Label-Free Mass Spectrometry Proteomics Reveals Different Pathways Modulated in THP-1 Cells Infected with Therapeutic Failure and Drug Resistance
Leishmania drug resistance
Leishmania treatment failure
bioinformatics
human macrophages
leishmaniasis
mass spectrometry
proteomics
Journal
ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580
Informations de publication
Date de publication:
10 03 2023
10 03 2023
Historique:
pubmed:
11
2
2023
medline:
14
3
2023
entrez:
10
2
2023
Statut:
ppublish
Résumé
As the world is facing increasing difficulties to treat leishmaniasis with current therapies, deeper investigation into the molecular mechanisms responsible for both drug resistance and treatment failure (TF) is essential in drug discovery and development. So far, few available drugs cause severe side effects and have developed several resistance mechanisms. Drug resistance and TF parasite strains from clinical isolates may have acquired altered expression of proteins that characterize specific mechanisms leading to therapy inefficacy. This work aims to identify the biochemical pathways of THP-1 human monocytes infected by different
Identifiants
pubmed: 36762976
doi: 10.1021/acsinfecdis.2c00457
pmc: PMC10012269
doi:
Substances chimiques
Antiprotozoal Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
470-485Références
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