Human pancreatic islet microRNAs implicated in diabetes and related traits by large-scale genetic analysis.

Humans MicroRNAs / metabolism Diabetes Mellitus, Type 2 / genetics Glycated Hemoglobin Islets of Langerhans / metabolism Quantitative Trait Loci / genetics
diabetes eQTL microRNA pancreatic islets

Journal

Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876

Informations de publication

Date de publication:
14 02 2023
Historique:
entrez: 9 2 2023
pubmed: 10 2 2023
medline: 14 2 2023
Statut: ppublish

Résumé

Genetic studies have identified ≥240 loci associated with the risk of type 2 diabetes (T2D), yet most of these loci lie in non-coding regions, masking the underlying molecular mechanisms. Recent studies investigating mRNA expression in human pancreatic islets have yielded important insights into the molecular drivers of normal islet function and T2D pathophysiology. However, similar studies investigating microRNA (miRNA) expression remain limited. Here, we present data from 63 individuals, the largest sequencing-based analysis of miRNA expression in human islets to date. We characterized the genetic regulation of miRNA expression by decomposing the expression of highly heritable miRNAs into

Identifiants

DOI: 10.1073/pnas.2206797120 PMID: 36757889 PMC: PMC9963967
pubmed: 36757889
doi: 10.1073/pnas.2206797120
pmc: PMC9963967
doi:

Substances chimiques

MicroRNAs 0
Glycated Hemoglobin 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2206797120

Subventions

Organisme : Intramural NIH HHS
ID : ZIA HG000024
Pays : United States

Commentaires et corrections

Type : ErratumIn

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Auteurs

Henry J Taylor (HJ)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.
British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB2 0BB, UK.
Heart and Lung Research Institute, University of Cambridge, Cambridge CB2 0BB, UK.
ORCID: 0000-0003-2088-5240

Yu-Han Hung (YH)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Narisu Narisu (N)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.

Michael R Erdos (MR)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.

Matthew Kanke (M)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Tingfen Yan (T)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.

Caleb M Grenko (CM)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.

Amy J Swift (AJ)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.

Lori L Bonnycastle (LL)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.

Praveen Sethupathy (P)

Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853.

Francis S Collins (FS)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.
ORCID: 0000-0002-1023-7410

D Leland Taylor (DL)

Center for Precision Health Research, National Human Genome Research Institute, NIH, Bethesda, MD 20892.
ORCID: 0000-0001-6498-6970

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questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Human pancreatic islet microRNAs implicated in...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Human pancreatic islet microRNAs implicated in...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète de type 2 › Human pancreatic islet microRNAs implicated in...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Produits terminaux de glycation avancée › Protéines glyquées › Protéine glycosylée sérique › Hémoglobine glycosylée › Human pancreatic islet microRNAs implicated in...
questionsmedicales.fr › Système endocrine › Glandes endocrines › Ilots pancréatiques › Human pancreatic islet microRNAs implicated in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Human pancreatic islet microRNAs implicated in...