The Effect of Renal Denervation on T Cells in Patients with Resistant Hypertension.
T cells
immune response
inflammation
lymphocytes
pro-inflammatory cytokines
renal denervation
resistant hypertension
sympathetic activity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Jan 2023
27 Jan 2023
Historique:
received:
24
12
2022
revised:
21
01
2023
accepted:
23
01
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
(1) Background: Sympathetic overactivity is a major contributor to resistant hypertension (RH). According to animal studies, sympathetic overactivity increases immune responses, thereby aggravating hypertension and cardiovascular outcomes. Renal denervation (RDN) reduces sympathetic nerve activity in RH. Here, we investigate the effect of RDN on T-cell signatures in RH. (2) Methods: Systemic inflammation and T-cell subsets were analyzed in 17 healthy individuals and 30 patients with RH at baseline and 6 months after RDN. (3) Results: The patients with RH demonstrated higher levels of pro-inflammatory cytokines and higher frequencies of CD4+ effector memory (T
Identifiants
pubmed: 36768814
pii: ijms24032493
doi: 10.3390/ijms24032493
pmc: PMC9917284
pii:
doi:
Substances chimiques
Cytokines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Erben Felder Foundation
Organisme : Heinrich-Heine University Düsseldorf
Organisme : German Research Society
ID : DFG STE2042/2-1
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