCID: 0000-0003-1039-7657

Andressa Naiane Rodrigues Monteiro Fernandes (ANR)

Laboratory of Research, Campus Senador Helvídio Nunes de Barros - CSHNB, Federal University of Piauí - UFPI, Picos, Brazil.

Lauana Maria Dos Santos Leal (LM)

Laboratory of Research, Campus Senador Helvídio Nunes de Barros - CSHNB, Federal University of Piauí - UFPI, Picos, Brazil.

Paloma Alves Ferreira Lima (PA)

Laboratory of Research, Campus Senador Helvídio Nunes de Barros - CSHNB, Federal University of Piauí - UFPI, Picos, Brazil.

Ana Rafaela Silva Pereira (AR)

Laboratory of Research, Campus Senador Helvídio Nunes de Barros - CSHNB, Federal University of Piauí - UFPI, Picos, Brazil.

Irislene Costa Pereira (IC)

Department of Biophysics and Physiology, Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN) Center for Health Sciences, Federal University of Piaui, Teresina, Brazil.

Helber Alves Negreiros (HA)

Laboratory of Research, Campus Senador Helvídio Nunes de Barros - CSHNB, Federal University of Piauí - UFPI, Picos, Brazil.

Joilane Alves Pereira-Freire (JA)

Department of Nutrition, Campus Senador Helvídio Nunes de Barros - CSHNB, Federal University of Piauí - UFPI, Picos, Brazil.
ORCID: 0000-0003-0596-934X

Felipe Cavalcanti Carneiro da Silva (FCC)

Laboratory of Research, Campus Senador Helvídio Nunes de Barros - CSHNB, Federal University of Piauí - UFPI, Picos, Brazil.

Ana Amélia de Carvalho Melo Cavalcante (AA)

Department of Biophysics and Physiology, Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN) Center for Health Sciences, Federal University of Piaui, Teresina, Brazil.

Francisco Leonardo Torres-Leal (FL)

Department of Biophysics and Physiology, Metabolic Diseases, Exercise and Nutrition Research Group (DOMEN) Center for Health Sciences, Federal University of Piaui, Teresina, Brazil.

Adriana Paiva Azevedo (AP)

Post-graduate program of Food and Nutrition, Federal University of Piauí - UFPI, Picos, Brazil.

João Marcelo de Castro E Sousa (JM)

Post-graduate program of Biotechnology (RENORBIO), Federal University of Piauí - UFPI, Picos, Brazil.
Department of Biochemistry and Pharmacology, Post-graduate program of Pharmaceutical sciences, Federal University of Piauí - UFPI, Picos, Brazil.
ORCID: 0000-0002-5085-1482

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › α-tocopherol as a selective modulator of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › Tocophérols › alpha-Tocophérol › α-tocopherol as a selective modulator of...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › α-tocopherol as a selective modulator of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › α-tocopherol as a selective modulator of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › α-tocopherol as a selective modulator of...
questionsmedicales.fr › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › α-tocopherol as a selective modulator of...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphoramides › Moutardes phosphoramide › Cyclophosphamide › α-tocopherol as a selective modulator of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › Vitamine E › α-tocopherol as a selective modulator of...