Predictors of weight loss in patients with obesity treated with a Very Low-Calorie Ketogenic Diet.
body composition
fibroblast growth factor 21
insulin resistance
low carbohydrate diet (LCD)
protein sparing modified fasting
very low energy diet
Journal
Frontiers in nutrition
ISSN: 2296-861X
Titre abrégé: Front Nutr
Pays: Switzerland
ID NLM: 101642264
Informations de publication
Date de publication:
2023
2023
Historique:
received:
30
09
2022
accepted:
05
01
2023
entrez:
10
2
2023
pubmed:
11
2
2023
medline:
11
2
2023
Statut:
epublish
Résumé
The Very Low-Calorie Ketogenic Diet (VLCKD) has emerged as a safe and effective intervention for the management of metabolic disease. Studies examining weight loss predictors are scarce and none has investigated such factors upon VLCKD treatment. Among the molecules involved in energy homeostasis and, more specifically, in metabolic changes induced by ketogenic diets, Fibroblast Growth Factor 21 (FGF21) is a hepatokine with physiology that is still unclear. We evaluated the impact of a VLCKD on weight loss and metabolic parameters and assessed weight loss predictors, including FGF21. VLCKD is a severely restricted diet (<800 Kcal/die), characterized by a very low carbohydrate intake (<50 g/day), 1.2-1.5 g protein/kg of ideal body weight and 15-30 g of fat/day. We treated 34 patients with obesity with a VLCKD for 45 days. Anthropometric parameters, body composition, and blood and urine chemistry were measured before and after treatment. We found a significant improvement in body weight and composition and most metabolic parameters. Circulating FGF21 decreased significantly after the VLCKD [194.0 (137.6-284.6) to 167.8 (90.9-281.5) VLCKD is a safe and effective treatment for obesity and obesity related metabolic derangements. Men with central obesity and lower circulating FGF21 may benefit more than others in terms of weight loss obtained following this diet. Further studies investigating whether this is specific to this diet or to any caloric restriction are warranted.
Identifiants
pubmed: 36761216
doi: 10.3389/fnut.2023.1058364
pmc: PMC9905243
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1058364Informations de copyright
Copyright © 2023 Ernesti, Baratta, Watanabe, Risi, Camajani, Persichetti, Tuccinardi, Mariani, Lubrano, Genco, Spera, Gnessi and Basciani.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Int J Obes (Lond). 2020 Nov;44(11):2291-2302
pubmed: 32327722
BMC Endocr Disord. 2021 Feb 27;21(1):32
pubmed: 33639916
Endocrine. 2020 Jan;67(1):95-108
pubmed: 31728756
Diabetes. 2010 Nov;59(11):2781-9
pubmed: 20682689
J Clin Endocrinol Metab. 2020 Sep 1;105(9):
pubmed: 32484877
Exp Clin Endocrinol Diabetes. 2008 Jan;116(1):65-8
pubmed: 17926232
Gastroenterology. 2010 Aug;139(2):456-63
pubmed: 20451522
Obes Rev. 2021 Mar;22(3):e13148
pubmed: 33200547
Nutrients. 2020 Jul 18;12(7):
pubmed: 32708435
Nutrition. 2015 Jan;31(1):1-13
pubmed: 25287761
Behav Sci (Basel). 2017 Jul 11;7(3):
pubmed: 28696389
Nutrients. 2020 Jan 27;12(2):
pubmed: 32012661
PLoS One. 2016 Nov 10;11(11):e0164351
pubmed: 27832059
Int J Obes (Lond). 2020 Dec;44(12):2436-2443
pubmed: 32398753
Gastroenterology. 2021 May;160(6):2029-2042.e16
pubmed: 33482223
Front Psychol. 2015 Feb 02;6:27
pubmed: 25698989
J Gastrointest Surg. 2015 Oct;19(10):1758-62
pubmed: 26268956
J Diabetes Res. 2019 Aug 14;2019:8681959
pubmed: 31485454
Nutrients. 2020 Sep 09;12(9):
pubmed: 32916989
PLoS One. 2018 Aug 28;13(8):e0202683
pubmed: 30153310
Sci Immunol. 2019 Nov 15;4(41):
pubmed: 31732517
Mol Metab. 2017 Nov;6(11):1395-1406
pubmed: 29107287
Front Endocrinol (Lausanne). 2021 Nov 17;12:742873
pubmed: 34867786
Vaccines (Basel). 2022 Jan 05;10(1):
pubmed: 35062740
Mol Metab. 2014 Oct 08;4(1):51-7
pubmed: 25685689
Endocr Res. 2021 Feb;46(1):20-27
pubmed: 33074729
Neurology. 2016 Nov 29;87(22):2290-2299
pubmed: 27794108
Eur J Clin Nutr. 2017 Mar;71(3):353-357
pubmed: 27966570
Diabetes. 2010 Mar;59(3):627-33
pubmed: 20028945
Diabetes. 2014 Dec;63(12):4057-63
pubmed: 25008183
Drug Discov Ther. 2015 Dec;9(6):380-5
pubmed: 26781921
Nutrients. 2022 Jan 15;14(2):
pubmed: 35057554
Nutrition. 2020 Apr;72:110667
pubmed: 31962189
Nat Rev Endocrinol. 2020 Nov;16(11):654-667
pubmed: 32764725
Nat Rev Mol Cell Biol. 2021 Nov;22(11):751-771
pubmed: 34285405
J Clin Endocrinol Metab. 2009 Sep;94(9):3594-601
pubmed: 19531592
Int J Obes (Lond). 2017 Oct;41(10):1570-1578
pubmed: 28588304
Obes Rev. 2015 Jan;16(1):64-76
pubmed: 25402637
Eat Weight Disord. 2021 Apr;26(3):771-778
pubmed: 32451949
Front Endocrinol (Lausanne). 2019 Jun 05;10:348
pubmed: 31231311
Nat Metab. 2021 Mar;3(3):309-317
pubmed: 33758421
Ann Med. 1995 Aug;27(4):435-8
pubmed: 8519504
J Clin Endocrinol Metab. 2017 Oct 1;102(10):3806-3813
pubmed: 28938434
J Transl Med. 2019 Oct 29;17(1):356
pubmed: 31665015
Eat Weight Disord. 2021 Oct;26(7):2097-2107
pubmed: 33150534
Diabetes Care. 2019 May;42(5):731-754
pubmed: 31000505
Sci Rep. 2021 Jul 28;11(1):15392
pubmed: 34321567
Curr Nutr Rep. 2018 Sep;7(3):97-106
pubmed: 30128963
BMJ Nutr Prev Health. 2020 Dec 12;3(2):363-373
pubmed: 33521546
Cell. 2020 Jun 11;181(6):1263-1275.e16
pubmed: 32437658
Cell Metab. 2007 Jun;5(6):426-37
pubmed: 17550778
Curr Sports Med Rep. 2020 Jul;19(7):251-259
pubmed: 32692060
Annu Rev Physiol. 2016;78:223-41
pubmed: 26654352
Obes Rev. 2020 Aug;21(8):e13024
pubmed: 32207237
Obes Rev. 2020 Oct;21(10):e13053
pubmed: 32648647
Obes Surg. 2021 Dec;31(12):5383-5390
pubmed: 34558025
Annu Rev Nutr. 2018 Aug 21;38:173-196
pubmed: 29727594
Mol Metab. 2016 Nov 16;6(1):22-29
pubmed: 28123934
Eur J Clin Invest. 2010 Oct;40(10):887-92
pubmed: 20624171
J Endocrinol Invest. 2019 Nov;42(11):1365-1386
pubmed: 31111407
Circulation. 2005 Oct 25;112(17):2735-52
pubmed: 16157765
Cell Rep Med. 2021 Sep 03;2(9):100387
pubmed: 34622228
Endocrine. 2015 Apr;48(3):863-70
pubmed: 25063307
Rev Endocr Metab Disord. 2020 Mar;21(1):5-16
pubmed: 31705259
Obes Facts. 2021;14(2):222-245
pubmed: 33882506
Lipids. 2008 Jan;43(1):65-77
pubmed: 18046594
Surg Obes Relat Dis. 2022 Jul;18(7):983-996
pubmed: 35668018
Cells. 2021 Sep 14;10(9):
pubmed: 34572066