Tetracycline-, Doxycycline-, Minocycline-Induced Pseudotumor Cerebri and Esophageal Perforation.
Adolescent
Humans
Minocycline
/ adverse effects
Doxycycline
/ adverse effects
Tetracycline
/ adverse effects
Pseudotumor Cerebri
/ chemically induced
Esophageal Perforation
/ chemically induced
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
/ adverse effects
Acne Vulgaris
/ chemically induced
Esophagitis
/ chemically induced
Pain
/ drug therapy
Esophageal perforation
Esophagitis
IIH
Intracranial pressure
Pseudotumor cerebri
Tetracyclines
Journal
Advances in therapy
ISSN: 1865-8652
Titre abrégé: Adv Ther
Pays: United States
ID NLM: 8611864
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
26
08
2022
accepted:
17
01
2023
medline:
5
4
2023
pubmed:
11
2
2023
entrez:
10
2
2023
Statut:
ppublish
Résumé
Tetracyclines are a class of broad-spectrum bacteriostatic antibiotics used to treat many infections, including methicillin-resistant Staphylococcus aureus (MRSA), acne, pelvic inflammatory disease, chlamydial infections, and a host of zoonotic infections. These drugs work by inhibiting protein synthesis in bacterial ribosomes, specifically by disallowing aminoacyl-tRNA molecules from binding to the ribosomal acceptor sites. While rare, tetracycline antibiotics, particularly minocycline and doxycycline, are associated with an increased risk of developing esophageal perforation and pseudotumor cerebri (PTC, or idiopathic intracranial hypertension). Since tetracyclines are a commonly prescribed class of medications, especially in adolescents for acne treatment, it is important for clinicians to appreciate significant side effects that can result in morbidity and mortality. This paper aims to consolidate and to emphasize current research on the association between tetracycline antibiotics and the development of esophageal perforation, and PTC. PTC is a neurological syndrome consisting of increased intracranial pressure, headache, and vision changes without evidence of the contributing source, such as mass lesion, infection, stroke, or malignancy. Esophageal perforation, while rare, can be the result of pill esophagitis. Pill-induced injuries occur when caustic medicinal pills dissolve in the esophagus rather than in the stomach. Most patients experience only self-limited pain (retrosternal burning discomfort, heartburn, dysphagia, or odynophagia), but hemorrhage, stricture, and perforation may occur. Tetracycline use can lead to pill esophagitis. In summary, clinicians should appreciate the potential risks of tetracycline compounds in clinical practice.
Identifiants
pubmed: 36763302
doi: 10.1007/s12325-023-02435-y
pii: 10.1007/s12325-023-02435-y
doi:
Substances chimiques
Minocycline
FYY3R43WGO
Doxycycline
N12000U13O
Tetracycline
F8VB5M810T
Anti-Bacterial Agents
0
Types de publication
Journal Article
Review
Langues
eng
Pagination
1366-1378Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Références
Shutter MC, Akhondi H. Tetracycline. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2022. http://www.ncbi.nlm.nih.gov/books/NBK549905/ . Accessed 05 Aug 2022.
Shutter MC, Akhondi H. Tetracycline. Kucers use antibiot. Clin. rev. antibact. antifung. antiparasit. antivir. Drugs, 7th edn. pp. 1195–1203 (2022). https://doi.org/10.1201/9781315152110 .
Kassem MM, Wallen JM. Esophageal perforation and tears. StatPearls (2021)
Mondragon J, Klovenski V. Pseudotumor cerebri. StatPearls (2022).
Jensen RH, Radojicic A, Yri H. The diagnosis and management of idiopathic intracranial hypertension and the associated headache. Ther Adv Neurol Disord. 2016;9(4):317–26. https://doi.org/10.1177/1756285616635987 .
doi: 10.1177/1756285616635987
pubmed: 27366239
pmcid: 4916517
Mondragon J, Klovenski V. Pseudotumor cerebri. StatPearls Publishing, 2022. https://www.ncbi.nlm.nih.gov/books/NBK536924/ . Accessed 01 Aug 2022.
Sharma S, Hashmi MF, Kumar A. Intracranial hypertension. StatPearls Publishing, 2022. https://www.ncbi.nlm.nih.gov/books/NBK507811/ . Accessed 01 Aug 2022.
Kaman L, Iqbal J, Kundil B, Kochhar R. Management of esophageal perforation in adults. Gastroenterol Res. 2010;3(6):235–44. https://doi.org/10.4021/gr263w .
doi: 10.4021/gr263w
Søreide JA, Viste A. Esophageal perforation: diagnostic work-up and clinical decision-making in the first 24 hours. Scand J Trauma Resusc Emerg Med. 2011;19:66. https://doi.org/10.1186/1757-7241-19-66 .
doi: 10.1186/1757-7241-19-66
pubmed: 22035338
pmcid: 3219576
Kassem MM, Wallen JM. Esophageal perforation and tears. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2022. http://www.ncbi.nlm.nih.gov/books/NBK532298/ . Accessed 01 Aug 2022.
Agwuh KN. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006;58(2):256–65. https://doi.org/10.1093/jac/dkl224 .
doi: 10.1093/jac/dkl224
pubmed: 16816396
Patel RS, Parmar M. Doxycycline hyclate. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2022. http://www.ncbi.nlm.nih.gov/books/NBK555888/ . Accessed 05 Aug 2022.
Shutter MC, Akhondi H. Tetracycline. StatPearls Publishing, 2022. https://www.ncbi.nlm.nih.gov/books/NBK549905 . Accessed 04 Aug 2022.
Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. Oxford Academic. https://academic.oup.com/jac/article/58/2/256/718565#12624688 . Accessed 04 Aug 2022.
Antunes C, Sharma A. Esophagitis. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2022. http://www.ncbi.nlm.nih.gov/books/NBK442012/ . Accessed 05 Aug 2022.
Saleem F, Sharma A. Drug induced esophagitis. In: StatPearls. Treasure Island (FL): StatPearls Publishing, 2022. http://www.ncbi.nlm.nih.gov/books/NBK549818/ . Accessed 05 Aug 2022.
Guo Y, Li H-M, Li C-X, Zhu W-Q, Wang Y-F, He Y-H. Oesophageal ulceration in adult patients treated with doxycycline for acne vulgaris. J Int Med Res. 2019;47(12):6404–9. https://doi.org/10.1177/0300060519881272 .
doi: 10.1177/0300060519881272
pubmed: 31709872
pmcid: 7045682
Guttman OR, Zachos M. Drug-induced esophageal injury with an occult vascular ring. Paediatr Child Health. 2011;16(9):554–6. https://doi.org/10.1093/pch/16.9.554 .
doi: 10.1093/pch/16.9.554
pubmed: 23115494
pmcid: 3223890
Holst AV, Danielsen PL, Romner B. A severe case of tetracycline-induced intracranial hypertension. Dermatol Rep. 2011;3(1):1. https://doi.org/10.4081/dr.2011.e1 .
doi: 10.4081/dr.2011.e1
Walters BN, Gubbay SS. Tetracycline and benign intracranial hypertension: report of five cases. BMJ. 1981;282(6257):19–20. https://doi.org/10.1136/bmj.282.6257.19 .
doi: 10.1136/bmj.282.6257.19
pubmed: 6449976
pmcid: 1503750
Lee AG. Pseudotumor cerebri after treatment with tetracycline and isotretinoin for acne. Cutis. 1995;55(3):165–8.
pubmed: 7634848
Minutello JS, Dimayuga RG, Carter J. Pseudotumor cerebri, a rare adverse reaction to tetracycline therapy: a case report. J Periodontol. 1988;59(12):848–51. https://doi.org/10.1902/jop.1988.59.12.848 .
doi: 10.1902/jop.1988.59.12.848
pubmed: 3225732
Mohamed AA, Lu XL, Mounmin FA. Diagnosis and treatment of esophageal candidiasis: current updates. Can J Gastroenterol Hepatol. 2019;20(2019):3585136. https://doi.org/10.1155/2019/3585136 .
doi: 10.1155/2019/3585136
Passi SF, Butcher R, Orme DR, Warner JEA, Stoddard GJ, Crum AV, Gouripeddi R, Kirk BH, Digre KB, Katz BJ. Increased incidence of pseudotumor cerebri syndrome among users of tetracycline antibiotics. J Neuroophthalmol. 2022;42(3):323–7. https://doi.org/10.1097/WNO.0000000000001536 . (Epub 2022 Mar 25).
doi: 10.1097/WNO.0000000000001536
pubmed: 35427251
Hexom B, Barthel RP. Lithium and pseudotumor cerebri. J Am Acad Child Adolesc Psychiatry. 2004;43(3):247–8. https://doi.org/10.1097/00004583-200403000-00003 .
doi: 10.1097/00004583-200403000-00003
pubmed: 15076255
Burkett JG, Ailani J. An up to date review of pseudotumor cerebri syndrome. Curr Neurol Neurosci Rep. 2018;18(6):33. https://doi.org/10.1007/s11910-018-0839-1 .
doi: 10.1007/s11910-018-0839-1
pubmed: 29721718