Phenotypic plasticity of malignant T cells in blood and skin of a Sézary syndrome patient revealed by single cell transcriptomics.

Sézary syndrome cutaneous T cell lymphoma inflammation malignant T cells reactive T cells scRNAseq

Journal

Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867

Informations de publication

Date de publication:
2023
Historique:
received: 05 11 2022
accepted: 03 01 2023
entrez: 10 2 2023
pubmed: 11 2 2023
medline: 11 2 2023
Statut: epublish

Résumé

Sézary Syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas (CTCL). In SS patients, malignant T cells are circulating through the blood and cause erythroderma. To compare the transcriptome of single cells in blood and skin samples from a patient with advanced SS. We utilized combined single cell RNA and T-cell receptor (TCR) sequencing (scRNA-seq). We scrutinized the malignant T cells in blood and skin in an unbiased manner without pre-sorting of cells. We observed different phenotypes of the same monoclonal malignant T-cell population, confirmed by TCR sequencing and inferred copy number variation analysis. Malignant T cells present in the circulating blood expressed genes resembling central memory T cells such as Using scRNA-seq we detected a high degree of functional heterogeneity within the malignant T-cell population in SS and highlighted crucial differences between SS cells in blood and skin.

Sections du résumé

Background UNASSIGNED
Sézary Syndrome (SS) is an aggressive leukemic variant of cutaneous T-cell lymphomas (CTCL). In SS patients, malignant T cells are circulating through the blood and cause erythroderma.
Objective UNASSIGNED
To compare the transcriptome of single cells in blood and skin samples from a patient with advanced SS.
Methods UNASSIGNED
We utilized combined single cell RNA and T-cell receptor (TCR) sequencing (scRNA-seq).
Results UNASSIGNED
We scrutinized the malignant T cells in blood and skin in an unbiased manner without pre-sorting of cells. We observed different phenotypes of the same monoclonal malignant T-cell population, confirmed by TCR sequencing and inferred copy number variation analysis. Malignant T cells present in the circulating blood expressed genes resembling central memory T cells such as
Conclusions UNASSIGNED
Using scRNA-seq we detected a high degree of functional heterogeneity within the malignant T-cell population in SS and highlighted crucial differences between SS cells in blood and skin.

Identifiants

pubmed: 36761972
doi: 10.3389/fonc.2023.1090592
pmc: PMC9905421
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1090592

Informations de copyright

Copyright © 2023 Peiffer, Gambichler, Buus, Horny, Gravemeyer, Furtmann, Spassova, Kubat, Susok, Stranzenbach, Srinivas, Ødum and Becker.

Déclaration de conflit d'intérêts

TG has received speakers and/or advisory board honoraria from BMS, Sanofi, MSD, Novartis Pharma, Janssen, Roche, Sun-Pharma, Abbvie, Almirall, Janssen, Lilly, Pfizer, Pierre Fabre, Merck-Serono, outside the submitted work. RS has received speakers and/or honoraria from Kyowa Kirin, Takeda, Novartis and Recordati Rare Diseases. LS has received speakers and/or advisory board honoraria from BMS, Sun-Pharma, MSD, and Novartis. JB is receiving speaker's bureau honoraria from Amgen, Pfizer, Recordati and Sanofi, is a paid consultant/advisory board member/DSMB member for Almirall, Boehringer Ingelheim, InProTher, ICON, Merck-Serono, Pfizer, 4SC, and Sanofi. His group receives research grants from Merck Serono, HTG, IQVIA, and Alcedis. All other authors have no conflict of interest to declare.

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Auteurs

Lukas Peiffer (L)

Translational Skin Cancer Research, Deutsches Konsortium für Translationale Krebsforschung (DKTK), Essen, Germany.
Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Thilo Gambichler (T)

Skin Cancer Center, Department of Dermatology, Venereology, and Allergology, Ruhr-University, Bochum, Germany.

Terkild B Buus (TB)

Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Kai Horny (K)

Translational Skin Cancer Research, Deutsches Konsortium für Translationale Krebsforschung (DKTK), Essen, Germany.
Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.

Jan Gravemeyer (J)

Translational Skin Cancer Research, Deutsches Konsortium für Translationale Krebsforschung (DKTK), Essen, Germany.
Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.

Frauke Furtmann (F)

Department of Dermatology, University of Essen, Essen, Germany.

Ivelina Spassova (I)

Translational Skin Cancer Research, Deutsches Konsortium für Translationale Krebsforschung (DKTK), Essen, Germany.
Department of Dermatology, University of Essen, Essen, Germany.

Linda Kubat (L)

Translational Skin Cancer Research, Deutsches Konsortium für Translationale Krebsforschung (DKTK), Essen, Germany.
Department of Dermatology, University of Essen, Essen, Germany.

Laura Susok (L)

Skin Cancer Center, Department of Dermatology, Venereology, and Allergology, Ruhr-University, Bochum, Germany.

René Stranzenbach (R)

Skin Cancer Center, Department of Dermatology, Venereology, and Allergology, Ruhr-University, Bochum, Germany.

Nalini Srinivas (N)

Translational Skin Cancer Research, Deutsches Konsortium für Translationale Krebsforschung (DKTK), Essen, Germany.
Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.

Niels Ødum (N)

Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark.

Jürgen C Becker (JC)

Translational Skin Cancer Research, Deutsches Konsortium für Translationale Krebsforschung (DKTK), Essen, Germany.
Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany.
Department of Dermatology, University of Essen, Essen, Germany.

Classifications MeSH