Dysregulation of astrocytic Ca


Journal

Acta neuropathologica
ISSN: 1432-0533
Titre abrégé: Acta Neuropathol
Pays: Germany
ID NLM: 0412041

Informations de publication

Date de publication:
05 2023
Historique:
received: 20 12 2022
accepted: 01 02 2023
revised: 17 01 2023
medline: 24 4 2023
pubmed: 11 2 2023
entrez: 10 2 2023
Statut: ppublish

Résumé

α-Synuclein is a major component of Lewy bodies (LB) and Lewy neurites (LN) appearing in the postmortem brain of Parkinson's disease (PD) and other α-synucleinopathies. While most studies of α-synucleinopathies have focused on neuronal and synaptic alterations as well as dysfunctions of the astrocytic homeostatic roles, whether the bidirectional astrocyte-neuronal communication is affected in these diseases remains unknown. We have investigated whether the astrocyte Ca

Identifiants

pubmed: 36764943
doi: 10.1007/s00401-023-02547-3
pii: 10.1007/s00401-023-02547-3
pmc: PMC10119048
doi:

Substances chimiques

alpha-Synuclein 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

597-610

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS086074
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092093
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG074473
Pays : United States
Organisme : NINDS NIH HHS
ID : R56 NS113549
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS108686
Pays : United States

Commentaires et corrections

Type : ErratumIn

Informations de copyright

© 2023. The Author(s).

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Auteurs

Carmen Nanclares (C)

Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.

Jonah Poynter (J)

Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.

Hector A Martell-Martinez (HA)

Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.

Scott Vermilyea (S)

Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.
Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street SE, Minneapolis, MN, 55455, USA.

Alfonso Araque (A)

Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA.

Paulo Kofuji (P)

Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA. kofuj001@umn.edu.

Michael K Lee (MK)

Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA. mklee@umn.edu.
Institute for Translational Neuroscience, University of Minnesota, 2101 6th Street SE, Minneapolis, MN, 55455, USA. mklee@umn.edu.

Ana Covelo (A)

Department of Neuroscience, University of Minnesota, 4-125 Jackson Hall, 321 Church Street SE, Minneapolis, MN, 55455, USA. ana.covelo@inserm.fr.
Institut National de la Santé et de la Recherche Médicale (INSERM), U1215 NeuroCentre Magendie, 33077, Bordeaux, France. ana.covelo@inserm.fr.
University of Bordeaux, 33077, Bordeaux, France. ana.covelo@inserm.fr.

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Classifications MeSH