Neural Tube Defects and Folate Deficiency: Is DNA Repair Defective?
DNA damage
DNA repair
folate
neural tube defects
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Jan 2023
22 Jan 2023
Historique:
received:
05
12
2022
revised:
13
01
2023
accepted:
19
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Neural tube defects (NTDs) are complex congenital malformations resulting from failure of neural tube closure during embryogenesis, which is affected by the interaction of genetic and environmental factors. It is well known that folate deficiency increases the incidence of NTDs; however, the underlying mechanism remains unclear. Folate deficiency not only causes DNA hypomethylation, but also blocks the synthesis of 2'-deoxythymidine-5'-monophosphate (dTMP) and increases uracil misincorporation, resulting in genomic instabilities such as base mismatch, DNA breakage, and even chromosome aberration. DNA repair pathways are essential for ensuring normal DNA synthesis, genomic stability and integrity during embryonic neural development. Genomic instability or lack of DNA repair has been implicated in risk of development of NTDs. Here, we reviewed the relationship between folate deficiency, DNA repair pathways and NTDs so as to reveal the role and significance of DNA repair system in the pathogenesis of NTDs and better understand the pathogenesis of NTDs.
Identifiants
pubmed: 36768542
pii: ijms24032220
doi: 10.3390/ijms24032220
pmc: PMC9916799
pii:
doi:
Substances chimiques
Folic Acid
935E97BOY8
DNA
9007-49-2
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : the Beijing Natural Science Foundation
ID : 7222016
Organisme : Research Foundation of Capital Institute of Pediatrics
ID : CXYJ-2021-03
Références
Pediatr Res. 2022 Oct;92(4):987-994
pubmed: 34934172
Teratology. 1993 Jan;47(1):73-80
pubmed: 8475460
EMBO J. 2002 Apr 15;21(8):2038-44
pubmed: 11953323
Annu Rev Biochem. 2010;79:181-211
pubmed: 20192759
J Cell Mol Med. 2022 Feb;26(3):776-788
pubmed: 34953021
Nucleic Acids Res. 2016 Jan 29;44(2):538-44
pubmed: 26615196
Neuron. 2014 Jul 16;83(2):266-282
pubmed: 25033177
EMBO J. 1999 Mar 1;18(5):1172-81
pubmed: 10064584
Mol Cell. 2004 Jul 23;15(2):209-20
pubmed: 15260972
Neurobiol Dis. 2013 Jun;54:404-13
pubmed: 23376398
Pediatrics. 2006 Sep;118(3):916-23
pubmed: 16950981
Genes (Basel). 2021 Dec 09;12(12):
pubmed: 34946909
Biochem Pharmacol. 2005 Nov 15;70(10):1458-68
pubmed: 16191427
Antioxid Redox Signal. 2011 Jun 15;14(12):2491-507
pubmed: 20649466
Dev Biol. 1999 Apr 15;208(2):513-29
pubmed: 10191063
Proc Natl Acad Sci U S A. 2021 Jul 13;118(28):
pubmed: 34244426
Med Sci Monit. 2018 Jul 19;24:5015-5026
pubmed: 30022792
Public Health Nutr. 2009 May;12(5):680-6
pubmed: 18547453
Am J Med Genet. 1993 Oct 1;47(5):723-43
pubmed: 8267004
Am J Clin Nutr. 2010 May;91(5):1359-67
pubmed: 20164316
EMBO J. 2007 Jun 6;26(11):2732-42
pubmed: 17476307
Free Radic Biol Med. 2011 Jan 15;50(2):270-80
pubmed: 21070850
J Biol Chem. 1997 Sep 19;272(38):23970-5
pubmed: 9295348
Am J Hum Genet. 2008 Mar;82(3):539-66
pubmed: 18319069
Handb Clin Neurol. 2013;111:129-41
pubmed: 23622158
Cell Mol Life Sci. 2018 Nov;75(21):3963-3976
pubmed: 30116853
Epigenetics Chromatin. 2019 Nov 13;12(1):69
pubmed: 31722724
Pan Afr Med J. 2021 Dec 21;40:248
pubmed: 35233268
Mutat Res. 2012 May 1;733(1-2):21-33
pubmed: 22093367
Exp Cell Res. 2021 Aug 15;405(2):112679
pubmed: 34102225
Hum Mutat. 2018 Apr;39(4):550-562
pubmed: 29297599
Annu Rev Genet. 2015;49:291-313
pubmed: 26436461
EMBO J. 2001 Mar 15;20(6):1477-82
pubmed: 11250913
J Alzheimers Dis. 2019;70(4):1133-1142
pubmed: 31306134
Int J Environ Res Public Health. 2013 Sep 17;10(9):4352-89
pubmed: 24048206
Vitam Horm. 2008;79:375-92
pubmed: 18804702
Saudi Med J. 2014 Dec;35 Suppl 1:S15-28
pubmed: 25551106
Birth Defects Res A Clin Mol Teratol. 2007 Mar;79(3):187-210
pubmed: 17177317
Science. 1995 Aug 4;269(5224):699-702
pubmed: 7624801
Reprod Toxicol. 2011 Nov;32(3):255-60
pubmed: 21708246
Birth Defects Res. 2021 Jul 15;113(12):968-980
pubmed: 33754462
Proc Natl Acad Sci U S A. 1980 Apr;77(4):1956-60
pubmed: 6929529
FASEB J. 2019 Apr;33(4):4688-4702
pubmed: 30592646
Annu Rev Neurosci. 2014;37:221-42
pubmed: 25032496
Am J Med Genet A. 2005 Jun 15;135(3):268-73
pubmed: 15887293
Nat Genet. 1999 Nov;23(3):266-8
pubmed: 10545939
Mutat Res. 2005 Sep 4;577(1-2):275-83
pubmed: 15922366
Reprod Toxicol. 2018 Mar;76:17-25
pubmed: 29258758
Pharmacol Ther. 2018 Sep;189:45-62
pubmed: 29669262
Eur Urol. 2019 Oct;76(4):469-478
pubmed: 31345636
Pediatrics. 1995 Apr;95(4):506-10
pubmed: 7700749
N Engl J Med. 1992 Dec 24;327(26):1832-5
pubmed: 1307234
Mol Cell Biol. 2011 Nov;31(22):4623-32
pubmed: 21930793
Cell. 2013 Apr 25;153(3):590-600
pubmed: 23622243
Br J Cancer. 2006 Jun 19;94(12):1942-7
pubmed: 16736000
World J Gastroenterol. 2007 Mar 28;13(12):1767-9
pubmed: 17465465
Int J Dev Neurosci. 2007 Dec;25(8):531-7
pubmed: 18022788
Nat Rev Mol Cell Biol. 2017 Aug;18(8):495-506
pubmed: 28512351
J Mol Neurosci. 2012 May;47(1):42-51
pubmed: 22101741
Am J Gastroenterol. 1998 Nov;93(11):2060-4
pubmed: 9820373
Neurotoxicology. 2010 Mar;31(2):180-7
pubmed: 20060418
Acta Biochim Biophys Sin (Shanghai). 2019 Sep 6;51(9):879-889
pubmed: 31294447
EMBO J. 2009 Nov 4;28(21):3413-27
pubmed: 19779458
Biochimie. 2016 Jul;126:52-6
pubmed: 26586110
J Nutr. 2020 Jul 1;150(7):1705-1712
pubmed: 32271909
Nat Genet. 1996 Feb;12(2):191-4
pubmed: 8563759
J Pathol. 2010 Jan;220(2):217-30
pubmed: 19918803
PLoS One. 2013;8(1):e54492
pubmed: 23349908
J Neurochem. 2006 Jun;97(6):1571-84
pubmed: 16805769
Neurotoxicol Teratol. 2005 May-Jun;27(3):515-24
pubmed: 15939212
Essays Biochem. 2020 Oct 26;64(5):831-843
pubmed: 32648895
Eur J Hum Genet. 2012 May;20(5):516-20
pubmed: 22234160
J Biol Chem. 2016 Aug 12;291(33):16990-7000
pubmed: 27369079
Dev Biol. 2004 Oct 1;274(1):15-30
pubmed: 15355785
N Engl J Med. 2009 Oct 8;361(15):1475-85
pubmed: 19812404
Birth Defects Res. 2019 Nov 15;111(19):1455-1467
pubmed: 30421543
Georgian Med News. 2020 Jan;(298):61-66
pubmed: 32141851
Prenat Diagn. 2009 Apr;29(4):303-11
pubmed: 19206138
Nucleic Acids Res. 2020 Jan 10;48(1):264-277
pubmed: 31647103
Int J Dev Biol. 2011;55(1):65-72
pubmed: 21425081
J Appl Toxicol. 2014 Aug;34(8):862-9
pubmed: 23836430
Clin Chem Lab Med. 2007;45(12):1760-3
pubmed: 18067453
Adv Nutr. 2012 Jan;3(1):21-38
pubmed: 22332098
Nat Rev Dis Primers. 2015 Apr 30;1:15007
pubmed: 27189655
Proc Natl Acad Sci U S A. 1996 Aug 20;93(17):8919-23
pubmed: 8799128
Gastroenterology. 2010 Jun;138(6):2073-2087.e3
pubmed: 20420947
Front Cell Neurosci. 2020 Jun 30;14:201
pubmed: 32714152
Nucleic Acids Res. 2017 Mar 17;45(5):2472-2489
pubmed: 27924000
DNA Repair (Amst). 2019 May;77:36-44
pubmed: 30875637
Cold Spring Harb Perspect Biol. 2013 Apr 01;5(4):a012583
pubmed: 23545420
Cell. 2000 Sep 15;102(6):721-9
pubmed: 11030616
Cancer Genet Cytogenet. 2010 Mar;197(2):142-51
pubmed: 20193847
N Engl J Med. 1999 Nov 11;341(20):1485-90
pubmed: 10559448
Mol Cell Biochem. 2015 Jan;398(1-2):223-31
pubmed: 25245820
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3290-5
pubmed: 9096386
Am J Clin Nutr. 2011 Apr;93(4):789-98
pubmed: 21346092
Dev Biol. 2009 Jan 1;325(1):225-37
pubmed: 19000668
Clin Oncol (R Coll Radiol). 2014 May;26(5):243-9
pubmed: 24630811
J Appl Toxicol. 2013 Sep;33(9):915-23
pubmed: 22806879
J Cell Mol Med. 2010 Dec;14(12):2697-701
pubmed: 21029369
J Biol Chem. 1996 Apr 19;271(16):9573-8
pubmed: 8621631
Genes (Basel). 2020 May 01;11(5):
pubmed: 32369918
DNA Repair (Amst). 2018 Nov;71:158-163
pubmed: 30195640
Nutrients. 2013 Nov 21;5(11):4760-75
pubmed: 24284617
Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9831-5
pubmed: 19482943
J Cell Physiol. 2001 May;187(2):137-44
pubmed: 11267993
Curr Mol Pharmacol. 2012 Jan;5(1):3-13
pubmed: 22122461
Wiley Interdiscip Rev Dev Biol. 2013 Mar-Apr;2(2):213-27
pubmed: 24009034
Obstet Gynecol. 2017 Dec;130(6):e279-e290
pubmed: 29189693
J Biol Chem. 2004 Aug 27;279(35):36504-13
pubmed: 15218023
Front Genet. 2021 May 10;12:659612
pubmed: 34040637
FASEB J. 1998 Nov;12(14):1491-7
pubmed: 9806758
Semin Cancer Biol. 2010 Oct;20(5):320-8
pubmed: 20955798
Curr Nutr Rep. 2018 Sep;7(3):70-84
pubmed: 30099693
Trends Biochem Sci. 2017 Sep;42(9):690-701
pubmed: 28739276
Epigenetics. 2022 Jan-Feb;17(2):133-146
pubmed: 33491544
Cancer Genet Cytogenet. 2003 Sep;145(2):103-7
pubmed: 12935920
Annu Rev Biochem. 2004;73:39-85
pubmed: 15189136
JAMA. 2017 Jan 10;317(2):183-189
pubmed: 28097362
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):2956-61
pubmed: 20133625
Curr Opin Genet Dev. 2005 Jun;15(3):234-40
pubmed: 15917197
Reprod Sci. 2021 Sep;28(9):2592-2601
pubmed: 33761125
Epigenomics. 2020 Jan;12(1):5-18
pubmed: 31769301
Mol Pharmacol. 1982 Jan;21(1):211-6
pubmed: 6215571
J Mol Med (Berl). 2003 Nov;81(11):700-7
pubmed: 13679996
DNA Repair (Amst). 2008 Jun 1;7(6):932-40
pubmed: 18472309