Myeloma Microenvironmental TIMP1 Induces the Invasive Phenotype in Fibroblasts to Modulate Disease Progression.
fibroblast
multiple myeloma
tissue inhibitor of metalloproteinase
tumour microenvironment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
22 Jan 2023
22 Jan 2023
Historique:
received:
16
12
2022
revised:
13
01
2023
accepted:
18
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Tissue inhibitors of metalloproteinases (TIMPs) are endogenous matrix metalloproteinase inhibitors. TIMP1 is produced by cancer cells and has pleiotropic activities. However, its role and source in multiple myeloma (MM) are unclear. Here, we evaluated TIMP1 protein and mRNA levels in bone marrow (BM) plasma cells and assessed the effects of TIMP1 expression on fibroblast invasive capacity using three-dimensional spheroid cell invasion assays.
Identifiants
pubmed: 36768545
pii: ijms24032216
doi: 10.3390/ijms24032216
pmc: PMC9917104
pii:
doi:
Substances chimiques
Tissue Inhibitor of Metalloproteinase-1
0
RNA, Messenger
0
TIMP1 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Celgene corporation
ID : Non-clinical Research Grant
Références
Crit Rev Oncol Hematol. 2003 Mar;45(3):227-44
pubmed: 12633837
Nat Cell Biol. 2007 Dec;9(12):1392-400
pubmed: 18037882
Biochem Biophys Res Commun. 2021 Jan 1;534:843-848
pubmed: 33183761
Leuk Res. 2010 Mar;34(3):399-402
pubmed: 19781774
Clin Cancer Res. 2006 Dec 1;12(23):7054-8
pubmed: 17114213
Br J Haematol. 2001 Dec;115(3):595-604
pubmed: 11736941
Int J Mol Sci. 2021 Aug 27;22(17):
pubmed: 34502227
J Exp Clin Cancer Res. 2016 Sep 20;35(1):148
pubmed: 27644693
J Pathol. 2006 Jan;208(1):108-18
pubmed: 16278822
World J Surg Oncol. 2013 Apr 02;11:81
pubmed: 23548070
Biomed Pharmacother. 2011 Jun;65(3):163-7
pubmed: 21684102
Dig Liver Dis. 2020 Oct;52(10):1170-1177
pubmed: 32522433
Front Immunol. 2020 Aug 04;11:1731
pubmed: 32849616
J Pathol. 2002 Jul;197(3):307-13
pubmed: 12115876
Blood. 1998 Aug 15;92(4):1342-9
pubmed: 9694723
Biomed Res Int. 2014;2014:636514
pubmed: 25093175
Front Biosci (Landmark Ed). 2012 Jun 01;17(7):2667-74
pubmed: 22652804
Blood. 2022 Jun 30;139(26):3708-3721
pubmed: 35090171
Matrix Biol. 2018 Aug;68-69:452-462
pubmed: 29221811
Nat Commun. 2022 Feb 10;13(1):807
pubmed: 35145077
Breast Cancer Res Treat. 1999 Apr;54(3):235-44
pubmed: 10445422
Adv Drug Deliv Rev. 2016 Apr 1;99(Pt B):180-185
pubmed: 26621196
Tumour Biol. 2013 Dec;34(6):3839-51
pubmed: 23881388
Biosci Rep. 2016 Jul 15;36(4):
pubmed: 27247426
Blood. 2005 Feb 15;105(4):1660-8
pubmed: 15479729
Blood. 2008 Mar 15;111(6):2962-72
pubmed: 18332230
Pathology. 2007 Oct;39(5):512-5
pubmed: 17886102
Br J Haematol. 2015 Jun;169(6):843-50
pubmed: 26032514
J Mol Med (Berl). 2016 Jan;94(1):21-35
pubmed: 26423531
N Engl J Med. 2018 Jan 18;378(3):241-249
pubmed: 29342381
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Biochem Biophys Res Commun. 2011 Jun 3;409(2):344-9
pubmed: 21586274
Gastric Cancer. 2009;12(1):31-6
pubmed: 19390929
Nat Rev Immunol. 2013 Sep;13(9):649-65
pubmed: 23969736
Toxicol Appl Pharmacol. 2017 Nov 15;335:64-71
pubmed: 28974454
Cancer. 2007 May 15;109(10):1933-9
pubmed: 17407159
Mol Cancer. 2017 Feb 28;16(1):49
pubmed: 28241871
Bone Marrow Transplant. 2013 Mar;48(3):452-8
pubmed: 23208313
Nat Rev Cancer. 2020 Mar;20(3):174-186
pubmed: 31980749
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Best Pract Res Clin Haematol. 2005;18(4):509-24
pubmed: 16026734
Front Cell Dev Biol. 2021 Jul 06;9:698047
pubmed: 34295898
Nanotoxicology. 2017 Feb;11(1):41-51
pubmed: 27852133
Hematology. 2016 Jan;21(1):26-33
pubmed: 26268417
Sci Signal. 2008 Jul 08;1(27):re6
pubmed: 18612141
Int J Hematol. 2013 Mar;97(3):313-23
pubmed: 23456262
Mol Cell Proteomics. 2008 Feb;7(2):424-30
pubmed: 17998244
Cell Tissue Res. 2016 Sep;365(3):607-19
pubmed: 27474009
Int J Cancer. 2008 May 1;122(9):2050-6
pubmed: 18172859
N Engl J Med. 2011 Mar 17;364(11):1046-60
pubmed: 21410373
Leuk Res. 2008 Nov;32(11):1763-9
pubmed: 18472160