Effect of omega-3 supplementation on lipid profile in children and adolescents: a systematic review and meta-analysis of randomized clinical trials.
Children
Lipid profile
Meta-analysis
Omega-3
Systematic review
Journal
Nutrition journal
ISSN: 1475-2891
Titre abrégé: Nutr J
Pays: England
ID NLM: 101152213
Informations de publication
Date de publication:
10 02 2023
10 02 2023
Historique:
received:
24
10
2021
accepted:
10
11
2022
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Dyslipidemia is considered as a known risk factor for cardiovascular disease. Yet various trials with wide ranges of doses and durations have reported contradictory results. We undertook this meta-analysis of randomized controlled trials (RCTs) to determine whether omega-3 supplementation can affect lipid profile in children and adolescents. Cochrane Library, Embase, PubMed, and Scopus databases were searched up to March 2021. Meta-analysis was performed using random-effect method. Effect size was expressed as weighted mean difference (WMD) and 95% confidence interval (CI). Heterogeneity was assessed using the I A total of 14 RCTs with 15 data sets were included. Based on the combination of effect sizes, there was a significant reduction in TG levels (WMD: -15.71 mg/dl, 95% CI: -25.76 to -5.65, P=0.002), with remarkable heterogeneity (I Omega-3 supplementation may significantly reduce TG levels in younger children and those with hypertriglyceridemia. Also, based on the HDL-related results, clinical trials with longer duration of intervention are recommended in this population.
Identifiants
pubmed: 36765362
doi: 10.1186/s12937-022-00826-5
pii: 10.1186/s12937-022-00826-5
pmc: PMC9912483
doi:
Substances chimiques
Lipids
0
Types de publication
Meta-Analysis
Systematic Review
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9Informations de copyright
© 2023. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply.
Références
PLoS One. 2015 Oct 02;10(10):e0139565
pubmed: 26431431
Clin Pediatr (Phila). 2014 Jun;53(7):645-51
pubmed: 24647701
Dig Liver Dis. 2008 Mar;40(3):194-9
pubmed: 18054848
Ren Fail. 2010;32(9):1031-5
pubmed: 20863205
J Pediatr Endocrinol Metab. 2019 Aug 27;32(8):811-819
pubmed: 31271554
Postgrad Med. 2009 Nov;121(6):148-57
pubmed: 19940425
Drugs. 2009 May 29;69(8):1077-105
pubmed: 19496632
Hellenic J Cardiol. 2006 Jul-Aug;47(4):223-31
pubmed: 16897926
PLoS One. 2017 Jun 8;12(6):e0178868
pubmed: 28594860
Annu Rev Nutr. 2006;26:75-103
pubmed: 16848701
Rev Port Cardiol. 2015 Feb;34(2):103-9
pubmed: 25660460
Am J Cardiol. 2006 Aug 21;98(4A):27i-33i
pubmed: 16919514
Curr Probl Cardiol. 2006 Jul;31(7):445-86
pubmed: 16824902
J Nutr. 2006 Jan;136(1):94-9
pubmed: 16365065
J Am Coll Cardiol. 2012 Dec 25;60(25 Suppl):S1-49
pubmed: 23257320
J Ren Nutr. 2017 May;27(3):169-174
pubmed: 28110812
Prim Care. 2013 Mar;40(1):195-211
pubmed: 23402469
Food Res Int. 2019 May;119:469-476
pubmed: 30884679
BMJ. 1997 Sep 13;315(7109):629-34
pubmed: 9310563
J Clin Diagn Res. 2017 Mar;11(3):OC13-OC16
pubmed: 28511427
Sci Rep. 2019 Dec 11;9(1):18867
pubmed: 31827125
Indian J Endocrinol Metab. 2019 Sep-Oct;23(5):586-587
pubmed: 31803603
J Clin Endocrinol Metab. 2008 Nov;93(11 Suppl 1):S31-6
pubmed: 18987268
JAMA. 2020 Dec 8;324(22):2268-2280
pubmed: 33190147
Eur J Epidemiol. 2020 Jan;35(1):49-60
pubmed: 31720912
Cardiovasc Diabetol. 2018 Jul 7;17(1):98
pubmed: 29981570
Clin Pediatr (Phila). 2014 May;53(5):428-38
pubmed: 24707021
J Pediatr. 2014 Sep;165(3):497-503.e2
pubmed: 25008950
Med Clin North Am. 2011 Sep;95(5):893-902
pubmed: 21855698
Clin Nutr. 2008 Apr;27(2):241-7
pubmed: 18237823
J Clin Res Pediatr Endocrinol. 2015 Jun;7(2):121-7
pubmed: 26316434
Expert Opin Pharmacother. 2008 May;9(7):1237-48
pubmed: 18422480