Antifibrotic Soluble Thy-1 Correlates with Renal Dysfunction in Chronic Kidney Disease.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
18 Jan 2023
Historique:
received: 01 12 2022
revised: 12 01 2023
accepted: 12 01 2023
entrez: 11 2 2023
pubmed: 12 2 2023
medline: 15 2 2023
Statut: epublish

Résumé

Kidney fibrosis is a major culprit in the development and progression of chronic kidney disease (CKD), ultimately leading to the irreversible loss of organ function. Thymocyte differentiation antigen-1 (Thy-1) controls many core functions of fibroblasts relevant to fibrogenesis but is also found in a soluble form (sThy-1) in serum and urine. We investigated the association of sThy-1 with clinical parameters in patients with CKD receiving hemodialysis treatment compared to individuals with a preserved renal function. Furthermore, Thy-1 tissue expression was detected in a mouse model of diabetic CKD (eNOS

Identifiants

pubmed: 36768219
pii: ijms24031896
doi: 10.3390/ijms24031896
pmc: PMC9916214
pii:
doi:

Substances chimiques

Creatinine AYI8EX34EU
Thy-1 Antigens 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : SA 863/9-1

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Auteurs

Anja Saalbach (A)

Department of Dermatology, Venereology and Allergology, University of Leipzig Medical Center, 04103 Leipzig, Germany.

Ulf Anderegg (U)

Department of Dermatology, Venereology and Allergology, University of Leipzig Medical Center, 04103 Leipzig, Germany.

Ralph Wendt (R)

Hospital St. Georg, Division of Nephrology and Kuratorium for Dialysis and Transplantation, 04129 Leipzig, Germany.

Joachim Beige (J)

Hospital St. Georg, Division of Nephrology and Kuratorium for Dialysis and Transplantation, 04129 Leipzig, Germany.
Department for Internal Medicine, Medical Clinic 2, Martin-Luther-University Halle/Wittenberg, 06108 Halle, Germany.

Anette Bachmann (A)

Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.

Nora Klöting (N)

Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.

Matthias Blüher (M)

Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.
Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.

Ming-Zhi Zhang (MZ)

Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.
Department of Medicine, Nashville Veterans Affairs Hospital, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.

Raymond C Harris (RC)

Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.
Department of Medicine, Nashville Veterans Affairs Hospital, Vanderbilt University School of Medicine, Nashville, TN 37212, USA.

Michael Stumvoll (M)

Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.

Anke Tönjes (A)

Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.

Thomas Ebert (T)

Medical Department III-Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, 04103 Leipzig, Germany.

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Classifications MeSH