Cytokine levels in maternal and infant blood after COVID-19 vaccination during pregnancy in comparison with unvaccinated controls.

Pregnancy Female Infant Humans Cytokines COVID-19 Vaccines Prospective Studies COVID-19 / prevention & control SARS-CoV-2 Vaccination
COVID-19 Cytokines SARS-CoV-2 Vaccination

Journal

Journal of reproductive immunology
ISSN: 1872-7603
Titre abrégé: J Reprod Immunol
Pays: Ireland
ID NLM: 8001906

Informations de publication

Date de publication:
03 2023
Historique:
received: 02 11 2022
revised: 04 01 2023
accepted: 28 01 2023
pubmed: 11 2 2023
medline: 28 3 2023
entrez: 10 2 2023
Statut: ppublish

Résumé

The objective of this study was to compare maternal and infant cytokine profiles at delivery among those vaccinated against SARS-CoV-2 during pregnancy to unvaccinated controls. Mother-infant dyads were enrolled in this prospective cohort study, and maternal blood and infant and/or cord blood collected. Samples were analyzed utilizing a LEGENDplex 13-plex human anti-viral response cytokine panel. Maternal IP-10 and IFN-λ2/3 were lower in the vaccinated cohort. In the infants, levels were lower for IL-1β, IFN-λ2/3, and GM-CSF, and higher for IFN-λ1 in the vaccinated cohort. Vaccination against SARS-CoV-2 during pregnancy did not lead to elevations in cytokines in mothers or infants.

Identifiants

DOI: 10.1016/j.jri.2023.103821 PMID: 36764228 PMC: PMC9884398
pubmed: 36764228
pii: S0165-0378(23)00027-X
doi: 10.1016/j.jri.2023.103821
pmc: PMC9884398
pii:
doi:

Substances chimiques

Cytokines 0
COVID-19 Vaccines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

103821

Subventions

Organisme : NCATS NIH HHS
ID : UL1 TR001430
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2023 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interest None.

Auteurs

Vishakha Sabharwal (V)

Department of Pediatrics, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States of America. Electronic address: Vishakha.Sabharwal@bmc.org.

Riley Demos (R)

Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, United States of America. Electronic address: rdemos@bu.edu.

Jennifer Snyder-Cappione (J)

Department of Microbiology, Boston University School of Medicine, 650eAlbany Street, Boston, MA 02118, United States of America. Electronic address: cappione@bu.edu.

Samantha E Parker (SE)

Boston University School of Public Health, 715 Albany St, Boston, MA 02118, United States of America. Electronic address: separker@bu.edu.

Yazdan Shaik-Dasthagirisaheb (Y)

Department of Pediatrics, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States of America. Electronic address: bashasy@bu.edu.

Jessica Hunnewell (J)

Boston University School of Public Health, 715 Albany St, Boston, MA 02118, United States of America. Electronic address: jhunnew1@bu.edu.

Jeffery Boateng (J)

Department of Pediatrics, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States of America. Electronic address: jboateng@bu.edu.

Katherine Clarke (K)

Department of Microbiology, Boston University School of Medicine, 650eAlbany Street, Boston, MA 02118, United States of America. Electronic address: kmclarke@bu.edu.

Rachel Yuen (R)

Department of Microbiology, Boston University School of Medicine, 650eAlbany Street, Boston, MA 02118, United States of America. Electronic address: ryuen@bu.edu.

Elizabeth Barnett (E)

Department of Pediatrics, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States of America. Electronic address: Elizabeth.Barnett@bmc.org.

Christina Yarrington (C)

Department of Obstetrics and Gynecology, Boston Medical Center, Boston, MA 02118, United States of America. Electronic address: Christina.Yarrington@bmc.org.

Elizabeth Taglauer (E)

Department of Pediatrics, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States of America. Electronic address: Elizabeth.Taglauer@bmc.org.

Elisha M Wachman (EM)

Department of Pediatrics, Boston Medical Center, 670 Albany Street, Boston, MA 02118, United States of America. Electronic address: Elisha.Wachman@bmc.org.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Cytokine levels in maternal and infant blood...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Cytokine levels in maternal and infant blood...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cytokine levels in maternal and infant blood...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Cytokine levels in maternal and infant blood...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antiviraux › Vaccins contre la COVID-19 › Cytokine levels in maternal and infant blood...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Cytokine levels in maternal and infant blood...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Cytokine levels in maternal and infant blood...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Cytokine levels in maternal and infant blood...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Prévention primaire › Immunisation › Vaccination › Cytokine levels in maternal and infant blood...