Stem cell- derived extracellular vesicles as new tools in regenerative medicine - Immunomodulatory role and future perspectives.
extracellular vesicles
immunomodulation
inflammation
paracrine activity
regenerative medicine
stem cells
tissue injury
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
09
12
2022
accepted:
11
01
2023
entrez:
10
2
2023
pubmed:
11
2
2023
medline:
14
2
2023
Statut:
epublish
Résumé
In the last few decades, the practical use of stem cells (SCs) in the clinic has attracted significant attention in the regenerative medicine due to the ability of these cells to proliferate and differentiate into other cell types. However, recent findings have demonstrated that the therapeutic capacity of SCs may also be mediated by their ability to secrete biologically active factors, including extracellular vesicles (EVs). Such submicron circular membrane-enveloped vesicles may be released from the cell surface and harbour bioactive cargo in the form of proteins, lipids, mRNA, miRNA, and other regulatory factors. Notably, growing evidence has indicated that EVs may transfer their bioactive content into recipient cells and greatly modulate their functional fate. Thus, they have been recently envisioned as a new class of paracrine factors in cell-to-cell communication. Importantly, EVs may modulate the activity of immune system, playing an important role in the regulation of inflammation, exhibiting broad spectrum of the immunomodulatory activity that promotes the transition from pro-inflammatory to pro-regenerative environment in the site of tissue injury. Consequently, growing interest is placed on attempts to utilize EVs in clinical applications of inflammatory-related dysfunctions as potential next-generation therapeutic factors, alternative to cell-based approaches. In this review we will discuss the current knowledge on the biological properties of SC-derived EVs, with special focus on their role in the regulation of inflammatory response. We will also address recent findings on the immunomodulatory and pro-regenerative activity of EVs in several disease models, including
Identifiants
pubmed: 36761725
doi: 10.3389/fimmu.2023.1120175
pmc: PMC9902918
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1120175Informations de copyright
Copyright © 2023 Karnas, Dudek and Zuba-Surma.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Stem Cells. 2006 May;24(5):1294-301
pubmed: 16410387
Stem Cell Res Ther. 2022 Jun 7;13(1):238
pubmed: 35672766
mBio. 2020 Apr 14;11(2):
pubmed: 32291301
Cell Commun Signal. 2022 Sep 19;20(1):145
pubmed: 36123730
Int J Biochem Cell Biol. 2012 Sep;44(9):1574-84
pubmed: 22728313
Oncoimmunology. 2012 Oct 1;1(7):1074-1083
pubmed: 23170255
Semin Nephrol. 2016 Nov;36(6):436-447
pubmed: 27987541
Cell Biosci. 2022 May 2;12(1):51
pubmed: 35501833
Pharmaceuticals (Basel). 2021 Aug 18;14(8):
pubmed: 34451909
J Trauma Acute Care Surg. 2018 Feb;84(2):245-256
pubmed: 29251710
Stem Cell Res Ther. 2020 Jul 1;11(1):264
pubmed: 32611371
J Interferon Cytokine Res. 2022 Jan;42(1):8-18
pubmed: 35041513
J Extracell Vesicles. 2021 Dec;10(14):e12144
pubmed: 34919343
Oxid Med Cell Longev. 2022 Apr 14;2022:4525778
pubmed: 35464764
Stem Cell Res Ther. 2018 Jan 29;9(1):17
pubmed: 29378639
Basic Res Cardiol. 2021 Mar 19;116(1):19
pubmed: 33742276
Stem Cells Dev. 2013 Mar 1;22(5):758-71
pubmed: 23034046
Biomol Ther (Seoul). 2019 Jan 31;27(1):25-33
pubmed: 29902862
Clin Sci (Lond). 2018 Jun 21;132(12):1243-1252
pubmed: 29930142
Curr Rheumatol Rev. 2018;14(2):108-116
pubmed: 28875826
Leukemia. 2012 Jun;26(6):1166-73
pubmed: 22182853
Pharmaceutics. 2020 Jul 26;12(8):
pubmed: 32722622
Stem Cell Res Ther. 2015 May 22;6:100
pubmed: 25998259
J Neuroimmune Pharmacol. 2020 Sep;15(3):520-537
pubmed: 31338754
Nucleic Acids Res. 2012 Oct;40(18):9272-85
pubmed: 22821563
J Exp Med. 2021 Aug 2;218(8):
pubmed: 34180950
Plast Reconstr Surg. 2016 Sep;138(3 Suppl):9S-17S
pubmed: 27556781
Front Cell Dev Biol. 2020 Mar 12;8:149
pubmed: 32226787
Cardiovasc Res. 2019 May 1;115(6):1041-1051
pubmed: 30388208
Nat Rev Immunol. 2014 Mar;14(3):195-208
pubmed: 24566916
J Transl Int Med. 2021 Dec 31;9(4):234-238
pubmed: 35136722
Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):2085-2092
pubmed: 28249798
J Cell Physiol. 2018 Dec;233(12):9330-9344
pubmed: 29266258
J Extracell Vesicles. 2015 Feb 09;4:26238
pubmed: 25669322
Stem Cells Transl Med. 2018 Feb;7(2):180-196
pubmed: 29297621
Gastroenterology. 2008 May;134(6):1641-54
pubmed: 18471544
Cell Death Dis. 2019 Apr 18;10(5):340
pubmed: 31000697
Traffic. 2019 Nov;20(11):815-828
pubmed: 31418976
Nano Lett. 2021 Nov 24;21(22):9410-9418
pubmed: 34730968
Nature. 2001 Apr 5;410(6829):701-5
pubmed: 11287958
Arch Pharm Res. 2017 Jan;40(1):1-12
pubmed: 27921262
J Biol Chem. 2003 May 30;278(22):20083-90
pubmed: 12639953
Transl Stroke Res. 2021 Feb;12(1):185-203
pubmed: 32361827
J Neurotrauma. 2017 Dec 15;34(24):3388-3396
pubmed: 28665182
Front Immunol. 2022 May 25;13:840550
pubmed: 35693784
J Biol Chem. 2011 Jan 7;286(1):787-96
pubmed: 20978131
Bioengineering (Basel). 2019 Sep 11;6(3):
pubmed: 31514475
Nat Cell Biol. 2009 Sep;11(9):1143-9
pubmed: 19684575
EMBO J. 2006 Jan 11;25(1):1-12
pubmed: 16052208
Stem Cell Res Ther. 2018 Jul 11;9(1):187
pubmed: 29996938
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9683-8
pubmed: 15210972
J Control Release. 2015 Jun 10;207:18-30
pubmed: 25836593
Stem Cells Transl Med. 2019 Apr;8(4):344-354
pubmed: 30618085
J Chin Med Assoc. 2013 Sep;76(9):491-6
pubmed: 23810790
Stem Cell Res Ther. 2022 Mar 28;13(1):129
pubmed: 35346367
Circulation. 2012 Nov 27;126(22):2601-11
pubmed: 23114789
Exp Mol Med. 2020 Jun;52(6):887-895
pubmed: 32541816
J Cardiovasc Transl Res. 2019 Feb;12(1):5-17
pubmed: 30456736
J Biochem. 2006 Jul;140(1):13-21
pubmed: 16877764
Gene Ther. 2008 Jan;15(2):74-81
pubmed: 17989701
Trends Cell Biol. 2009 Feb;19(2):43-51
pubmed: 19144520
Nat Rev Immunol. 2015 Sep 15;15(9):545-58
pubmed: 26250739
Stem Cells. 2020 Feb;38(2):291-300
pubmed: 31675158
Stem Cells. 2015 Sep;33(9):2748-61
pubmed: 26031404
J Extracell Vesicles. 2021 Dec;10(14):e12182
pubmed: 34953156
BMC Genomics. 2012 Aug 01;13:357
pubmed: 22849433
Trends Pharmacol Sci. 2020 Sep;41(9):653-664
pubmed: 32709406
J Am Coll Cardiol. 2018 Apr 17;71(15):1696-1706
pubmed: 29650126
J Biol Chem. 2010 Dec 17;285(51):39914-21
pubmed: 20959443
Nat Rev Cancer. 2011 Apr;11(4):268-77
pubmed: 21390058
J Biol Chem. 2011 Apr 22;286(16):14383-95
pubmed: 21300796
Curr Biol. 2009 Dec 1;19(22):1875-85
pubmed: 19896381
Viruses. 2021 Apr 18;13(4):
pubmed: 33919537
Radiol Clin North Am. 2004 Jan;42(1):1-9, v
pubmed: 15049520
J Extracell Vesicles. 2013 Dec 10;2:
pubmed: 24349659
Tissue Eng Regen Med. 2021 Aug;18(4):513-524
pubmed: 34275103
J Extracell Vesicles. 2015 Apr 20;4:26316
pubmed: 25899407
JCI Insight. 2019 Nov 1;4(21):
pubmed: 31581150
Pain. 2019 Jan;160(1):210-223
pubmed: 30188455
Semin Immunopathol. 2018 Sep;40(5):439-452
pubmed: 29616308
Stem Cell Res. 2010 May;4(3):214-22
pubmed: 20138817
J Immunol. 1999 Aug 1;163(3):1274-81
pubmed: 10415024
Stem Cells Dev. 2021 Aug 1;30(15):758-772
pubmed: 34074129
Biochem Biophys Res Commun. 2019 Mar 19;510(4):565-572
pubmed: 30739785
Front Cardiovasc Med. 2022 Jul 28;9:937995
pubmed: 35966549
Science. 2008 Feb 29;319(5867):1244-7
pubmed: 18309083
Sci Rep. 2018 Nov 5;8(1):16320
pubmed: 30397255
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):
pubmed: 28716886
Int J Nanomedicine. 2020 Aug 11;15:5911-5926
pubmed: 32848396
Cells. 2020 Apr 09;9(4):
pubmed: 32283815
Stem Cell Res Ther. 2014 Nov 10;5(6):123
pubmed: 25384638
Cells. 2019 Nov 23;8(12):
pubmed: 31771176
Nephrology (Carlton). 2015 Sep;20(9):591-600
pubmed: 25907000
Nat Chem Biol. 2017 Sep;13(9):951-955
pubmed: 28671681
Am J Respir Crit Care Med. 2018 Jan 1;197(1):104-116
pubmed: 28853608
Nat Commun. 2022 Jan 20;13(1):405
pubmed: 35058437
Stem Cell Res Ther. 2020 Jun 26;11(1):253
pubmed: 32586368
Prostate. 2014 Oct;74(14):1379-90
pubmed: 25111183
Cell Physiol Biochem. 2018;47(1):11-25
pubmed: 29763932
Int J Mol Sci. 2020 Jan 25;21(3):
pubmed: 31991836
Theranostics. 2018 Jan 1;8(1):169-184
pubmed: 29290800
Front Immunol. 2017 Jan 03;7:645
pubmed: 28096802
Stem Cells. 2019 Jun;37(6):779-790
pubmed: 30811771
J Extracell Vesicles. 2020 Aug 26;9(1):1809064
pubmed: 32944193
Adv Drug Deliv Rev. 2019 Jun;146:77-82
pubmed: 31158407
Front Cell Dev Biol. 2020 Jun 10;8:455
pubmed: 32587858
Thorax. 2019 Jan;74(1):43-50
pubmed: 30076187
Cancer Biother Radiopharm. 2007 Oct;22(5):692-703
pubmed: 17979572
J Nanobiotechnology. 2021 Sep 8;19(1):274
pubmed: 34496892
Int J Mol Sci. 2016 Aug 09;17(8):
pubmed: 27517914
Nat Biotechnol. 2011 Apr;29(4):341-5
pubmed: 21423189
J Histochem Cytochem. 2002 Jan;50(1):43-55
pubmed: 11748293
Front Neurosci. 2019 Jan 24;13:14
pubmed: 30733666
Dev Cell. 2007 May;12(5):671-82
pubmed: 17488620
Hepatology. 2018 Mar;67(3):940-954
pubmed: 29023935
J Extracell Vesicles. 2014 Dec 22;3:26913
pubmed: 25536934
Crit Care Clin. 2011 Jul;27(3):429-37
pubmed: 21742209
Curr Pharm Des. 2019;25(38):4063-4084
pubmed: 31553287
Dev Cell. 2011 Oct 18;21(4):708-21
pubmed: 21962903
Cells. 2020 Apr 01;9(4):
pubmed: 32244730
Stem Cells Dev. 2020 Jun 15;29(12):747-754
pubmed: 32380908
Clin Transl Med. 2016 Mar;5(1):7
pubmed: 26943717
J Clin Invest. 2016 Apr 1;126(4):1173-80
pubmed: 27035808
Int J Mol Med. 2018 Nov;42(5):2903-2913
pubmed: 30132508
Nat Commun. 2013;4:2980
pubmed: 24356509
Sci Rep. 2018 Feb 12;8(1):2823
pubmed: 29434302
BioDrugs. 2020 Oct;34(5):567-586
pubmed: 32754790
AAPS J. 2021 Feb 14;23(2):30
pubmed: 33586060
Stem Cells Int. 2018 Mar 4;2018:6079642
pubmed: 29686713
Front Immunol. 2018 Feb 19;9:272
pubmed: 29520273
Stem Cell Res Ther. 2013 Apr 25;4(2):34
pubmed: 23618405
J Cell Biol. 2013 Feb 18;200(4):373-83
pubmed: 23420871
Cell Commun Signal. 2021 Apr 23;19(1):47
pubmed: 33892745
Oncogene. 2020 Feb;39(7):1600-1616
pubmed: 31700155
Cell Death Dis. 2020 Apr 27;11(4):288
pubmed: 32341347
Cells. 2020 Mar 10;9(3):
pubmed: 32164386
Eur J Neurosci. 2016 Aug;44(4):2114-9
pubmed: 27177616
Leukemia. 2021 Oct;35(10):2964-2977
pubmed: 34140648
Front Cell Neurosci. 2016 May 02;10:109
pubmed: 27199663
J Lipid Res. 2010 Aug;51(8):2105-20
pubmed: 20424270
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
Clin Exp Immunol. 2022 May 12;207(3):307-317
pubmed: 35553630
J Extracell Vesicles. 2021 Jun;10(8):e12085
pubmed: 34194679
Stem Cell Rev Rep. 2022 Mar;18(3):902-932
pubmed: 34110587
Front Cell Infect Microbiol. 2021 Sep 14;11:744903
pubmed: 34595136
Stem Cell Res Ther. 2022 Jul 28;13(1):367
pubmed: 35902956
J Clin Invest. 2009 Aug;119(8):2204-17
pubmed: 19620770
Biochimie. 2007 Feb;89(2):205-12
pubmed: 17157973
J Extracell Vesicles. 2022 Feb;11(2):e12162
pubmed: 35102719
Int J Mol Sci. 2016 Feb 06;17(2):174
pubmed: 26861305
Blood. 2015 May 14;125(20):3202-12
pubmed: 25838349
Acta Biochim Biophys Sin (Shanghai). 2021 Aug 31;53(9):1166-1176
pubmed: 34254638
Adv Healthc Mater. 2022 Feb;11(4):e2101606
pubmed: 34773445
Cells. 2022 Feb 27;11(5):
pubmed: 35269448
Nephrol Dial Transplant. 2011 May;26(5):1474-83
pubmed: 21324974
Stem Cells. 2014 Jan;32(1):116-25
pubmed: 23939814
Stem Cells Transl Med. 2015 Oct;4(10):1131-43
pubmed: 26339036
Front Cell Dev Biol. 2022 Feb 03;9:752053
pubmed: 35186944
Stem Cell Res Ther. 2021 Jul 2;12(1):379
pubmed: 34215331
Lancet Infect Dis. 2020 May;20(5):533-534
pubmed: 32087114
Eur Heart J. 2015 Mar 21;36(12):751-62
pubmed: 24866210
Int J Mol Sci. 2022 Sep 10;23(18):
pubmed: 36142433
J Adv Res. 2021 Jul 08;37:221-233
pubmed: 35499059
J Control Release. 2019 Apr 10;299:149-164
pubmed: 30807806
Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H733-H744
pubmed: 29949381
Theranostics. 2018 Jan 1;8(4):906-920
pubmed: 29463990
Mol Ther. 2010 Sep;18(9):1606-14
pubmed: 20571541
J Immunol. 2007 Aug 1;179(3):1969-78
pubmed: 17641064
FASEB J. 2019 Apr;33(4):5440-5456
pubmed: 30640521
J Biol Chem. 2014 Aug 29;289(35):24488-98
pubmed: 25037226
Cardiovasc Res. 2019 Jun 1;115(7):1205-1216
pubmed: 30753344
Respir Res. 2017 Dec 21;18(1):212
pubmed: 29268735
Am J Physiol Cell Physiol. 2018 Dec 1;315(6):C885-C896
pubmed: 30404559
PLoS One. 2013 Apr 12;8(4):e61366
pubmed: 23593475
J Extracell Vesicles. 2022 Mar;11(3):e12192
pubmed: 35289114
Stem Cells Dev. 2019 Mar 15;28(6):398-409
pubmed: 30638129
J Extracell Vesicles. 2020 Feb 10;9(1):1723260
pubmed: 32128074
Eur Cell Mater. 2018 Nov 6;36:218-230
pubmed: 30398288
Cytotherapy. 2017 Apr;19(4):458-472
pubmed: 28188071
J Nanobiotechnology. 2022 Jan 20;20(1):38
pubmed: 35057811
Front Psychol. 2020 Oct 02;11:577684
pubmed: 33132986
Cell Transplant. 2015;24(12):2615-27
pubmed: 25695896
Theranostics. 2019 Sep 21;9(23):6976-6990
pubmed: 31660081
Compr Physiol. 2015 Sep 20;5(4):1841-75
pubmed: 26426469
Trends Mol Med. 2015 Oct;21(10):595-608
pubmed: 26432017
IUBMB Life. 2020 Oct 26;:
pubmed: 33108032
Cells. 2019 Sep 10;8(9):
pubmed: 31510042
Circ Res. 2015 Jun 19;117(1):52-64
pubmed: 25904597
Blood. 2010 Sep 30;116(13):2385-94
pubmed: 20558614
Blood. 1999 Dec 1;94(11):3791-9
pubmed: 10572093
Nature. 2009 Mar 26;458(7237):445-52
pubmed: 19325624
PLoS One. 2012;7(3):e33115
pubmed: 22431999
Eur Heart J. 2013 Mar;34(10):782-9
pubmed: 22173909
J Mol Med (Berl). 2014 Apr;92(4):387-97
pubmed: 24337504
Acta Pharm Sin B. 2016 Jul;6(4):287-96
pubmed: 27471669
Oncotarget. 2015 May 10;6(13):11327-41
pubmed: 25857301
Diabetologia. 2014 Aug;57(8):1664-73
pubmed: 24838680
JCI Insight. 2019 Dec 19;4(24):
pubmed: 31689240
Stem Cells Transl Med. 2019 May;8(5):490-499
pubmed: 30706999
Am J Pathol. 2006 Dec;169(6):2127-36
pubmed: 17148675
Stem Cells. 2018 Jan;36(1):79-90
pubmed: 29076623
J Neurosci. 2010 May 19;30(20):6838-51
pubmed: 20484626
J Extracell Vesicles. 2022 Apr;11(4):e12207
pubmed: 35398993
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
Int Immunopharmacol. 2019 Jul;72:264-274
pubmed: 31005036
PLoS One. 2014 Feb 04;9(2):e87853
pubmed: 24504266
Lancet. 2012 Jan 14;379(9811):165-80
pubmed: 21840587
Circ Res. 2018 Jan 19;122(2):296-309
pubmed: 29118058
Exp Cell Res. 2010 Jul 15;316(12):1977-84
pubmed: 20399774
J Hematol Oncol. 2015 Oct 29;8:122
pubmed: 26514126
Int J Cardiol. 2015 Aug 1;192:61-9
pubmed: 26000464
Drug Deliv. 2020 Dec;27(1):585-598
pubmed: 32264719
Stem Cell Res. 2007 Nov;1(2):129-37
pubmed: 19383393
Mol Ther. 2015 May;23(5):812-823
pubmed: 25868399
Biomaterials. 2014 Feb;35(7):2383-90
pubmed: 24345736
Arthritis Rheum. 2009 Feb;60(2):380-9
pubmed: 19180475
Front Immunol. 2022 Sep 05;13:946358
pubmed: 36131943
PLoS One. 2012;7(4):e34653
pubmed: 22506041
Front Cell Dev Biol. 2022 Jun 01;10:875376
pubmed: 35721498
Stem Cell Res Ther. 2020 Jul 8;11(1):274
pubmed: 32641100
Cell Death Differ. 2016 Jun;23(6):962-78
pubmed: 26915293
Int J Mol Sci. 2016 Feb 06;17(2):172
pubmed: 26861303
Methods Mol Biol. 2021;2174:143-170
pubmed: 32813249
J Extracell Vesicles. 2018 Nov 23;7(1):1535750
pubmed: 30637094
Int Arch Allergy Immunol. 2001 Jan-Mar;124(1-3):133-6
pubmed: 11306949
Pharmacol Res. 2016 Nov;113(Pt B):816-822
pubmed: 26855317
Stem Cells Dev. 2013 Mar 15;22(6):845-54
pubmed: 23002959
Circulation. 2022 Feb 22;145(8):e153-e639
pubmed: 35078371
Lancet. 2012 Mar 10;379(9819):895-904
pubmed: 22336189
Sci Transl Med. 2021 Jul 7;13(601):
pubmed: 34233949
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
Br J Pharmacol. 2022 Sep;179(17):4281-4299
pubmed: 34028798
Sci Rep. 2017 Nov 24;7(1):16214
pubmed: 29176667
Cytotherapy. 2019 Jun;21(6):581-592
pubmed: 30979664
Crit Rev Clin Lab Sci. 2016 Dec;53(6):379-95
pubmed: 27191915
Int J Mol Sci. 2021 Aug 18;22(16):
pubmed: 34445618
J Extracell Vesicles. 2014 Nov 13;3:24722
pubmed: 25398455
J Control Release. 2015 May 10;205:35-44
pubmed: 25483424
J Cardiovasc Pharmacol Ther. 2019 Jan;24(1):70-77
pubmed: 30060693
J Leukoc Biol. 2022 Jan;111(1):63-74
pubmed: 34730839
J Extracell Vesicles. 2013 Feb 15;2:
pubmed: 24009890
J Immunol. 2008 Jul 15;181(2):1519-25
pubmed: 18606707
J Extracell Vesicles. 2020 Dec;10(2):e12044
pubmed: 33489012
EBioMedicine. 2016 Jun;8:72-82
pubmed: 27428420
Stem Cell Res Ther. 2020 Jan 3;11(1):11
pubmed: 31900218
Stem Cell Res Ther. 2020 Jun 29;11(1):259
pubmed: 32600435
Cell Death Dis. 2022 Jul 4;13(7):580
pubmed: 35787632
Immunology. 2018 Jun;154(2):204-219
pubmed: 29513402
RNA Biol. 2019 Jan;16(1):5-12
pubmed: 30604646
Front Cell Dev Biol. 2020 Jan 10;7:368
pubmed: 31998720
Curr Opin Crit Care. 2021 Dec 1;27(6):553-559
pubmed: 34535002
Eur Heart J. 2017 Jan 14;38(3):201-211
pubmed: 28158410
Neuropsychiatr Dis Treat. 2007 Jun;3(3):365-72
pubmed: 19300567
Sci Transl Med. 2021 Mar 10;13(584):
pubmed: 33692129
Cell Death Dis. 2020 May 11;11(5):354
pubmed: 32393784
J Biomed Sci. 2019 May 11;26(1):35
pubmed: 31078138
Annu Rev Cell Dev Biol. 2003;19:397-422
pubmed: 14570575
Stroke. 2018 May;49(5):1248-1256
pubmed: 29650593
J Transl Med. 2015 Feb 01;13:49
pubmed: 25638205
Front Mol Biosci. 2021 Jul 21;8:699929
pubmed: 34368228
Heart. 2005 May;91 Suppl 2:ii7-13; discussion ii31, ii43-8
pubmed: 15831613
J Mol Biol. 2016 Feb 22;428(4):688-692
pubmed: 26434508
J Lipid Res. 2018 Nov;59(11):2037-2046
pubmed: 29678959
Int J Mol Sci. 2020 Jan 05;21(1):
pubmed: 31948013
J Extracell Vesicles. 2019 Aug 1;8(1):1648167
pubmed: 31489144
Int J Mol Sci. 2022 Jun 24;23(13):
pubmed: 35806058
J Extracell Vesicles. 2016 Oct 31;5:32945
pubmed: 27802845
Clin Kidney J. 2015 Feb;8(1):23-30
pubmed: 25713706
Stem Cell Res Ther. 2021 Jan 6;12(1):4
pubmed: 33407872
Pharmacol Ther. 2022 May;233:108025
pubmed: 34687770
Int J Mol Sci. 2021 Apr 08;22(8):
pubmed: 33917759
Int J Mol Sci. 2018 Jun 09;19(6):
pubmed: 29890746
Nat Cell Biol. 2012 Oct;14(10):1036-45
pubmed: 22983114
Regen Med. 2010 Jan;5(1):121-43
pubmed: 20017699
Front Immunol. 2022 Jul 07;13:923598
pubmed: 35874757
J Extracell Vesicles. 2014 Sep 18;3:
pubmed: 25317274
Front Immunol. 2019 Oct 16;10:2346
pubmed: 31749791
J Inflamm Res. 2022 Mar 01;15:1421-1436
pubmed: 35256850
J Extracell Vesicles. 2021 Jun;10(8):e12094
pubmed: 34136108
JCI Insight. 2019 Jun 11;5:
pubmed: 31184999
FASEB J. 2019 May;33(5):5836-5849
pubmed: 30753093
FASEB J. 2021 Sep;35(9):e21332
pubmed: 34423867
Int J Mol Sci. 2021 Jun 15;22(12):
pubmed: 34203956
J Am Coll Cardiol. 2020 Dec 22;76(25):2982-3021
pubmed: 33309175
Int J Mol Sci. 2020 Jul 05;21(13):
pubmed: 32635660
Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11172-7
pubmed: 16837572
Traffic. 2009 Jul;10(7):925-37
pubmed: 19490536
Mol Ther. 2014 Mar;22(3):522-534
pubmed: 23939022
Stem Cell Res Ther. 2015 Apr 10;6:10
pubmed: 26268554