Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53
L-Asparaginase
adhesion
autophagy
colorectal cancer
extracellular matrix
p53
radiotherapy
ɣH2AX
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
03 Feb 2023
03 Feb 2023
Historique:
received:
26
10
2022
revised:
21
01
2023
accepted:
01
02
2023
entrez:
11
2
2023
pubmed:
12
2
2023
medline:
15
2
2023
Statut:
epublish
Résumé
Colorectal cancer (CRC) is the most prominent form of colon cancer for both incidence (38.7 per 100,000 people) and mortality (13.9 per 100,000 people). CRC's poor response to standard therapies is linked to its high heterogeneity and complex genetic background. Dysregulation or depletion of the tumor suppressor p53 is involved in CRC transformation and its capability to escape therapy, with p53
Identifiants
pubmed: 36769302
pii: ijms24032983
doi: 10.3390/ijms24032983
pmc: PMC9917910
pii:
doi:
Substances chimiques
Asparagine
7006-34-0
Glutamine
0RH81L854J
Tumor Suppressor Protein p53
0
Asparaginase
EC 3.5.1.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Education, Universities and Research
ID : NA
Organisme : ASSOCIAZIONE GIAN FRANCO LUPO - UN SORRISO ALLA VITA ONLUS
ID : NA
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