Silent neonatal influenza A virus infection primes systemic antimicrobial immunity.
Staphylococcus aureus
antimicrobial immunity
influenza A virus
influenza vaccination
innate immunity training
neonate
sepsis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2023
2023
Historique:
received:
17
10
2022
accepted:
09
01
2023
entrez:
10
2
2023
pubmed:
11
2
2023
medline:
14
2
2023
Statut:
epublish
Résumé
Infections with influenza A viruses (IAV) cause seasonal epidemics and global pandemics. The majority of these infections remain asymptomatic, especially among children below five years of age. Importantly, this is a time, when immunological imprinting takes place. Whether early-life infections with IAV affect the development of antimicrobial immunity is unknown. Using a preclinical mouse model, we demonstrate here that silent neonatal influenza infections have a remote beneficial impact on the later control of systemic juvenile-onset and adult-onset infections with an unrelated pathogen,
Identifiants
pubmed: 36761727
doi: 10.3389/fimmu.2023.1072142
pmc: PMC9902881
doi:
Substances chimiques
Influenza Vaccines
0
Anti-Infective Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1072142Informations de copyright
Copyright © 2023 Heinemann, Stalp, Bonifacio, Silva, Willers, Heckmann, Fehlhaber, Völlger, Raafat, Normann, Klos, Hansen, Schmolke and Viemann.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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