Plant production of a virus-like particle-based vaccine candidate against porcine reproductive and respiratory syndrome.
PRRS (porcine reproductive and respiratory syndrome virus)
PRRSV
plant molecular farming
subunit vaccine
tobacco mosaic virus
virus-like particle
Journal
Frontiers in plant science
ISSN: 1664-462X
Titre abrégé: Front Plant Sci
Pays: Switzerland
ID NLM: 101568200
Informations de publication
Date de publication:
2023
2023
Historique:
received:
14
09
2022
accepted:
10
01
2023
entrez:
10
2
2023
pubmed:
11
2
2023
medline:
11
2
2023
Statut:
epublish
Résumé
Porcine reproductive and respiratory syndrome (PRRS) is a disease leading to spontaneous abortions and stillbirths in sows and lowered life quality and expectancy in growing pigs. PRRS is prevalent worldwide and has significant economic impacts to swine industries around the globe. Co-expression of the two most abundant proteins in the viral envelope, the matrix protein (M) and glycosylated protein 5 (GP5), can produce a neutralizing immune response for the virus providing a potentially effective subunit vaccine against the disease, but these proteins are difficult to express. The goal of this research was to display antigenic portions of the M and GP5 proteins on the surface of tobacco mosaic virus-like particles. A modified tobacco mosaic virus coat protein (TMVc) was transiently expressed in
Identifiants
pubmed: 36760639
doi: 10.3389/fpls.2023.1044675
pmc: PMC9902946
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1044675Informations de copyright
Copyright © 2023 VanderBurgt, Harper, Garnham, Kohalmi and Menassa.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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