Pathogens associated with hospitalization due to acute lower respiratory tract infections in children in rural Ghana: a case-control study.
Humans
Child
Infant
Child, Preschool
Ghana
/ epidemiology
Influenza, Human
/ epidemiology
Case-Control Studies
COVID-19
SARS-CoV-2
Respiratory Tract Infections
/ epidemiology
Respiratory Syncytial Virus, Human
Streptococcus pneumoniae
Haemophilus influenzae
Hospitalization
Respiratory Syncytial Virus Infections
/ epidemiology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
10 02 2023
10 02 2023
Historique:
received:
28
09
2022
accepted:
03
02
2023
entrez:
10
2
2023
pubmed:
11
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Respiratory infections are one of the most common causes of death among children under the age of five years. Data on prevalence and relevance of specific organisms in African children are still lacking. This case-control-study investigated prevalence and relevance of specific organisms in Ghanaian children admitted to hospital with symptoms of lower respiratory tract infection (LRTI). Pharyngeal swabs were taken and tested by PCR for 19 respiratory isolates. Adjusted odds ratios (aORs) were calculated to estimate associations between isolates and admission with LRTI. Population attributable fractions (PAFs) were calculated to assess the proportion of LRTI cases due to a particular pathogen. The study included 327 cases and 562 controls. We found associations between detection and admission for LRTI for influenza (aOR 98.6; 95% confidence interval (CI) 20.0-1789.6), respiratory syncytial virus (aOR 40.2; 95% CI 7.2-758.6), H. influenzae (aOR 4.1; 95% CI 2.2-7.9) and S. pneumoniae (aOR 2.4; 95% CI 1.7-3.4). PAFs ≥ 10% were observed for S. pneumoniae (30%; 95% CI 26-42), H. influenzae (10%; 95% CI 2-19) and influenza (10%; 95% CI 2-18). This study highlights the need for heightened surveillance and development of effective vaccines for respiratory pathogens other than SARS-CoV-2 in the future.
Identifiants
pubmed: 36765075
doi: 10.1038/s41598-023-29410-5
pii: 10.1038/s41598-023-29410-5
pmc: PMC9916495
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2443Informations de copyright
© 2023. The Author(s).
Références
Clin Infect Dis. 2009 Jul 1;49(1):124-31
pubmed: 19480579
Clin Infect Dis. 2017 Aug 15;65(4):604-612
pubmed: 28605562
BMC Infect Dis. 2017 Feb 8;17(1):133
pubmed: 28178935
Lancet Glob Health. 2019 Jan;7(1):e47-e57
pubmed: 30497986
Pneumonia (Nathan). 2017 Jun 25;9:9
pubmed: 28702311
Lancet. 2017 Sep 2;390(10098):946-958
pubmed: 28689664
Lancet Infect Dis. 2018 Nov;18(11):1162-1163
pubmed: 30243585
Lancet. 2019 May 25;393(10186):2146-2154
pubmed: 31000194
J Glob Health. 2015 Jun;5(1):010408
pubmed: 26445672
BMC Infect Dis. 2013 Oct 22;13:490
pubmed: 24148091
J Clin Microbiol. 2007 Aug;45(8):2460-6
pubmed: 17537936
Pediatr Infect Dis J. 2001 Mar;20(3):300-5
pubmed: 11303834
EClinicalMedicine. 2019 Oct 24;16:51-63
pubmed: 31832620
Virol J. 2012 Apr 10;9:78
pubmed: 22490115
Lancet Respir Med. 2016 Jun;4(6):463-72
pubmed: 27117547
PLoS One. 2015 Dec 22;10(12):e0145447
pubmed: 26696249
Lancet. 2011 Dec 3;378(9807):1917-30
pubmed: 22078723
J Clin Microbiol. 2011 Jul;49(7):2637-42
pubmed: 21562107
Lancet. 2019 Aug 31;394(10200):757-779
pubmed: 31257127
BMC Pediatr. 2019 Sep 5;19(1):316
pubmed: 31488088
BMC Pediatr. 2016 Aug 31;16(1):148
pubmed: 27581079
Clin Microbiol Infect. 2016 Apr;22(4):340-346
pubmed: 26585774
Lancet Infect Dis. 2021 Sep;21(9):1293-1302
pubmed: 34280357
Bull World Health Organ. 2008 May;86(5):349-55
pubmed: 18545737
J Infect Dis. 2021 Sep 1;224(12 Suppl 2):S161-S173
pubmed: 34469555
Clin Infect Dis. 2017 Jun 15;64(suppl_3):S205-S212
pubmed: 28575354
Pan Afr Med J. 2014 Oct 06;19:128
pubmed: 25745535
Microorganisms. 2020 Dec 13;8(12):
pubmed: 33322236
Lancet Infect Dis. 2017 Nov;17(11):1133-1161
pubmed: 28843578
Lancet. 2010 May 1;375(9725):1545-55
pubmed: 20399493
Diagn Microbiol Infect Dis. 2009 Aug;64(4):366-73
pubmed: 19446978
Pediatr Infect Dis J. 2007 Apr;26(4):356-8
pubmed: 17414404
Diagn Microbiol Infect Dis. 2003 Feb;45(2):85-95
pubmed: 12614979
Clin Infect Dis. 2018 Jun 1;66(12):1838-1845
pubmed: 29408951
JAMA. 2010 May 26;303(20):2051-7
pubmed: 20501927
Lancet Infect Dis. 2014 Dec;14(12):1281-92
pubmed: 25012226
PLoS One. 2018 Sep 10;13(9):e0203788
pubmed: 30199549
BMJ Glob Health. 2021 Dec;6(12):
pubmed: 34930758
N Engl J Med. 2014 Nov 13;371(20):1889-99
pubmed: 25386897