Immune-Activated B Cells Are Dominant in Prostate Cancer.
B cells
T cells
prostatic neoplasms
sentinel lymph node biopsy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
01 Feb 2023
01 Feb 2023
Historique:
received:
10
12
2022
revised:
22
01
2023
accepted:
29
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
12
2
2023
Statut:
epublish
Résumé
B cells are multifaceted immune cells responding robustly during immune surveillance against tumor antigens by presentation to T cells and switched immunoglobulin production. However, B cells are unstudied in prostate cancer (PCa). We used flow cytometry to analyze B-cell subpopulations in peripheral blood and lymph nodes from intermediate-high risk PCa patients. B-cell subpopulations were related to clinicopathological factors. B-cell-receptor single-cell sequencing and VDJ analysis identified clonal B-cell expansion in blood and lymph nodes. Pathological staging was pT2 in 16%, pT3a in 48%, and pT3b in 36%. Lymph node metastases occurred in 5/25 patients (20%). Compared to healthy donors, the peripheral blood CD19
Identifiants
pubmed: 36765877
pii: cancers15030920
doi: 10.3390/cancers15030920
pmc: PMC9913271
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Uppsala Multidisciplinary Center for Advanced Computational Science
ID : SNIC 2019/8-143 and uppstore2019-30-9
Organisme : Vetenskapsrådet
ID : 2022-5-18
Organisme : Sveriges Regering
ID : RV-970150
Références
J Transl Med. 2014 Jan 30;12:30
pubmed: 24475900
Nat Commun. 2021 Feb 10;12(1):935
pubmed: 33568675
NPJ Breast Cancer. 2018 Aug 23;4:28
pubmed: 30155518
Proc Natl Acad Sci U S A. 2014 Oct 14;111(41):14776-81
pubmed: 25267627
J Immunol. 2010 Nov 1;185(9):4977-82
pubmed: 20962266
J Immunol. 2008 Feb 1;180(3):1362-72
pubmed: 18209030
Eur J Cancer Care (Engl). 2008 Jul;17(4):404-11
pubmed: 18485013
Eur Urol Focus. 2018 Jan;4(1):75-79
pubmed: 28753790
Clin Cancer Res. 2011 Jul 1;17(13):4550-7
pubmed: 21498393
Cell. 2015 May 21;161(5):1215-1228
pubmed: 26000489
Adv Exp Med Biol. 2006;587:341-74
pubmed: 17163176
Clin Cancer Res. 2015 Aug 15;21(16):3619-30
pubmed: 25649018
Nature. 2013 Jul 11;499(7457):214-218
pubmed: 23770567
Nat Rev Immunol. 2015 Jul;15(7):441-51
pubmed: 26065586
Medicina (B Aires). 2014;74(3):185-8
pubmed: 24918664
Immunity. 2001 Feb;14(2):111-21
pubmed: 11239444
Scand J Immunol. 2020 Feb;91(2):e12830
pubmed: 31823416
J Exp Med. 2021 Jan 4;218(1):
pubmed: 33601413
Mol Biol Rep. 2018 Dec;45(6):2935-2940
pubmed: 30311129
J Oncol. 2019 Sep 24;2019:2592419
pubmed: 31662750
Cancers (Basel). 2021 Jan 24;13(3):
pubmed: 33498854
Sci Rep. 2015 Jul 20;5:12255
pubmed: 26193241
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Nature. 2015 May 7;521(7550):94-8
pubmed: 25924065
Afr Health Sci. 2020 Sep;20(3):1264-1272
pubmed: 33402974
J Natl Cancer Inst. 2019 Mar 1;111(3):301-310
pubmed: 30321406
Cytometry B Clin Cytom. 2008 Sep;74(5):261-71
pubmed: 18561200
Cancer Immunol Immunother. 2009 Oct;58(10):1535-44
pubmed: 19562338
J Immunol. 2009 Feb 15;182(4):1868-76
pubmed: 19201839
Proc Natl Acad Sci U S A. 2004 Oct 5;101 Suppl 2:14639-45
pubmed: 15381769
Cell. 2015 Nov 5;163(4):1011-25
pubmed: 26544944
Nat Rev Cancer. 2012 Mar 22;12(4):278-87
pubmed: 22437872
Nature. 2010 Mar 11;464(7286):302-5
pubmed: 20220849
Int J Mol Sci. 2014 Nov 05;15(11):20209-39
pubmed: 25380524
Oncogene. 2010 Feb 25;29(8):1093-102
pubmed: 19946335
Cancer Res. 2011 Sep 1;71(17):5601-5
pubmed: 21846822
J Exp Med. 1996 Mar 1;183(3):1161-72
pubmed: 8642258
J Immunol. 2009 Sep 1;183(5):3195-203
pubmed: 19667089
PLoS Med. 2019 Mar 12;16(3):e1002758
pubmed: 30860997
Eur Urol. 2010 Jul;58(1):105-11
pubmed: 19766386
J Immunol. 2005 Aug 1;175(3):1424-32
pubmed: 16034078
N Engl J Med. 2016 Aug 4;375(5):443-53
pubmed: 27433846
J Immunol. 2013 Jun 1;190(11):5847-55
pubmed: 23630345
Science. 2015 Apr 3;348(6230):56-61
pubmed: 25838373
Lancet Oncol. 2006 Dec;7(12):1006-16
pubmed: 17138222
PLoS Med. 2016 Aug 02;13(8):e1002063
pubmed: 27483464