The ketogenic diet: its impact on human gut microbiota and potential consequent health outcomes: a systematic literature review.
Gut microbiota
Human
Ketogenic diet
Journal
Gastroenterology and hepatology from bed to bench
ISSN: 2008-2258
Titre abrégé: Gastroenterol Hepatol Bed Bench
Pays: Iran
ID NLM: 101525875
Informations de publication
Date de publication:
2022
2022
Historique:
received:
28
04
2022
accepted:
21
09
2022
entrez:
10
2
2023
pubmed:
11
2
2023
medline:
11
2
2023
Statut:
ppublish
Résumé
This systematic review examined the diet's impact on the human gut microbiota to identify potential consequent health outcomes. The extreme macronutrient profile of the ketogenic diet (KD) instigates compositional shifts in the gut's microbial community. In this systematic literature review, an evidence-based and methodical approach was undertaken, which involved systematic searches of the Medical Literature Analysis and Retrieval System Online (MEDLINE), PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases, generating a total of 263 relevant research papers. Following the application of inclusion and exclusion criteria, eight papers were deemed suitable for inclusion. These papers were critically appraised using a checklist tool adapted from the National Institute of Care and Excellence (NICE). The findings were analysed using a simplified thematic analysis. The results provide strong evidence for a persistent reduction in Changes to microbial communities resulting from KD adherence are potentially detrimental to colonic health. The persistent reduction in
Sections du résumé
Aim
UNASSIGNED
This systematic review examined the diet's impact on the human gut microbiota to identify potential consequent health outcomes.
Background
UNASSIGNED
The extreme macronutrient profile of the ketogenic diet (KD) instigates compositional shifts in the gut's microbial community.
Methods
UNASSIGNED
In this systematic literature review, an evidence-based and methodical approach was undertaken, which involved systematic searches of the Medical Literature Analysis and Retrieval System Online (MEDLINE), PubMed and Cumulative Index to Nursing and Allied Health Literature (CINAHL) databases, generating a total of 263 relevant research papers. Following the application of inclusion and exclusion criteria, eight papers were deemed suitable for inclusion. These papers were critically appraised using a checklist tool adapted from the National Institute of Care and Excellence (NICE). The findings were analysed using a simplified thematic analysis.
Results
UNASSIGNED
The results provide strong evidence for a persistent reduction in
Conclusion
UNASSIGNED
Changes to microbial communities resulting from KD adherence are potentially detrimental to colonic health. The persistent reduction in
Identifiants
pubmed: 36762214
doi: 10.22037/ghfbb.v15i4.2600
pmc: PMC9876773
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
326-342Déclaration de conflit d'intérêts
The authors declare that there is no conflict of interests with respect to the research, authorship or publication of this article.
Références
Nutrients. 2014 Dec 24;7(1):17-44
pubmed: 25545101
Physiol Behav. 2016 Oct 1;164(Pt B):488-493
pubmed: 27090230
Epilepsia. 2008 Nov;49 Suppl 8:3-5
pubmed: 19049574
Diabetes. 2010 Jan;59(1):172-81
pubmed: 19794059
Diabetes Res Clin Pract. 2014 Nov;106(2):173-81
pubmed: 25193333
Am J Gastroenterol. 2011 Apr;106(4):563-73
pubmed: 21468064
Environ Microbiol. 2012 Oct 15;:
pubmed: 23286720
Nature. 2018 Mar 29;555(7698):623-628
pubmed: 29555994
Int J Food Sci Nutr. 2018 Dec;69(8):904-915
pubmed: 29516760
Epilepsy Res. 2018 Sep;145:163-168
pubmed: 30007242
Front Microbiol. 2016 Jun 28;7:979
pubmed: 27446020
J Appl Microbiol. 2003;94(1):138-45
pubmed: 12492934
Science. 2013 Jul 5;341(6141):1237439
pubmed: 23828941
Diabetes. 2008 Jun;57(6):1470-81
pubmed: 18305141
Annu Rev Nutr. 2006;26:1-22
pubmed: 16848698
Nat Rev Immunol. 2017 Apr;17(4):219-232
pubmed: 28260787
Front Neurosci. 2018 Feb 07;12:49
pubmed: 29467611
Diabetes. 2010 Dec;59(12):3049-57
pubmed: 20876719
Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1045-50
pubmed: 14722361
PLoS One. 2016 Aug 23;11(8):e0161635
pubmed: 27551722
Int J Food Microbiol. 2011 Sep 1;149(1):88-105
pubmed: 21763022
Am J Med Genet A. 2006 Mar 1;140(5):515-24
pubmed: 16463275
PLoS Med. 2009 Jul 21;6(7):e1000097
pubmed: 19621072
Nutrients. 2019 Feb 12;11(2):
pubmed: 30759766
Science. 2013 Jan 11;339(6116):211-4
pubmed: 23223453
Diabetes. 2012 Feb;61(2):364-71
pubmed: 22190648
Diabetes Metab Res Rev. 1999 Nov-Dec;15(6):412-26
pubmed: 10634967
Diabetes Care. 2003 Apr;26(4):1137-41
pubmed: 12663586
Open Biochem J. 2010 May 13;4:53-8
pubmed: 20563285
J Nutr. 2009 Sep;139(9):1619-25
pubmed: 19625695
Genome Biol. 2016 Oct 19;17(1):217
pubmed: 27760558
Semin Immunopathol. 2015 Jan;37(1):47-55
pubmed: 25420450
Dis Model Mech. 2015 Jan;8(1):1-16
pubmed: 25561744
Clin Nutr. 2019 Jun;38(3):1012-1022
pubmed: 30274898
Gastroenterology. 2017 Aug;153(2):448-459.e8
pubmed: 28483500
Protein Cell. 2018 May;9(5):474-487
pubmed: 29713943
Bioinformatics. 2015 Aug 1;31(15):2461-8
pubmed: 25819674
Microbiome. 2019 Jun 13;7(1):91
pubmed: 31196177
Int J Mol Sci. 2016 Jun 14;17(6):
pubmed: 27314323
Rev Esp Enferm Dig. 2015 Nov;107(11):659-71
pubmed: 26541655
Oxid Med Cell Longev. 2017;2017:3831972
pubmed: 28357027
Medicina (Kaunas). 2019 Mar 29;55(4):
pubmed: 30934960
Environ Microbiol. 2009 Oct;11(10):2574-84
pubmed: 19601958
Microb Ecol Health Dis. 2015 Feb 04;26:26164
pubmed: 25656825
mBio. 2019 Jul 2;10(4):
pubmed: 31266879
Environ Microbiol. 2009 Aug;11(8):2112-22
pubmed: 19397676
BMC Immunol. 2017 Jan 6;18(1):2
pubmed: 28061847
Nutr Rev. 2017 Apr 1;75(4):286-305
pubmed: 28402523
Pharmacol Res. 2013 Mar;69(1):52-60
pubmed: 23147033
J Appl Microbiol. 2012 Aug;113(2):411-7
pubmed: 22612585
J Pak Med Assoc. 2018 Dec;68(12):1836-1839
pubmed: 30504952
ISME J. 2015 Jan;9(1):1-15
pubmed: 24936764
World J Mens Health. 2020 Jan;38(1):48-60
pubmed: 30929328
World J Gastroenterol. 2013 Jun 14;19(22):3404-14
pubmed: 23801832
Pract Neurol. 2016 Jun;16(3):208-14
pubmed: 26908897
Nature. 2012 May 09;486(7402):222-7
pubmed: 22699611
Nature. 2014 Jan 23;505(7484):559-63
pubmed: 24336217
Curr Microbiol. 2010 Jul;61(1):69-78
pubmed: 20087741
Nat Rev Microbiol. 2018 Oct;16(10):647-655
pubmed: 29691482
Cell Metab. 2018 Mar 6;27(3):559-571.e5
pubmed: 29456073
Nutrients. 2021 May 13;13(5):
pubmed: 34068325
Aliment Pharmacol Ther. 2016 Jan;43(2):181-96
pubmed: 26527169
Am J Clin Nutr. 2013 May;97(5):1044-52
pubmed: 23553152
Clin Nutr ESPEN. 2017 Feb;17:33-37
pubmed: 28361745
Nutrients. 2019 Apr 26;11(5):
pubmed: 31035514
Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):E8141-E8150
pubmed: 27911839
BMJ Open. 2014 Aug 25;4(8):e005047
pubmed: 25157183
Int J Environ Res Public Health. 2014 Feb 19;11(2):2092-107
pubmed: 24557522
J Psychiatr Res. 2008 Dec;43(2):164-74
pubmed: 18456279
mBio. 2019 Jan 29;10(1):
pubmed: 30696735
Mol Autism. 2016 Sep 01;7(1):37
pubmed: 27594980
Neurogastroenterol Motil. 2011 Dec;23(12):1132-9
pubmed: 21988661
PLoS One. 2012;7(12):e52078
pubmed: 23284876
World J Gastroenterol. 2017 Mar 28;23(12):2124-2140
pubmed: 28405140
Am J Clin Nutr. 2011 May;93(5):1062-72
pubmed: 21389180
JPEN J Parenter Enteral Nutr. 2008 Sep-Oct;32(5):567-8
pubmed: 18753394
Arch Med Res. 2017 Nov;48(8):727-734
pubmed: 29221800
Front Microbiol. 2017 Jun 28;8:1141
pubmed: 28702003
Int J Food Sci Nutr. 2018 Mar;69(2):125-143
pubmed: 28675945
Science. 2011 Oct 7;334(6052):105-8
pubmed: 21885731
Gut Microbes. 2016 May 3;7(3):189-200
pubmed: 26963409
Nutrients. 2019 Sep 23;11(10):
pubmed: 31547555
Nutr Res Pract. 2015 Aug;9(4):343-9
pubmed: 26244071
Mol Nutr Food Res. 2017 Jul;61(7):
pubmed: 27813269
Cell Metab. 2017 Sep 5;26(3):523-538.e5
pubmed: 28877456
Microbiome. 2015 Jul 30;3:31
pubmed: 26229597
Arch Oral Biol. 2010 Aug;55(8):555-60
pubmed: 20541177
Signal Transduct Target Ther. 2022 Jan 17;7(1):11
pubmed: 35034957
Nat Commun. 2014 May 21;5:3944
pubmed: 24845831
Clin Transl Immunology. 2016 Apr 22;5(4):e73
pubmed: 27195116
Microb Cell Fact. 2014 Aug 29;13 Suppl 1:S4
pubmed: 25186128
BMC Pediatr. 2015 May 30;15:64
pubmed: 26024884
Front Microbiol. 2018 Aug 14;9:1835
pubmed: 30154767
Carcinogenesis. 2010 Feb;31(2):246-51
pubmed: 19696163
Front Microbiol. 2016 Feb 17;7:185
pubmed: 26925050
Genes (Basel). 2019 Jul 15;10(7):
pubmed: 31311141
J Affect Disord. 2012 Dec 1;141(1):55-62
pubmed: 22410503
PeerJ. 2018 Mar 16;6:e4488
pubmed: 29576959
ISME J. 2012 Feb;6(2):320-9
pubmed: 21850056
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16767-72
pubmed: 18931303
J Affect Disord. 2016 Sep 15;202:254-7
pubmed: 27288567
J Appl Microbiol. 2014 Mar;116(3):477-91
pubmed: 24314205
Br J Nutr. 2009 May;101(10):1493-502
pubmed: 19224658
Microb Ecol Health Dis. 2015 Feb 02;26:26050
pubmed: 25651996
Nature. 2012 Sep 13;489(7415):220-30
pubmed: 22972295
Cochrane Database Syst Rev. 2017 Jan 08;1:CD003430
pubmed: 28064440
Mol Nutr Food Res. 2017 Jan;61(1):
pubmed: 27287778
Diabetes. 2007 Jul;56(7):1761-72
pubmed: 17456850
Science. 2015 Nov 27;350(6264):1084-9
pubmed: 26541606
Gut. 2016 Feb;65(2):330-9
pubmed: 26338727
Front Microbiol. 2016 Aug 19;7:1204
pubmed: 27594848
Eur J Clin Invest. 2016 Mar;46(3):285-98
pubmed: 26782788
Nutrients. 2019 Apr 24;11(4):
pubmed: 31022973
Cell. 2020 Jun 11;181(6):1263-1275.e16
pubmed: 32437658
Am J Clin Nutr. 2007 Aug;86(2):276-84
pubmed: 17684196
Gut Microbes. 2017 Mar 4;8(2):172-184
pubmed: 28165863
Biomed J. 2013 Jan-Feb;36(1):9-15
pubmed: 23515148
Neurochem Int. 2016 Oct;99:110-132
pubmed: 27346602
Cell Metab. 2017 Feb 7;25(2):262-284
pubmed: 28178565
Obes Rev. 2006 Feb;7(1):49-58
pubmed: 16436102
Int J Obes (Lond). 2008 Nov;32(11):1720-4
pubmed: 18779823
J Lipid Res. 2013 Sep;54(9):2325-40
pubmed: 23821742
PLoS Biol. 2016 Aug 19;14(8):e1002533
pubmed: 27541692
ISME J. 2011 Feb;5(2):220-30
pubmed: 20686513
World J Gastroenterol. 2016 Jan 21;22(3):895-905
pubmed: 26811635
Front Microbiol. 2016 Jun 15;7:925
pubmed: 27379055
Nutrients. 2019 Jan 24;11(2):
pubmed: 30682843
Front Psychol. 2015 Oct 06;6:1520
pubmed: 26500584
Front Microbiol. 2018 Sep 11;9:2013
pubmed: 30258412
Nature. 2011 May 12;473(7346):174-80
pubmed: 21508958
Diseases. 2018 Sep 06;6(3):
pubmed: 30200574
Lipids Health Dis. 2016 Nov 5;15(1):186
pubmed: 27816052
Dig Dis Sci. 2018 Dec;63(12):3167-3177
pubmed: 30267172
Cell. 2016 Jun 2;165(6):1332-1345
pubmed: 27259147
Appl Environ Microbiol. 2007 Feb;73(4):1073-8
pubmed: 17189447
Trends Microbiol. 2015 Jun;23(6):354-66
pubmed: 25840765
Adv Enzyme Regul. 1966;4:339-54
pubmed: 4865971
Epilepsy Res. 2012 Jul;100(3):278-85
pubmed: 22771252
Neuron. 2019 Apr 3;102(1):75-90
pubmed: 30946828
Clin Transl Gastroenterol. 2016 Apr 07;7:e161
pubmed: 27054579
Aliment Pharmacol Ther. 2015 Jul;42(2):158-79
pubmed: 26011307
Am J Clin Nutr. 2008 May;87(5):1219-23
pubmed: 18469242
Br J Nutr. 2012 Aug;108 Suppl 2:S105-12
pubmed: 23107521
Nutrients. 2019 Jan 24;11(2):
pubmed: 30678355
Int J Obes (Lond). 2013 Nov;37(11):1460-6
pubmed: 23459324
Nutrients. 2021 Dec 31;14(1):
pubmed: 35011071
Neurobiol Dis. 2020 Feb;135:104578
pubmed: 31454550
J Transl Med. 2017 Apr 8;15(1):73
pubmed: 28388917
J Bacteriol. 1967 Feb;93(2):574-6
pubmed: 6020562
J Family Med Prim Care. 2013 Jan;2(1):9-14
pubmed: 24479036
Appl Environ Microbiol. 2006 Feb;72(2):1027-33
pubmed: 16461645
Nutrients. 2018 May 08;10(5):
pubmed: 29738477
J Formos Med Assoc. 2019 Mar;118 Suppl 1:S3-S9
pubmed: 30057153