What do we know about pathological mechanism and pattern of lung injury related to SARS-CoV-2 Omicron variant?
Autopsy
Comorbidity
Diffuse alveolar damage
Immune escape process
Lung injury
Omicron
Pathological pattern
SARS-CoV-2 variants
Ventilator-induced lung injury
Journal
Diagnostic pathology
ISSN: 1746-1596
Titre abrégé: Diagn Pathol
Pays: England
ID NLM: 101251558
Informations de publication
Date de publication:
10 Feb 2023
10 Feb 2023
Historique:
received:
08
12
2022
accepted:
02
02
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Pulmonary damage in SARS-CoV-2 is characterized pathologically by diffuse alveolar damage (DAD) and thrombosis. In addition, nosocomial bacterial superinfections and ventilator-induced lung injury (VILI) are likely to occur. The SARS-CoV-2 Omicron variant have manifested itself as a more diffusive virus which mainly affects the upper airways, such as the nose and pharynx. The mechanism leading to a lung injury with a complex clinical course for the Omicron SARS-CoV-2 variant remains unclear. A key question is whether the organ damage is due to direct organ targeting of the virus or downstream effects such as an altered immune response. An immune escape process of Omicron variant is being studied, which could lead to prolonged viral shedding and increase hospitalization times in patients with comorbidities, with an increased risk of pulmonary co-infections/superinfections and organ damage. This brief commentary reports the current knowledge on the Omicron variant and provides some useful suggestions to the scientific community.
Identifiants
pubmed: 36765347
doi: 10.1186/s13000-023-01306-y
pii: 10.1186/s13000-023-01306-y
pmc: PMC9911937
doi:
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
18Informations de copyright
© 2023. The Author(s).
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