Computational modeling reveals inflammation-driven dilatation of the pulmonary autograft in aortic position.
Homogenized constrained mixture theory
Inflammation
Pulmonary interposition autograft
Vascular remodeling
Journal
Biomechanics and modeling in mechanobiology
ISSN: 1617-7940
Titre abrégé: Biomech Model Mechanobiol
Pays: Germany
ID NLM: 101135325
Informations de publication
Date de publication:
Oct 2023
Oct 2023
Historique:
received:
16
05
2022
accepted:
17
01
2023
medline:
22
9
2023
pubmed:
11
2
2023
entrez:
10
2
2023
Statut:
ppublish
Résumé
The pulmonary autograft in the Ross procedure, where the aortic valve is replaced by the patient's own pulmonary valve, is prone to failure due to dilatation. This is likely caused by tissue degradation and maladaptation, triggered by the higher experienced mechanical loads in aortic position. In order to further grasp the causes of dilatation, this study presents a model for tissue growth and remodeling of the pulmonary autograft, using the homogenized constrained mixture theory and equations for immuno- and mechano-mediated mass turnover. The model outcomes, compared to experimental data from an animal model of the pulmonary autograft in aortic position, show that inflammation likely plays an important role in the mass turnover of the tissue constituents and therefore in the autograft dilatation over time. We show a better match and prediction of long-term outcomes assuming immuno-mediated mass turnover, and show that there is no linear correlation between the stress-state of the material and mass production. Therefore, not only mechanobiological homeostatic adaption should be taken into account in the development of growth and remodeling models for arterial tissue in similar applications, but also inflammatory processes.
Identifiants
pubmed: 36764979
doi: 10.1007/s10237-023-01694-6
pii: 10.1007/s10237-023-01694-6
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1555-1568Subventions
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1A6519N
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1S70220
Organisme : Onderzoeksraad, KU Leuven
ID : C2-ADAPT
Informations de copyright
© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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