Altered global signal topography in Alzheimer's disease.
Alzheimer's disease
Functional network
Global signal
Transcriptomics
Journal
EBioMedicine
ISSN: 2352-3964
Titre abrégé: EBioMedicine
Pays: Netherlands
ID NLM: 101647039
Informations de publication
Date de publication:
Mar 2023
Mar 2023
Historique:
received:
07
06
2022
revised:
31
12
2022
accepted:
17
01
2023
pubmed:
10
2
2023
medline:
15
3
2023
entrez:
9
2
2023
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a neurodegenerative disease associated with widespread disruptions in intrinsic local specialization and global integration in the functional system of the brain. These changes in integration may further disrupt the global signal (GS) distribution, which might represent the local relative contribution to global activity in functional magnetic resonance imaging (fMRI). fMRI scans from a discovery dataset (n = 809) and a validated dataset (n = 542) were used in the analysis. We investigated the alteration of GS topography using the GS correlation (GSCORR) in patients with mild cognitive impairment (MCI) and AD. The association between GS alterations and functional network properties was also investigated based on network theory. The underlying mechanism of GSCORR alterations was elucidated using imaging-transcriptomics. Significantly increased GS topography in the frontal lobe and decreased GS topography in the hippocampus, cingulate gyrus, caudate, and middle temporal gyrus were observed in patients with AD (P Our findings revealed significant changes in GS topography and its molecular basis, confirming the informative role of GS in AD and further contributing to the understanding of the relationship between global and local neuronal activities in patients with AD. Beijing Natural Science Funds for Distinguished Young Scholars, China; Fundamental Research Funds for the Central Universities, China; National Natural Science Foundation, China.
Sections du résumé
BACKGROUND
BACKGROUND
Alzheimer's disease (AD) is a neurodegenerative disease associated with widespread disruptions in intrinsic local specialization and global integration in the functional system of the brain. These changes in integration may further disrupt the global signal (GS) distribution, which might represent the local relative contribution to global activity in functional magnetic resonance imaging (fMRI).
METHODS
METHODS
fMRI scans from a discovery dataset (n = 809) and a validated dataset (n = 542) were used in the analysis. We investigated the alteration of GS topography using the GS correlation (GSCORR) in patients with mild cognitive impairment (MCI) and AD. The association between GS alterations and functional network properties was also investigated based on network theory. The underlying mechanism of GSCORR alterations was elucidated using imaging-transcriptomics.
FINDINGS
RESULTS
Significantly increased GS topography in the frontal lobe and decreased GS topography in the hippocampus, cingulate gyrus, caudate, and middle temporal gyrus were observed in patients with AD (P
INTERPRETATION
CONCLUSIONS
Our findings revealed significant changes in GS topography and its molecular basis, confirming the informative role of GS in AD and further contributing to the understanding of the relationship between global and local neuronal activities in patients with AD.
FUNDING
BACKGROUND
Beijing Natural Science Funds for Distinguished Young Scholars, China; Fundamental Research Funds for the Central Universities, China; National Natural Science Foundation, China.
Identifiants
pubmed: 36758481
pii: S2352-3964(23)00020-8
doi: 10.1016/j.ebiom.2023.104455
pmc: PMC9941064
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104455Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests PW reports grants from the National Natural Science Foundation of China, during the conduct of the study; DW reports grants from the National Natural Science Foundation of China, during the conduct of the study; YH reports grants from the National Natural Science Foundation of China, during the conduct of the study; XZ reports grants from National Natural Science Foundation of China, during the conduct of the study; YL reports grants from Ministry of Education of the People's Republic of China, grants from Beijing Natural Science Funds, grants from National Natural Science Foundation of China, during the conduct of the study. The remaining authors reported no relevant conflicts.