Pyruvate Dehydrogenase Complex and Glucose Oxidation as a Therapeutic Target in Diabetic Heart Disease.
Cardiac energetics
Diabetic cardiomyopathies
Diabetic heart disease
Diastolic dysfunction
Glucose oxidation
Pyruvate dehydrogenase
Journal
Journal of lipid and atherosclerosis
ISSN: 2287-2892
Titre abrégé: J Lipid Atheroscler
Pays: Korea (South)
ID NLM: 101610890
Informations de publication
Date de publication:
Jan 2023
Jan 2023
Historique:
received:
27
07
2022
revised:
01
09
2022
accepted:
07
09
2022
entrez:
10
2
2023
pubmed:
11
2
2023
medline:
11
2
2023
Statut:
ppublish
Résumé
Diabetic cardiomyopathy was originally described as the presence of ventricular dysfunction in the absence of coronary artery disease and/or hypertension. It is characterized by diastolic dysfunction and is more prevalent in people with diabetes than originally realized, leading to the suggestion in the field that it simply be referred to as diabetic heart disease. While there are currently no approved therapies for diabetic heart disease, a multitude of studies clearly demonstrate that it is characterized by several disturbances in myocardial energy metabolism. One of the most prominent changes in myocardial energy metabolism in diabetes is a robust impairment in glucose oxidation. Herein we will describe the mechanisms responsible for the diabetes-induced decline in myocardial glucose oxidation, and the pharmacological approaches that have been pursued to correct this metabolic disorder. With surmounting evidence that stimulating myocardial glucose oxidation can alleviate diastolic dysfunction and other pathologies associated with diabetic heart disease, this may also represent a novel strategy for decreasing the prevalence of heart failure with preserved ejection fraction in the diabetic population.
Identifiants
pubmed: 36761067
doi: 10.12997/jla.2023.12.1.47
pmc: PMC9884548
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
47-57Informations de copyright
Copyright © 2023 The Korean Society of Lipid and Atherosclerosis.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no conflicts of interest to declare.
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