P38 MAPK and Radiotherapy: Foes or Friends?
MAPK14
cell cycle
p38 MAPK
radiation
radiotherapy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
30 Jan 2023
30 Jan 2023
Historique:
received:
03
12
2022
revised:
16
01
2023
accepted:
24
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
12
2
2023
Statut:
epublish
Résumé
Over the last 30 years, the study of the cellular response to ionizing radiation (IR) has increased exponentially. Among the various signaling pathways affected by IR, p38 MAPK has been shown to be activated both in vitro and in vivo, with involvement in key processes triggered by IR-mediated genotoxic insult, such as the cell cycle, apoptosis or senescence. However, we do not yet have a definitive clue about the role of p38 MAPK in terms of radioresistance/sensitivity and its potential use to improve current radiotherapy. In this review, we summarize the current knowledge on this family of MAPKs in response to IR as well as in different aspects related to radiotherapy, such as their role in the control of REDOX, fibrosis, and in the radiosensitizing effect of several compounds.
Identifiants
pubmed: 36765819
pii: cancers15030861
doi: 10.3390/cancers15030861
pmc: PMC9913882
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
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