Recent Updates in Understanding NSAID Hypersensitivity.
Aspirin
COX-2 inhibitors
NSAID hypersensitivity
Oral provocation test
Urticaria
Journal
Current allergy and asthma reports
ISSN: 1534-6315
Titre abrégé: Curr Allergy Asthma Rep
Pays: United States
ID NLM: 101096440
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
accepted:
15
12
2022
pubmed:
10
2
2023
medline:
8
3
2023
entrez:
9
2
2023
Statut:
ppublish
Résumé
To provide a review of available literature regarding nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity with an emphasis on more recent findings. Oral provocation tests with aspirin are important for diagnosis and management in adult and pediatric populations with reported NSAID hypersensitivity. Risk of cross-reactivity to COX-2 inhibitors varies by NSAID hypersensitivity phenotype. COX-2 inhibitors are tolerated in aspirin-exacerbated respiratory disease. Reported NSAID allergy is associated with a higher risk of a substance use disorder. Effective treatment of underlying chronic spontaneous urticaria can allow tolerance of NSAIDs in NSAID-exacerbated cutaneous disease. The pathophysiology, cross-reactivity, and appropriate diagnostic evaluation differ between the 5 distinct NSAID hypersensitivity phenotypes. Further research into the pathophysiology of NSAID hypersensitivity in patients with and without underlying disease is needed.
Identifiants
pubmed: 36757490
doi: 10.1007/s11882-023-01064-3
pii: 10.1007/s11882-023-01064-3
doi:
Substances chimiques
Cyclooxygenase 2 Inhibitors
0
Anti-Inflammatory Agents, Non-Steroidal
0
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
181-188Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.