Cabotegravir Exposure of Zebrafish (
INSTI
cabotegravir
developmental toxicity
dolutegravir
integrase inhibitor
pregnancy
zebrafish embryo
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
19 Jan 2023
19 Jan 2023
Historique:
received:
21
12
2022
revised:
13
01
2023
accepted:
17
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
As most new medications, Cabotegravir (CAB) was recently approved as an antiretroviral treatment of HIV infection without in-depth safety information on in utero exposure. Although no developmental toxicity in rats and rabbits was reported, recent studies demonstrated that CAB decreases pluripotency of human embryonic stem cells. CAB exposure effects during development were assessed in zebrafish embryos by the Fish Embryo Toxicity test after exposure at subtherapeutic concentrations up to 25× the human C
Identifiants
pubmed: 36768311
pii: ijms24031994
doi: 10.3390/ijms24031994
pmc: PMC9916638
pii:
doi:
Substances chimiques
cabotegravir
HMH0132Z1Q
Water Pollutants, Chemical
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : University of Brescia
ID : ex 60%
Références
Pharmaceuticals (Basel). 2022 Dec 09;15(12):
pubmed: 36558984
Dev Dyn. 1998 Sep;213(1):92-104
pubmed: 9733104
EBioMedicine. 2021 Jan;63:103167
pubmed: 33341441
N Engl J Med. 2019 Aug 29;381(9):827-840
pubmed: 31329379
HIV AIDS (Auckl). 2016 Oct 14;8:157-164
pubmed: 27799824
AIDS. 2020 Jul 15;34(9):1377-1387
pubmed: 32310900
IUBMB Life. 2007 Apr-May;59(4-5):299-307
pubmed: 17505969
HIV Med. 2022 Nov 21;:
pubmed: 36411596
EBioMedicine. 2022 Jan;75:103771
pubmed: 34954655
AIDS. 2020 Nov 15;34(14):2145-2149
pubmed: 32796211
Xenobiotica. 2016;46(5):445-56
pubmed: 26340566
J Infect Dis. 2022 Nov 28;226(11):1992-2001
pubmed: 36124861
Toxicol Sci. 2021 Nov 24;184(2):191-203
pubmed: 34515794
AIDS. 2019 Nov 1;33(13):1967-1976
pubmed: 31259764
Proc Natl Acad Sci U S A. 2006 Mar 28;103(13):5143-8
pubmed: 16549779
J Acquir Immune Defic Syndr. 2019 Aug 1;81(4):371-378
pubmed: 30939532
Biomedicines. 2019 Mar 26;7(1):
pubmed: 30917585
Pharmaceutics. 2022 Aug 24;14(9):
pubmed: 36145509
Congenit Anom (Kyoto). 2016 Jan;56(1):18-27
pubmed: 26537640
Mol Neurobiol. 2021 Nov;58(11):5703-5721
pubmed: 34390469
Dev Dyn. 1995 Jul;203(3):253-310
pubmed: 8589427
N Engl J Med. 2018 Sep 6;379(10):979-981
pubmed: 30037297
BMC Pharmacol Toxicol. 2017 Nov 15;18(1):72
pubmed: 29141695
Birth Defects Res. 2022 Nov 14;:
pubmed: 36373861
J Neurosci Res. 2007 Oct;85(13):2813-23
pubmed: 17387691
Lancet HIV. 2021 Jan;8(1):e33-e41
pubmed: 33387477
Neural Regen Res. 2016 Mar;11(3):357-62
pubmed: 27127457
Dev Biol. 2002 Nov 1;251(1):45-58
pubmed: 12413897
Drug Metab Dispos. 2013 Feb;41(2):353-61
pubmed: 23132334
Biochim Biophys Acta. 2014 Apr;1842(4):665-75
pubmed: 24463171
Nature. 2013 Apr 25;496(7446):498-503
pubmed: 23594743