3R principles
LD50
Tenebrio molitor
animal models
antivirals
metabolism
toxicity assessment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
24 Jan 2023
24 Jan 2023
Historique:
received:
28
12
2022
revised:
20
01
2023
accepted:
22
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
The progression of drugs into clinical phases requires proper toxicity assessment in animals and the correct identification of possible metabolites. Accordingly, different animal models are used to preliminarily evaluate toxicity and biotransformations. Rodents are the most common models used to preliminarily evaluate the safety of drugs; however, their use is subject to ethical consideration and elevated costs, and strictly regulated by national legislations. Herein, we developed a novel, cheap and convenient toxicity model using
Identifiants
pubmed: 36768618
pii: ijms24032296
doi: 10.3390/ijms24032296
pmc: PMC9917132
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Tuscany Region
ID : Tuscavir.net Project
Références
Clin Pharmacokinet. 1990 May;18(5):381-408
pubmed: 2185908
Expert Opin Drug Metab Toxicol. 2006 Dec;2(6):875-94
pubmed: 17125407
Sci Rep. 2022 Nov 11;12(1):19309
pubmed: 36369211
Food Chem. 2022 Nov 1;393:133409
pubmed: 35751205
Food Chem. 2023 Mar 1;403:134298
pubmed: 36182851
Virulence. 2016 Apr 2;7(3):214-29
pubmed: 26730990
J Pharmacol Exp Ther. 2007 Sep;322(3):1208-20
pubmed: 17556636
Virulence. 2016 Oct 2;7(7):840-5
pubmed: 27362761
Mol Pharmacol. 1976 Sep;12(5):759-68
pubmed: 995125
J Appl Toxicol. 2021 Jan;41(1):33-51
pubmed: 32656821
Toxicology. 1980;17(1):73-81
pubmed: 7434370
Bioorg Med Chem Lett. 2020 Dec 1;30(23):127545
pubmed: 32931913
Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082
pubmed: 29126136
Int J Antimicrob Agents. 2021 Jul;58(1):106362
pubmed: 34010710
Adv Appl Microbiol. 2012;78:25-53
pubmed: 22305092
Int J Toxicol. 2016 Mar-Apr;35(2):95-178
pubmed: 26755718
Pathog Dis. 2021 Feb 19;79(2):
pubmed: 33476383
Virulence. 2018 Jan 1;9(1):22-24
pubmed: 28981394
J Econ Entomol. 2016 Aug 11;109(5):2090-2095
pubmed: 27515595
J Appl Toxicol. 2017 Jan;37(1):50-59
pubmed: 27443595
Infect Drug Resist. 2021 Jun 03;14:2059-2072
pubmed: 34113132
Microorganisms. 2020 Mar 11;8(3):
pubmed: 32168839
Biol Pharm Bull. 2013;36(9):1482-7
pubmed: 23995660
Antimicrob Agents Chemother. 2021 Mar 1;:
pubmed: 33649113
Cancers (Basel). 2021 Nov 07;13(21):
pubmed: 34771731
Eur J Clin Pharmacol. 1993;45(6):563-9
pubmed: 8157044
Arch Insect Biochem Physiol. 2022 Nov;111(3):e21954
pubmed: 36065122
Fundam Appl Toxicol. 1983 Nov-Dec;3(6):573-8
pubmed: 6662299
BMC Res Notes. 2017 Aug 29;10(1):428
pubmed: 28851426
J Insect Physiol. 2018 May - Jun;107:89-96
pubmed: 29477466
BMC Res Notes. 2019 Jan 7;12(1):7
pubmed: 30616595