Nr4a nuclear receptors: markers and modulators of antigen receptor signaling.
Journal
Current opinion in immunology
ISSN: 1879-0372
Titre abrégé: Curr Opin Immunol
Pays: England
ID NLM: 8900118
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
received:
19
11
2022
revised:
10
01
2023
accepted:
17
01
2023
pubmed:
11
2
2023
medline:
21
3
2023
entrez:
10
2
2023
Statut:
ppublish
Résumé
Nr4a1-3 encode a small family of orphan nuclear hormone receptors with transcriptional activity. Their expression reflects both acute and chronic antigen-receptor signaling in T and B-cells, and they have been implicated in critical aspects of lymphocyte development, tolerance, and function. These include roles in regulatory T-cell (Treg), thymic-negative selection, humoral responses, anergy, and exhaustion. Here, we review recent advances in this field such as functional roles in B-cells, transcriptional targets, and mechanism of action. We highlight recurrent themes, including integration of antigen-receptor signaling with costimulatory input, as well as unanswered questions and translational applications of this work.
Identifiants
pubmed: 36764055
pii: S0952-7915(23)00004-3
doi: 10.1016/j.coi.2023.102285
pii:
doi:
Substances chimiques
Receptors, Antigen
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
102285Subventions
Organisme : Medical Research Council
ID : MR/V009052/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI148487
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI165706
Pays : United States
Informations de copyright
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest statement JZ is a scientific advisor for Walking Fish Therapeutics. DB declares no conflicts of interest.